DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG42741 and KLF3

DIOPT Version :9

Sequence 1:NP_611747.2 Gene:CG42741 / 37654 FlyBaseID:FBgn0261705 Length:362 Species:Drosophila melanogaster
Sequence 2:NP_057615.3 Gene:KLF3 / 51274 HGNCID:16516 Length:345 Species:Homo sapiens


Alignment Length:378 Identity:127/378 - (33%)
Similarity:170/378 - (44%) Gaps:98/378 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly     9 SDPLSAKEAEGPP-----VQVEPVDLSLRSPRASTSHGSSSSSYKFSSANKAVGYSNGKPGGSSG 68
            |.||..|..:.|.     :|:|||||::....:..|.|:|.||.||.|:::     ...||.|..
Human    39 STPLPEKFFQTPEGLSHGIQMEPVDLTVNKRSSPPSAGNSPSSLKFPSSHR-----RASPGLSMP 98

  Fly    69 SSSS--SGFGAGSAGSSSLG-------AFAAQQQQQLYASSGVSKLPFSPFFAASPFFFTYRRIS 124
            |||.  ..:...|.|....|       ..||...:....|.|:  ||........|..|.|    
Human    99 SSSPPIKKYSPPSPGVQPFGVPLSMPPVMAAALSRHGIRSPGI--LPVIQPVVVQPVPFMY---- 157

  Fly   125 GSGSGNGTG------SVSVKQEDNNNSCSYNNGSSSGGAGSAANSMQDYESKFSLLSLFKNPYKF 183
                   |.      .||:.:|..|:|.|..           ...::.||...|...:...|   
Human   158 -------TSHLQQPLMVSLSEEMENSSSSMQ-----------VPVIESYEKPISQKKIKIEP--- 201

  Fly   184 AGGDGQAS----RKTSPTGGSSKPLASNSSPSWKSYAGSGSPHAALNPAFGGMGRGATRKDNSSF 244
             |.:.|.:    .:.||      ||.::.||. ::......|...:.|     |:.....::.  
Human   202 -GIEPQRTDYYPEEMSP------PLMNSVSPP-QALLQENHPSVIVQP-----GKRPLPVESP-- 251

  Fly   245 SGINFGGGGSAFGFTTSSDSMANGGYNDLSKNRKVHKCDTEGCDKVYTKSSHLKAHKRTHTGEKP 309
                                       |..:.|::|:||.:||:||||||||||||:||||||||
Human   252 ---------------------------DTQRKRRIHRCDYDGCNKVYTKSSHLKAHRRTHTGEKP 289

  Fly   310 YVCTWEGCIWRFARSDELTRHYRKHTGVKPFRCQLCTRSFSRSDHLSLHMRRH 362
            |.||||||.|:||||||||||:|||||:|||:|..|.|||||||||:||.:||
Human   290 YKCTWEGCTWKFARSDELTRHFRKHTGIKPFQCPDCDRSFSRSDHLALHRKRH 342

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG42741NP_611747.2 COG5048 <273..>352 CDD:227381 58/78 (74%)
zf-C2H2 280..304 CDD:278523 18/23 (78%)
C2H2 Zn finger 282..304 CDD:275368 17/21 (81%)
zf-H2C2_2 296..>313 CDD:290200 14/16 (88%)
C2H2 Zn finger 312..334 CDD:275368 18/21 (86%)
zf-H2C2_2 326..351 CDD:290200 18/24 (75%)
C2H2 Zn finger 342..362 CDD:275368 13/19 (68%)
KLF3NP_057615.3 Repressor domain 1..74 11/34 (32%)
KLF3_N 49..260 CDD:410554 57/284 (20%)
9aaTAD, inactive. /evidence=ECO:0000269|PubMed:31375868 60..68 5/7 (71%)
CTBP-binding motif 61..65 3/3 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 66..112 14/50 (28%)
zf-C2H2 260..284 CDD:395048 18/23 (78%)
C2H2 Zn finger 262..284 CDD:275368 17/21 (81%)
C2H2 Zn finger 292..314 CDD:275368 18/21 (86%)
zf-H2C2_2 306..331 CDD:404364 18/24 (75%)
C2H2 Zn finger 322..342 CDD:275368 13/19 (68%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 54 1.000 Domainoid score I11243
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000436
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR23235
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X1178
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
65.970

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