DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42741 and Klf2

DIOPT Version :9

Sequence 1:	NP_611747.2	Gene:	CG42741 / 37654	FlyBaseID:	FBgn0261705	Length:	362	Species:	Drosophila melanogaster
Sequence 2:	NP_001007685.1	Gene:	Klf2 / 306330	RGDID:	1359220	Length:	351	Species:	Rattus norvegicus

Alignment Length:	401	Identity:	114/401 - (28%)
Similarity:	144/401 - (35%)	Gaps:	137/401 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 FMNGLGSDPLSAKEAEGPPVQVEPVDLSLRSPRASTSHGSSSSSYKFSSANKAVGYSNGKPGGSS 67
            |:..:|.|.|.|:....||.|..|.......|.|...:|:                    |....
  Rat    46 FILSMGLDGLGAENPPEPPPQPPPPAFYYPEPGAPPPYGT--------------------PAAGL 90

  Fly    68 GSSSSSGFGAGSAGSSSLGAFAAQQQQQLYASSGVSKLPFSPFFAASPFFFTYRRISGSG----S 128
            |:...........|.:..|.|       |.|..|       ....|.|     ..:.|.|    :
  Rat    91 GTELLRPDLDAPQGPALHGRF-------LLAPPG-------RLVKAEP-----PEVDGGGYGCAA 136

  Fly   129 GNGTGSVSVKQEDNNNSCSYNNGSSSGGAGSAANSMQDYESKFSLLSLFKNPYKFAGGDGQASRK 193
            |...|...:|.|              |..|:....|:                      |.|.|.
  Rat   137 GLARGPRGLKLE--------------GALGATGACMR----------------------GPAGRP 165

  Fly   194 TSPTGGSSKPLASNSSPSWKSYAGSGSPHAALNPAFGGMGRGATRKDNSSFSGINFGGGGSAFGF 258
            ..|:  .:.||:.:..|.    ..:..|.....|.||              .|.:|||.|.|..:
  Rat   166 PPPS--DTPPLSPDGPPR----LPAPGPRNPFPPPFG--------------PGPSFGGPGPALHY 210

  Fly   259 TTSSDSMANGGYNDLS-------------------------------------KNRKVHKCDTEG 286
            ...:.. |.|.::|.:                                     |....|.|....
  Rat   211 GPPAPG-AFGLFDDAAAALGLAPPATRGLLTPPSSPLELLEAKPKRGRRSWPRKRAATHTCSYTN 274

  Fly   287 CDKVYTKSSHLKAHKRTHTGEKPYVCTWEGCIWRFARSDELTRHYRKHTGVKPFRCQLCTRSFSR 351
            |.|.||||||||||.|||||||||.|.|:||.|:||||||||||||||||.:||:|.||.|:|||
  Rat   275 CGKTYTKSSHLKAHLRTHTGEKPYHCNWDGCGWKFARSDELTRHYRKHTGHRPFQCHLCDRAFSR 339

  Fly   352 SDHLSLHMRRH 362
            ||||:|||:||
  Rat   340 SDHLALHMKRH 350

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42741	NP_611747.2	COG5048	<273..>352	CDD:227381	53/115 (46%)
		zf-C2H2	280..304	CDD:278523	15/23 (65%)
		C2H2 Zn finger	282..304	CDD:275368	14/21 (67%)
		zf-H2C2_2	296..>313	CDD:290200	14/16 (88%)
		C2H2 Zn finger	312..334	CDD:275368	17/21 (81%)
		zf-H2C2_2	326..351	CDD:290200	18/24 (75%)
		C2H2 Zn finger	342..362	CDD:275368	14/19 (74%)
Klf2	NP_001007685.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	20..110		15/83 (18%)
		9aaTAD. /evidence=ECO:0000250\|UniProtKB:Q9Y5W3	42..50		1/3 (33%)
		Interaction with WWP1. /evidence=ECO:0000250	110..264		35/229 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	156..209		18/94 (19%)
		COG5048	<266..346	CDD:227381	57/79 (72%)
		zf-C2H2	268..292	CDD:278523	15/23 (65%)
		C2H2 Zn finger	270..292	CDD:275368	14/21 (67%)
		zf-H2C2_2	284..>306	CDD:290200	17/21 (81%)
		C2H2 Zn finger	300..322	CDD:275368	17/21 (81%)
		zf-H2C2_2	314..339	CDD:290200	18/24 (75%)
		C2H2 Zn finger	330..350	CDD:275368	14/19 (74%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23235
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.010