DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42741 and Klf1

DIOPT Version :9

Sequence 1:	NP_611747.2	Gene:	CG42741 / 37654	FlyBaseID:	FBgn0261705	Length:	362	Species:	Drosophila melanogaster
Sequence 2:	XP_006255316.1	Gene:	Klf1 / 304666	RGDID:	1309398	Length:	381	Species:	Rattus norvegicus

Alignment Length:	388	Identity:	125/388 - (32%)
Similarity:	157/388 - (40%)	Gaps:	111/388 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 GPPVQVEP-VDLSLRS---------------------------------PRASTSHGSSSSSYKF 49
            |||...|| ..:||:|                                 ||......|.....:|
  Rat    60 GPPNPTEPSFHVSLKSEDPPGEDDERDVTCAWDPDLFLTNFSGPEPPSTPRTCALAPSGGPVAQF 124

  Fly    50 SSANKAVGYSNGKPG---GSSGSSSSSGFGAGSAGSSSLGAFAAQQQQQLYASSGVSKLPFSPFF 111
            :.......|:.| ||   |..||...:|:...:....:...|.|.              ..:|..
  Rat   125 APPESLSAYAGG-PGLVTGPLGSEEHAGWAHPTPRPPTPEPFVAP--------------VLAPGL 174

  Fly   112 A--ASPFFFTYRRISGSGSGNGTGSVSVKQEDNNNSCSYNNGSSSGGAGSAANSMQDYESKFSLL 174
            |  |.|.|...|.:|..|.....| ::|....   |..|  |..||  ..|......|:..|.|
  Rat   175 APKAQPAFSESRAVSAGGFFPRAG-LAVPAAP---SAPY--GLLSG--YPALYPAPQYQGHFQL- 230

  Fly   175 SLFKNPYKFAGGDGQASRKTSPTGGSSKPLASNSSPSWKSYAGSGSPHAALNPAFGGMGRGATRK 239
                    |.|       ..:|:.|.:.|      ||:.:..|.|:.         |...|||
  Rat   231 --------FRG-------LAAPSAGPTAP------PSFLNCLGPGAV---------GTELGAT-- 263

  Fly   240 DNSSFSGINFGGGGSAFGFTTSSDSMANGGYNDLSKNRKVHKCDTEGCDKVYTKSSHLKAHKRTH 304
               :.:| :.|....|.....|..::|       .|.:..|.|..|||.|.||||||||||.|||
  Rat   264 ---AIAG-DAGLSPGAAPPKRSRRTLA-------QKRQAAHTCGHEGCGKSYTKSSHLKAHLRTH 317

  Fly   305 T-----GEKPYVCTWEGCIWRFARSDELTRHYRKHTGVKPFRCQLCTRSFSRSDHLSLHMRRH 362
            |     |||||.|:|:||.||||||||||||||||||.:||.|.||.|:|||||||:|||:||
  Rat   318 TAPCPSGEKPYACSWDGCNWRFARSDELTRHYRKHTGHRPFCCGLCPRAFSRSDHLALHMKRH 380

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42741	NP_611747.2	COG5048	<273..>352	CDD:227381	56/83 (67%)
		zf-C2H2	280..304	CDD:278523	17/23 (74%)
		C2H2 Zn finger	282..304	CDD:275368	16/21 (76%)
		zf-H2C2_2	296..>313	CDD:290200	14/21 (67%)
		C2H2 Zn finger	312..334	CDD:275368	18/21 (86%)
		zf-H2C2_2	326..351	CDD:290200	18/24 (75%)
		C2H2 Zn finger	342..362	CDD:275368	14/19 (74%)
Klf1	XP_006255316.1	EKLF_TAD1	40..65	CDD:293437	3/4 (75%)
		EKLF_TAD2	81..103	CDD:293438	0/21 (0%)
		zf-C2H2	293..317	CDD:278523	17/23 (74%)
		COG5048	<297..>380	CDD:227381	61/82 (74%)
		C2H2 Zn finger	298..317	CDD:275368	15/18 (83%)
		zf-C2H2	328..352	CDD:278523	19/23 (83%)
		C2H2 Zn finger	330..352	CDD:275368	18/21 (86%)
		zf-H2C2_2	344..369	CDD:290200	18/24 (75%)
		C2H2 Zn finger	360..380	CDD:275368	14/19 (74%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23235
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010