DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42741 and wt1a

DIOPT Version :9

Sequence 1:	NP_611747.2	Gene:	CG42741 / 37654	FlyBaseID:	FBgn0261705	Length:	362	Species:	Drosophila melanogaster
Sequence 2:	NP_571121.1	Gene:	wt1a / 30245	ZFINID:	ZDB-GENE-980526-558	Length:	419	Species:	Danio rerio

Alignment Length:	410	Identity:	111/410 - (27%)
Similarity:	155/410 - (37%)	Gaps:	108/410 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 NGLGSDPLSAKEAEGPPVQVEPVDLSLRSPRASTSHGSSSSSYKFSSANKAVGYSNGKPGGSSGS 69
            ||..:.|:|: ..:.||:    :|....:|..|.      :.:.|.....:.|.::.......|.
Zfish    22 NGNCTLPVSS-TPQWPPM----LDFHTGAPYGSL------AQHSFIKQEPSWGTADPHEDPHCGL 75

  Fly    70 SS-----SSGF-GAGSAGSSSLGAFAAQQQQQLYASSGVSKLPFSP-FFAASPFFFTYRRISGSG 127
            |:     |..| |.|:....:.||.||.|..           |..| .|:.||:.........|.
Zfish    76 SAFTVHFSGQFTGTGACRYGAFGAPAASQPP-----------PSQPRMFSNSPYLSNCMDSQSSS 129

  Fly   128 SGNGTGSV----------------------------SVKQEDNNNSCSYNNGSSSGGAGSAANSM 164
            ...|.|:|                            |:.|:.|.....|.......|..:.::|.
Zfish   130 RNQGYGTVAFDGASNYGHTPSHHTPQFPNHSFKHEDSITQQSNMGDQQYPVPPPVYGCHTPSDSC 194

  Fly   165 QDYESKFSLLSLFKNPYKFAGGDGQ-ASR----------------KTSPTGGSSKPLASNSSPSW 212
            ..     |...|.:|||..:....| ||:                |:.|.|..|.|    |:|..
Zfish   195 TG-----SQALLLRNPYNSSDNLYQMASQLECMGWNPVNSLASTIKSHPGGYESDP----STPMV 250

  Fly   213 KSYAGSGSPHAALNPAFGGMGRGATRKDNSSFSGINFGGGGSAFGFTTSSDSMANGGYNDLSKNR 277
            .|.:.....|.      .|:.||.  :|.....||.     .|...:|.::            .:
Zfish   251 YSCSTQYRIHT------HGVFRGL--QDVRRVPGIT-----PAIVRSTETN------------EK 290

  Fly   278 KVHKCDTEGCDKVYTKSSHLKAHKRTHTGEKPYVCTWEGCIWRFARSDELTRHYRKHTGVKPFRC 342
            :...|...||:|.|.|.|||:.|.|.|||||||.|.:..|..||:|||:|.||.|:|||||||:|
Zfish   291 RPFMCAYPGCNKRYFKLSHLQMHSRKHTGEKPYQCDFTDCGRRFSRSDQLKRHQRRHTGVKPFQC 355

  Fly   343 QLCTRSFSRSDHLSLHMRRH 362
            :.|.|.|||||||..|.|.|
Zfish   356 ETCQRKFSRSDHLKTHTRTH 375

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42741	NP_611747.2	COG5048	<273..>352	CDD:227381	41/78 (53%)
		zf-C2H2	280..304	CDD:278523	11/23 (48%)
		C2H2 Zn finger	282..304	CDD:275368	11/21 (52%)
		zf-H2C2_2	296..>313	CDD:290200	11/16 (69%)
		C2H2 Zn finger	312..334	CDD:275368	11/21 (52%)
		zf-H2C2_2	326..351	CDD:290200	15/24 (63%)
		C2H2 Zn finger	342..362	CDD:275368	12/19 (63%)
wt1a	NP_571121.1	WT1	1..291	CDD:280348	62/324 (19%)
		COG5048	286..>411	CDD:227381	49/102 (48%)
		C2H2 Zn finger	298..317	CDD:275368	10/18 (56%)
		zf-H2C2_2	309..336	CDD:290200	15/26 (58%)
		C2H2 Zn finger	325..347	CDD:275368	11/21 (52%)
		zf-H2C2_2	340..364	CDD:290200	15/23 (65%)
		C2H2 Zn finger	355..375	CDD:275368	12/19 (63%)
		C2H2 Zn finger	386..408	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23235
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	3.010