Protein Alignment CG42741 and Klf4

DIOPT Version :10

• Sequence 1: NP_611747.2
• Gene: CG42741 / 37654
• FlyBaseID: FBgn0261705
• Length: 362
• Species: Drosophila melanogaster
• Sequence 2: NP_034767.2
• Gene: Klf4 / 16600
• MGIID: 1342287
• Length: 483
• Species: Mus musculus
• Alignment Length: 487
• Identity: 135/487 - (27%)
• Similarity: 179/487 - (36%)
• Gaps: 169/487 - (34%)

  Fly    17 AEGPPVQVEPVDLSLRSPRASTSHGSSSSSYKFSSANKAVGYSNGKP---GGSSGSSSSSGFGAG 78
            |.||..:    :.:||...|.|:......|:.     |.:....|:|   ..:..:...|| |||
Mouse    24 ASGPAGR----EKTLRPAGAPTNRWREELSHM-----KRLPPLPGRPYDLAATVATDLESG-GAG 78

  Fly    79 SAGSSSLGAFAAQQQQQLY-----------------------------ASSGVSKLPFSPFFAAS 114
            :|.||:..|..|:::.:.:                             |||..|.....|..|.|
Mouse    79 AACSSNNPALLARRETEEFNDLLDLDFILSNSLTHQESVAATVTTSASASSSSSPASSGPASAPS 143

  Fly   115 PFFFTYRRISGSGSG----NGTGSVSVKQEDNN------NSCSYNNGSSSGGAGSAANSMQDYES 169
            ...|:|...:|...|    |..|.:...:|...      |....|:.|.|||..:
Mouse   144 TCSFSYPIRAGGDPGVAASNTGGGLLYSRESAPPPTAPFNLADINDVSPSGGFVA---------- 198

  Fly   170 KFSLLSLFKNPYKFAGGDGQASRKTSPTGGS-----------SKPLASNSSPSWKSYA-GS--GS 220
              .||....:|...      ..::..|.||.           :.|.:..||||..|.: ||  ||
Mouse   199 --ELLRPELDPVYI------PPQQPQPPGGGLMGKFVLKASLTTPGSEYSSPSVISVSKGSPDGS 255

  Fly   221 PHAALNPAFGGMGR-------------GATRKDNSSFSG---INFGGGGSAFGF----------- 258
            ....:.|..||..|             ..:|...:..|.   ::.|...:...|
Mouse   256 HPVVVAPYSGGPPRMCPKIKQEAVPSCTVSRSLEAHLSAGPQLSNGHRPNTHDFPLGRQLPTRTT 320

  Fly   259 -TTSSDSMANG------------------------------------GYNDL------------- 273
             |.|.:.:.|.                                    .|.:|
Mouse   321 PTLSPEELLNSRDCHPGLPLPPGFHPHPGPNYPPFLPDQMQSQVPSLHYQELMPPGSCLPEEPKP 385

  Fly   274 --------SKNRKVHKCDTEGCDKVYTKSSHLKAHKRTHTGEKPYVCTWEGCIWRFARSDELTRH 330
                    .|....|.||..||.|.||||||||||.|||||||||.|.|:||.|:||||||||||
Mouse   386 KRGRRSWPRKRTATHTCDYAGCGKTYTKSSHLKAHLRTHTGEKPYHCDWDGCGWKFARSDELTRH 450

  Fly   331 YRKHTGVKPFRCQLCTRSFSRSDHLSLHMRRH 362
            ||||||.:||:||.|.|:|||||||:|||:||
Mouse   451 YRKHTGHRPFQCQKCDRAFSRSDHLALHMKRH 482

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42741	NP_611747.2	COG5048	<273..>352	CDD:227381	56/99 (57%)
		C2H2 Zn finger	282..304	CDD:275368	16/21 (76%)
		C2H2 Zn finger	312..334	CDD:275368	17/21 (81%)
		zf-H2C2_2	326..351	CDD:463886	18/24 (75%)
		C2H2 Zn finger	342..362	CDD:275368	14/19 (74%)
Klf4	NP_034767.2	KLF4_N	7..400	CDD:409228	71/403 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	22..42		6/21 (29%)
		9aaTAD. /evidence=ECO:0000250|UniProtKB:O43474	99..107		0/7 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	294..395		7/100 (7%)
		Interaction with ZNF296. /evidence=ECO:0000269|PubMed:24161396	386..483		65/97 (67%)
		COG5048	<395..478	CDD:227381	60/82 (73%)
		C2H2 Zn finger	402..424	CDD:275368	16/21 (76%)
		C2H2 Zn finger	432..454	CDD:275368	17/21 (81%)
		Interaction with target DNA	443..474		24/30 (80%)
		zf-H2C2_2	446..471	CDD:463886	18/24 (75%)
		C2H2 Zn finger	462..482	CDD:275368	14/19 (74%)