DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG42741 and Klf3

DIOPT Version :9

Sequence 1:NP_611747.2 Gene:CG42741 / 37654 FlyBaseID:FBgn0261705 Length:362 Species:Drosophila melanogaster
Sequence 2:NP_032479.1 Gene:Klf3 / 16599 MGIID:1342773 Length:344 Species:Mus musculus


Alignment Length:375 Identity:129/375 - (34%)
Similarity:166/375 - (44%) Gaps:93/375 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly     9 SDPLSAKEAEGPP-----VQVEPVDLSLRSPRASTSHGSSSSSYKFSSANKAVGYSNGKPGGSSG 68
            |.||..|..:.|.     :|||||||::....:..:.|.|.||.||.|..:|      .||.|..
Mouse    39 STPLPDKFFQTPEGLTHGIQVEPVDLTVNKRGSPPAAGGSPSSLKFPSHRRA------SPGLSMP 97

  Fly    69 SSSS--SGFGAGSAGSSSLG-------AFAAQQQQQLYASSGVSKLPFSPFFAASPFFFTYRRIS 124
            |||.  ..:...|.|....|       ..||...:....|.|:  ||........|..|.|    
Mouse    98 SSSPPIKKYSPPSPGVQPFGVPLSMPPVMAAALSRHGIRSPGI--LPVIQPVVVQPVPFMY---- 156

  Fly   125 GSGSGNGTG------SVSVKQE-DNNNSCSYNNGSSSGGAGSAANSMQDYESKFSLLSLFKNPYK 182
                   |.      .||:.:| ||:||            |.....::.||.     .|.:...|
Mouse   157 -------TSHLQQPLMVSLSEEMDNSNS------------GMPVPVIESYEK-----PLLQKKIK 197

  Fly   183 FAGGDGQASRKTSPTGGSSKPLASNSSPSWKSYAGSGSPHAALNPAFGGMGRGATRKDNSSFSGI 247
            ...|. :..|........|.||.:..||. ::......|...:.|     |:.....::.     
Mouse   198 IEPGI-EPQRTDYYPEEMSPPLMNPVSPP-QALLQENHPSVIVQP-----GKRPLPVESP----- 250

  Fly   248 NFGGGGSAFGFTTSSDSMANGGYNDLSKNRKVHKCDTEGCDKVYTKSSHLKAHKRTHTGEKPYVC 312
                                    |..:.|::|:||.:||:||||||||||||:|||||||||.|
Mouse   251 ------------------------DTQRKRRIHRCDYDGCNKVYTKSSHLKAHRRTHTGEKPYKC 291

  Fly   313 TWEGCIWRFARSDELTRHYRKHTGVKPFRCQLCTRSFSRSDHLSLHMRRH 362
            |||||.|:||||||||||:|||||:|||:|..|.|||||||||:||.:||
Mouse   292 TWEGCTWKFARSDELTRHFRKHTGIKPFQCPDCDRSFSRSDHLALHRKRH 341

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG42741NP_611747.2 COG5048 <273..>352 CDD:227381 58/78 (74%)
zf-C2H2 280..304 CDD:278523 18/23 (78%)
C2H2 Zn finger 282..304 CDD:275368 17/21 (81%)
zf-H2C2_2 296..>313 CDD:290200 14/16 (88%)
C2H2 Zn finger 312..334 CDD:275368 18/21 (86%)
zf-H2C2_2 326..351 CDD:290200 18/24 (75%)
C2H2 Zn finger 342..362 CDD:275368 13/19 (68%)
Klf3NP_032479.1 Repressor domain 1..74 12/34 (35%)
9aaTAD, inactive. /evidence=ECO:0000250|UniProtKB:P57682 60..68 5/7 (71%)
CTBP-binding motif 61..65 3/3 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 66..111 14/50 (28%)
COG5048 <169..>331 CDD:227381 79/214 (37%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 235..254 3/52 (6%)
C2H2 Zn finger 261..283 CDD:275368 17/21 (81%)
C2H2 Zn finger 291..313 CDD:275368 18/21 (86%)
zf-H2C2_2 305..330 CDD:372612 18/24 (75%)
C2H2 Zn finger 321..341 CDD:275368 13/19 (68%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 54 1.000 Domainoid score I11187
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000436
OrthoInspector 1 1.000 - - otm42933
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR23235
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X1178
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
76.970

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