DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG42741 and Klf12

DIOPT Version :9

Sequence 1:NP_611747.2 Gene:CG42741 / 37654 FlyBaseID:FBgn0261705 Length:362 Species:Drosophila melanogaster
Sequence 2:NP_034766.2 Gene:Klf12 / 16597 MGIID:1333796 Length:402 Species:Mus musculus


Alignment Length:398 Identity:136/398 - (34%)
Similarity:175/398 - (43%) Gaps:99/398 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly    11 PLSAKEAEGPP-----------VQVEPVDLSLRSPRASTSHGSSS-----SSYKFSSANKAVGYS 59
            ||.....:|.|           .|.||||||:...|.|.:..|||     :|....|:......|
Mouse    55 PLLLNNVKGEPPEDSLPVDHFQTQTEPVDLSINKARTSPTAASSSPVSMTASASSPSSTSTSSSS 119

  Fly    60 NGKPGG--------SSGSSSSSGFGAGS--AGSSSLGAFAAQQQQQLYASSGVSKLPFSPFFAAS 114
            :.:|..        ||.||||:....|.  |.:|.:|.     ||.|:....|.  |.||....|
Mouse   120 SSRPASSPTVITSVSSASSSSTVLSPGPLVASASGVGG-----QQFLHIIHPVP--PSSPMNLQS 177

  Fly   115 ----------------PFFFTYRRISGSGSGNGTGSVSVKQEDNNNSCSYNNGSSSGGAGSAANS 163
                            |..:|  .:...|:.|.|..|.:.::          |.|.|.|......
Mouse   178 NKLSHVHRIPVVVQSVPVVYT--AVRSPGNVNNTIVVPLLED----------GRSHGKAQMEPRG 230

  Fly   164 MQDYESKFSLLSLFKNPYKFAGGDGQASRKT----SPTGGSSKPLASNSSPSWKSYAGSGSPHAA 224
            :...:||..            ..|......|    :.||.::..:|....              .
Mouse   231 LSPRQSKSD------------SDDDDLPNVTLDSVNETGSTALSIARAVQ--------------E 269

  Fly   225 LNPAFGGMGRGATRKDNSSFSGINFGGGGSAFGFTTSSDSMANGGYNDLSKNRKVHKCDTEGCDK 289
            ::|:.....|| .|.:|..|:       .|...|:..|........:..|:.|::|:||.|||:|
Mouse   270 VHPSPVSRVRG-NRMNNQKFA-------CSISPFSIESTRRQRRSESPDSRKRRIHRCDFEGCNK 326

  Fly   290 VYTKSSHLKAHKRTHTGEKPYVCTWEGCIWRFARSDELTRHYRKHTGVKPFRCQLCTRSFSRSDH 354
            |||||||||||:|||||||||.||||||.|:||||||||||||||||||||:|..|.||||||||
Mouse   327 VYTKSSHLKAHRRTHTGEKPYKCTWEGCTWKFARSDELTRHYRKHTGVKPFKCADCDRSFSRSDH 391

  Fly   355 LSLHMRRH 362
            |:||.|||
Mouse   392 LALHRRRH 399

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG42741NP_611747.2 COG5048 <273..>352 CDD:227381 62/78 (79%)
zf-C2H2 280..304 CDD:278523 19/23 (83%)
C2H2 Zn finger 282..304 CDD:275368 18/21 (86%)
zf-H2C2_2 296..>313 CDD:290200 14/16 (88%)
C2H2 Zn finger 312..334 CDD:275368 19/21 (90%)
zf-H2C2_2 326..351 CDD:290200 20/24 (83%)
C2H2 Zn finger 342..362 CDD:275368 14/19 (74%)
Klf12NP_034766.2 KLF12_N 27..224 CDD:410608 47/187 (25%)
9aaTAD, inactive. /evidence=ECO:0000250|UniProtKB:Q9Y4X4 80..88 6/7 (86%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 81..144 20/62 (32%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 219..254 7/46 (15%)
COG5048 <225..401 CDD:227381 88/209 (42%)
C2H2 Zn finger 319..341 CDD:275368 18/21 (86%)
C2H2 Zn finger 349..371 CDD:275368 19/21 (90%)
zf-H2C2_2 363..388 CDD:404364 20/24 (83%)
C2H2 Zn finger 379..399 CDD:275368 14/19 (74%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 54 1.000 Domainoid score I11187
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - otm42933
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR23235
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X1178
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
65.970

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