DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42741 and Klf3

DIOPT Version :9

Sequence 1:	NP_611747.2	Gene:	CG42741 / 37654	FlyBaseID:	FBgn0261705	Length:	362	Species:	Drosophila melanogaster
Sequence 2:	NP_001099212.1	Gene:	Klf3 / 114845	RGDID:	1593290	Length:	344	Species:	Rattus norvegicus

Alignment Length:	375	Identity:	127/375 - (33%)
Similarity:	166/375 - (44%)	Gaps:	93/375 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 SDPLSAKEAEGPP-----VQVEPVDLSLRSPRASTSHGSSSSSYKFSSANKAVGYSNGKPGGSSG 68
            |.||..|..:.|.     :|:|||||::....:..|...|.||.||.|..:|      .||.|..
  Rat    39 STPLPDKFFQTPEGLAHGIQMEPVDLTVNKRGSPPSAAGSPSSLKFPSHRRA------SPGLSMP 97

  Fly    69 SSSS--SGFGAGSAGSSSLG-------AFAAQQQQQLYASSGVSKLPFSPFFAASPFFFTYRRIS 124
            |||.  ..:...|.|....|       ..||...:....|.|:  ||........|..|.|
  Rat    98 SSSPPIKKYSPPSPGVQPFGVPLSMPPVMAAALTRHGIRSPGI--LPVIQPVVVQPVPFMY---- 156

  Fly   125 GSGSGNGTG------SVSVKQE-DNNNSCSYNNGSSSGGAGSAANSMQDYESKFSLLSLFKNPYK 182
                   |.      .||:.:| ||:||            |.....::.||.     .:.:...|
  Rat   157 -------TSHLQQPLMVSLSEEMDNSNS------------GMPVPVIESYEK-----PILQKKIK 197

  Fly   183 FAGGDGQASRKTSPTGGSSKPLASNSSPSWKSYAGSGSPHAALNPAFGGMGRGATRKDNSSFSGI 247
            ...|. :..|........|.||.::.||. ::......|...:.|     |:.....::.
  Rat   198 IEPGI-EPQRTDYYPEEMSPPLMNSVSPP-QALLQENHPSVIVQP-----GKRPLPVESP----- 250

  Fly   248 NFGGGGSAFGFTTSSDSMANGGYNDLSKNRKVHKCDTEGCDKVYTKSSHLKAHKRTHTGEKPYVC 312
                                    |..:.|::|:||.:||:||||||||||||:|||||||||.|
  Rat   251 ------------------------DTQRKRRIHRCDYDGCNKVYTKSSHLKAHRRTHTGEKPYKC 291

  Fly   313 TWEGCIWRFARSDELTRHYRKHTGVKPFRCQLCTRSFSRSDHLSLHMRRH 362
            |||||.|:||||||||||:|||||:|||:|..|.|||||||||:||.:||
  Rat   292 TWEGCTWKFARSDELTRHFRKHTGIKPFQCPDCDRSFSRSDHLALHRKRH 341

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42741	NP_611747.2	COG5048	<273..>352	CDD:227381	58/78 (74%)
		zf-C2H2	280..304	CDD:278523	18/23 (78%)
		C2H2 Zn finger	282..304	CDD:275368	17/21 (81%)
		zf-H2C2_2	296..>313	CDD:290200	14/16 (88%)
		C2H2 Zn finger	312..334	CDD:275368	18/21 (86%)
		zf-H2C2_2	326..351	CDD:290200	18/24 (75%)
		C2H2 Zn finger	342..362	CDD:275368	13/19 (68%)
Klf3	NP_001099212.1	COG5048	<169..>331	CDD:227381	78/214 (36%)
		zf-C2H2	259..283	CDD:278523	18/23 (78%)
		C2H2 Zn finger	261..283	CDD:275368	17/21 (81%)
		zf-H2C2_2	275..>292	CDD:290200	14/16 (88%)
		C2H2 Zn finger	291..313	CDD:275368	18/21 (86%)
		zf-H2C2_2	305..330	CDD:290200	18/24 (75%)
		C2H2 Zn finger	321..341	CDD:275368	13/19 (68%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	54	1.000	Domainoid score	I10957
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	175	1.000	Inparanoid score	I3957
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000436
OrthoInspector	1	1.000	-	-		otm45002
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23235
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1178
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	9	9.020