DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42741 and Klf4

DIOPT Version :9

Sequence 1:	NP_611747.2	Gene:	CG42741 / 37654	FlyBaseID:	FBgn0261705	Length:	362	Species:	Drosophila melanogaster
Sequence 2:	NP_446165.1	Gene:	Klf4 / 114505	RGDID:	621445	Length:	482	Species:	Rattus norvegicus

Alignment Length:	427	Identity:	124/427 - (29%)
Similarity:	163/427 - (38%)	Gaps:	125/427 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 SDPLSAKEAEGPPVQVEPVDLSLRSPRASTSHGSSSSSYKFSSANKAVGYSNGKPGGSSGSSSSS 73
            |:.||.:|:....|.......|..|| ||:...|:.|:..||...:|    .|.||.::|::
  Rat   107 SNSLSHQESVAATVTTSASASSSSSP-ASSGPASAPSTCSFSYPIRA----GGDPGVAAGNT--- 163

  Fly    74 GFGAGSAGS-------------------SSLGAFAAQ-------------QQQQLYASSGVSKLP 106
              |.|...|                   |..|.|.|:             ||.|......:.|..
  Rat   164 --GGGLLYSRESAPPPTAPFNLADINDVSPSGGFVAELLRPELDPVYIPPQQPQPPGGGLMGKFV 226

  Fly   107 FSPFFAASPFFFTYRRISGSGSGNGTGS----------------VSVKQEDNNNSCSYNNGSSSG 155
            .....:.....:|...:.....|:..||                ..:||| ...||
  Rat   227 LKASLSTPGSEYTSPSVISVSKGSPDGSHPVVVAPYSGGPPRMCPKIKQE-AVPSC--------- 281

  Fly   156 GAGSAANSMQDYESKFSLLSLFKNP--YKFAGGDGQASRKTSPTGGSSKPLASNS-------SPS 211
               :.:.|::.:.|....||....|  :.|..| .|...:|:||....:.|.|..       .|.
  Rat   282 ---TVSRSLEAHLSAGPQLSNGHRPNTHDFPLG-RQLPTRTTPTLSPEELLNSRDCHPGLPLPPG 342

  Fly   212 WKSYAGSGSP---------------HAALNPAFGGMGRGATRKDNSSFSGINFGGGGSAFGFTTS 261
            :..:.|...|               :..|.|.                            |....
  Rat   343 FHPHPGPSYPPFLPDQMQSQVPSLHYQELMPP----------------------------GSCLP 379

  Fly   262 SDSMANGGYNDLSKNR-KVHKCDTEGCDKVYTKSSHLKAHKRTHTGEKPYVCTWEGCIWRFARSD 325
            .:.....|.....:.| ..|.||..||.|.||||||||||.|||||||||.|.|:||.|:|||||
  Rat   380 EEPKPKRGRRSWPRKRTATHTCDYAGCGKTYTKSSHLKAHLRTHTGEKPYHCDWDGCGWKFARSD 444

  Fly   326 ELTRHYRKHTGVKPFRCQLCTRSFSRSDHLSLHMRRH 362
            |||||||||||.:||:||.|.|:|||||||:|||:||
  Rat   445 ELTRHYRKHTGHRPFQCQKCDRAFSRSDHLALHMKRH 481

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42741	NP_611747.2	COG5048	<273..>352	CDD:227381	55/79 (70%)
		zf-C2H2	280..304	CDD:278523	17/23 (74%)
		C2H2 Zn finger	282..304	CDD:275368	16/21 (76%)
		zf-H2C2_2	296..>313	CDD:290200	14/16 (88%)
		C2H2 Zn finger	312..334	CDD:275368	17/21 (81%)
		zf-H2C2_2	326..351	CDD:290200	18/24 (75%)
		C2H2 Zn finger	342..362	CDD:275368	14/19 (74%)
Klf4	NP_446165.1	COG5048	<394..477	CDD:227381	60/82 (73%)
		zf-C2H2	399..423	CDD:278523	17/23 (74%)
		C2H2 Zn finger	401..423	CDD:275368	16/21 (76%)
		C2H2 Zn finger	431..453	CDD:275368	17/21 (81%)
		zf-H2C2_2	445..470	CDD:290200	18/24 (75%)
		C2H2 Zn finger	461..481	CDD:275368	14/19 (74%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23235
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.010