DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42741 and KLF12

DIOPT Version :9

Sequence 1:	NP_611747.2	Gene:	CG42741 / 37654	FlyBaseID:	FBgn0261705	Length:	362	Species:	Drosophila melanogaster
Sequence 2:	XP_011533209.1	Gene:	KLF12 / 11278	HGNCID:	6346	Length:	415	Species:	Homo sapiens

Alignment Length:	413	Identity:	135/413 - (32%)
Similarity:	171/413 - (41%)	Gaps:	129/413 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 PLSAKEAEGPP-----------VQVEPVDLSLRSPRASTSHGSSSSSYKFSSANKAVGYSNGKPG 64
            ||.....:|.|           .|.||||||:...|.|.:..|||.....:||:        .|.
Human    68 PLLLNNVKGEPPEDSLSVDHFQTQTEPVDLSINKARTSPTAVSSSPVSMTASAS--------SPS 124

  Fly    65 GSSGSSSSSG---------FGAGSAGSSSL----GAFAAQQQQQLYASSGVSKLPF----SPFFA 112
            .:|.|||||.         ....||.|||.    |...|       ::|||....|    .|...
Human   125 STSTSSSSSSRLASSPTVITSVSSASSSSTVLTPGPLVA-------SASGVGGQQFLHIIHPVPP 182

  Fly   113 ASPFFF--------------------TYRRISGSGSGNGTGSVSVKQEDNNNSCSYNNGSSSGGA 157
            :||...                    .|..:...|:.|.|..|.:.::
Human   183 SSPMNLQSNKLSHVHRIPVVVQSVPVVYTAVRSPGNVNNTIVVPLLED----------------- 230

  Fly   158 GSAANSMQDYESKFSLLSLFKNPYKFAGGDGQASRKTSPTGGSSKPLASNS------SPSWKSYA 216
                                        |.|....:..|.|.|.:...|:|      :.:..|..
Human   231 ----------------------------GRGHGKAQMDPRGLSPRQSKSDSDDDDLPNVTLDSVN 267

  Fly   217 GSGSPHAAL-------NPAFGGMGRGATRKDNSSFSGINFGGGGSAFGFTTSSDSMANGGYNDLS 274
            .:||...::       :|:.....|| .|.:|..|.       .|...|:..|........:..|
Human   268 ETGSTALSIARAVQEVHPSPVSRVRG-NRMNNQKFP-------CSISPFSIESTRRQRRSESPDS 324

  Fly   275 KNRKVHKCDTEGCDKVYTKSSHLKAHKRTHTGEKPYVCTWEGCIWRFARSDELTRHYRKHTGVKP 339
            :.|::|:||.|||:||||||||||||:|||||||||.||||||.|:|||||||||||||||||||
Human   325 RKRRIHRCDFEGCNKVYTKSSHLKAHRRTHTGEKPYKCTWEGCTWKFARSDELTRHYRKHTGVKP 389

  Fly   340 FRCQLCTRSFSRSDHLSLHMRRH 362
            |:|..|.|||||||||:||.|||
Human   390 FKCADCDRSFSRSDHLALHRRRH 412

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42741	NP_611747.2	COG5048	<273..>352	CDD:227381	62/78 (79%)
		zf-C2H2	280..304	CDD:278523	19/23 (83%)
		C2H2 Zn finger	282..304	CDD:275368	18/21 (86%)
		zf-H2C2_2	296..>313	CDD:290200	14/16 (88%)
		C2H2 Zn finger	312..334	CDD:275368	19/21 (90%)
		zf-H2C2_2	326..351	CDD:290200	20/24 (83%)
		C2H2 Zn finger	342..362	CDD:275368	14/19 (74%)
KLF12	XP_011533209.1	COG5048	<241..414	CDD:227381	89/180 (49%)
		zf-C2H2	330..354	CDD:278523	19/23 (83%)
		C2H2 Zn finger	332..354	CDD:275368	18/21 (86%)
		zf-H2C2_2	346..>363	CDD:290200	14/16 (88%)
		C2H2 Zn finger	362..384	CDD:275368	19/21 (90%)
		zf-H2C2_2	376..401	CDD:290200	20/24 (83%)
		C2H2 Zn finger	392..412	CDD:275368	14/19 (74%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	54	1.000	Domainoid score	I11243
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	205	1.000	Inparanoid score	I3725
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23235
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1178
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	6	6.020