DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42741 and klf12b

DIOPT Version :9

Sequence 1:	NP_611747.2	Gene:	CG42741 / 37654	FlyBaseID:	FBgn0261705	Length:	362	Species:	Drosophila melanogaster
Sequence 2:	NP_001103335.1	Gene:	klf12b / 100126139	ZFINID:	ZDB-GENE-071004-22	Length:	341	Species:	Danio rerio

Alignment Length:	407	Identity:	134/407 - (32%)
Similarity:	165/407 - (40%)	Gaps:	157/407 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 LSAKEAEGP---------PVQVEPVDLSLRSPRAST--SHGS--------SSSSYKFSSANKAVG 57
            ||..:||.|         ..|.||||||:...|.|:  |:.|        ||||...||.:....
Zfish    33 LSKVKAEPPEDLLSSDQFQTQTEPVDLSINKTRTSSPLSNNSPVTSAFSPSSSSSSSSSPSVIAS 97

  Fly    58 YSNGKPGGSSGSSSSSGFGAGSAGSSSLGAFAAQQQQQLY-----ASSGVSKLP-----FSPFFA 112
            .|:|.|         |...:||...||.|   .:.||.|:     ..|..||||     .|....
Zfish    98 VSSGMP---------SVLTSGSLVGSSHG---VRGQQFLHIIHPVPPSSPSKLPSQVHRISVVVQ 150

  Fly   113 ASPFFFTYRRISGS---------------------GSGNGTGSVSVKQEDNNNSC------SYNN 150
            :.|..:|....|.|                     ...||.....:|.:.:::..      |.|.
Zfish   151 SLPLMYTTSVRSPSTLSSTIMLPLLDEARCQDKAQTDPNGLSPRQIKSDSDDDDLPNVTLDSVNE 215

  Fly   151 GSSSGGAGSAANSMQDYESKFSLLSLFKNPYKFAGGDGQASRKTSPTGGSSKPLASNSSPSWKSY 215
            ..|:  |.|.|.::||..|.||:.|:               |:..|.          .||.
Zfish   216 TGST--ALSIARAVQDSMSPFSIESI---------------RRPPPP----------ESPD---- 249

  Fly   216 AGSGSPHAALNPAFGGMGRGATRKDNSSFSGINFGGGGSAFGFTTSSDSMANGGYNDLSKNRKVH 280
                                                                      ||.|::|
Zfish   250 ----------------------------------------------------------SKKRRIH 256

  Fly   281 KCDTEGCDKVYTKSSHLKAHKRTHTGEKPYVCTWEGCIWRFARSDELTRHYRKHTGVKPFRCQLC 345
            :||..||:||||||||||||:|||||||||.|||:||.|:||||||||||||||||||||:|..|
Zfish   257 RCDFAGCNKVYTKSSHLKAHRRTHTGEKPYKCTWDGCTWKFARSDELTRHYRKHTGVKPFKCGDC 321

  Fly   346 TRSFSRSDHLSLHMRRH 362
            .|||||||||:||.|||
Zfish   322 DRSFSRSDHLALHRRRH 338

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42741	NP_611747.2	COG5048	<273..>352	CDD:227381	61/78 (78%)
		zf-C2H2	280..304	CDD:278523	18/23 (78%)
		C2H2 Zn finger	282..304	CDD:275368	17/21 (81%)
		zf-H2C2_2	296..>313	CDD:290200	14/16 (88%)
		C2H2 Zn finger	312..334	CDD:275368	18/21 (86%)
		zf-H2C2_2	326..351	CDD:290200	20/24 (83%)
		C2H2 Zn finger	342..362	CDD:275368	14/19 (74%)
klf12b	NP_001103335.1	zf-C2H2	256..280	CDD:278523	18/23 (78%)
		C2H2 Zn finger	258..280	CDD:275368	17/21 (81%)
		zf-H2C2_2	272..>289	CDD:290200	14/16 (88%)
		C2H2 Zn finger	288..310	CDD:275368	18/21 (86%)
		zf-H2C2_2	302..327	CDD:290200	20/24 (83%)
		C2H2 Zn finger	318..338	CDD:275368	14/19 (74%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	58	1.000	Domainoid score	I10737
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	202	1.000	Inparanoid score	I3723
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23235
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1178
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	6	6.020