Protein Alignment ReepA and REEP4

DIOPT Version :9

• Sequence 1: NP_001188988.1
• Gene: ReepA / 37643
• FlyBaseID: FBgn0261564
• Length: 716
• Species: Drosophila melanogaster
• Sequence 2: NP_079508.2
• Gene: REEP4 / 80346
• HGNCID: 26176
• Length: 257
• Species: Homo sapiens
• Alignment Length: 337
• Identity: 121/337 - (35%)
• Similarity: 159/337 - (47%)
• Gaps: 97/337 - (28%)

  Fly   135 ICSLIVIFLAPRTCAQSLLFPAFRLFCGTLYPAYASYKAVRTKDVKEYVKWMMYWIVFAFFTCIE 199
            ||.|:|           |:|       |.|.|||||||||:||:::|||:|||||||||.|...|
Human     6 ICRLVV-----------LVF-------GMLCPAYASYKAVKTKNIREYVRWMMYWIVFALFMAAE 52

  Fly   200 TFTDIFISWLPFYYEVKVALVFWLLSPATKGSSTLYRKFVHPMLTRHEQEIDEYVNQAKERGYSA 264
            ..|||||||.|||||:|:|.|.|||||.|||:|.||||||||.|:|||:|||.|:.|||||.|..
Human    53 IVTDIFISWFPFYYEIKMAFVLWLLSPYTKGASLLYRKFVHPSLSRHEKEIDAYIVQAKERSYET 117

  Fly   265 VLQLGSKGVNYATNVLMQTAIKGGGNLVQTIKRSYSLSDLSE------PDMHRTQDELDDVMMSS 323
            ||..|.:|:|.|.:..:|.|.|..|.|...: ||:|:.||..      |..|      |.:.:..
Human   118 VLSFGKRGLNIAASAAVQAATKSQGALAGRL-RSFSMQDLRSISDAPAPAYH------DPLYLED 175

  Fly   324 MTSSAVVMRSTATGARLLRPRNQTPVGRSGSGTRHSTGMYFTEVDVTAKNAGDFNYNIRSQDDIS 388
            ..|..             ||    |:|....|.:.|.                      ::|:.
Human   176 QVSHR-------------RP----PIGYRAGGLQDSD----------------------TEDEC- 200

  Fly   389 SGYSSAEPVSGLSRTSSMTNASKARAKSKRNELLEEMRDEVYLDNQLYFQGVQRKSSVPE--AEE 451
              :|..|.|            .:|.|:.:...|:......|          |:||..|.|  :..
Human   201 --WSDTEAV------------PRAPARPREKPLIRSQSLRV----------VKRKPPVREGTSRS 241

  Fly   452 LKIVESSESIQS 463
            ||:....:::.|
Human   242 LKVRTRKKTVPS 253

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ReepA	NP_001188988.1	TB2_DP1_HVA22	158..241	CDD:281172	57/82 (70%)
REEP4	NP_079508.2	TB2_DP1_HVA22	19..94	CDD:308643	55/74 (74%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	183..257		20/118 (17%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	136	1.000	Domainoid score	I4920
eggNOG	1	0.900	-	-		E1_COG5052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1473891at2759
OrthoFinder	1	1.000	-	-		FOG0000584
OrthoInspector	1	1.000	-	-		otm40322
orthoMCL	1	0.900	-	-		OOG6_102704
Panther	1	1.100	-	-	LDO	PTHR12300
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2950
SonicParanoid	1	1.000	-	-		X586
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.850