DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ReepA and Reep4

DIOPT Version :9

Sequence 1:	NP_001188988.1	Gene:	ReepA / 37643	FlyBaseID:	FBgn0261564	Length:	716	Species:	Drosophila melanogaster
Sequence 2:	XP_006519661.1	Gene:	Reep4 / 72549	MGIID:	1919799	Length:	293	Species:	Mus musculus

Alignment Length:	267	Identity:	108/267 - (40%)
Similarity:	133/267 - (49%)	Gaps:	84/267 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   135 ICSLIVIFLAPRTCAQSLLFPAFRLFCGTLYPAYASYKAVRTKDVKEYVKWMMYWIVFAFFTCIE 199
            ||.|:|           |:|       |.|||||||||||::|:::|||:|||||||||.|...|
Mouse     6 ICRLVV-----------LIF-------GMLYPAYASYKAVKSKNIREYVRWMMYWIVFAIFMAAE 52

  Fly   200 TFTDIFISW------------------------------------LPFYYEVKVALVFWLLSPAT 228
            |||||||||                                    .|||||.|:|.|.|||||.|
Mouse    53 TFTDIFISWSGPRIGRPWGWEGPHHHHHHHLASGSHKPLPLLTHRFPFYYEFKMAFVLWLLSPYT 117

  Fly   229 KGSSTLYRKFVHPMLTRHEQEIDEYVNQAKERGYSAVLQLGSKGVNYATNVLMQTAIKGGGNLVQ 293
            ||:|.||||||||.|:|||:|||..:.|||||.|..:|..|.:.:|.|.:..:|.|.|..|.|..
Mouse   118 KGASLLYRKFVHPSLSRHEKEIDACIVQAKERSYETMLSFGKRSLNIAASAAVQAATKSQGALAG 182

  Fly   294 TIKRSYSLSDL-SEPD--MHRTQDEL---DDVMMSSMTSSAVVMRSTATGARLLRPRNQTPVGRS 352
            .: ||:|:.|| |.||  :...||.|   |.|                       ||.:.|:|..
Mouse   183 RL-RSFSMQDLRSIPDTPVPTYQDPLYLEDQV-----------------------PRRRPPIGYR 223

  Fly   353 GSGTRHS 359
            ..|.:.|
Mouse   224 PGGLQGS 230

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ReepA	NP_001188988.1	TB2_DP1_HVA22	158..241	CDD:281172	59/118 (50%)
Reep4	XP_006519661.1	TB2_DP1_HVA22	19..130	CDD:367349	56/110 (51%)
Reep4	XP_006519661.1	PRK11675	<247..>279	CDD:183272
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	137	1.000	Domainoid score	I4856
eggNOG	1	0.900	-	-		E1_COG5052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1473891at2759
OrthoFinder	1	1.000	-	-		FOG0000584
OrthoInspector	1	1.000	-	-		otm42387
orthoMCL	1	0.900	-	-		OOG6_102704
Panther	1	1.100	-	-	LDO	PTHR12300
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2950
SonicParanoid	1	1.000	-	-		X586
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.850