DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ReepA and REEP1

DIOPT Version :9

Sequence 1:	NP_001188988.1	Gene:	ReepA / 37643	FlyBaseID:	FBgn0261564	Length:	716	Species:	Drosophila melanogaster
Sequence 2:	NP_001358208.1	Gene:	REEP1 / 65055	HGNCID:	25786	Length:	284	Species:	Homo sapiens

Alignment Length:	202	Identity:	98/202 - (48%)
Similarity:	123/202 - (60%)	Gaps:	34/202 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   159 LFCGTLYPAYASYKAVRTKDVKEYVKWMMYWIVFAFFTCIETFTDIFISWLPFYYEVKVALVFWL 223
            |..|||||||.|||||::||:|||||||||||:||.||..|||||||:.|.|||||:|:|.|.||
Human    12 LIFGTLYPAYYSYKAVKSKDIKEYVKWMMYWIIFALFTTAETFTDIFLCWFPFYYELKIAFVAWL 76

  Fly   224 LSPATKGSSTLYRKFVHPMLTRHEQEIDEYVNQAKERGYSAVLQLGSKGVNYATNVLMQTAIKGG 288
            |||.|||||.||||||||.|:..|:|||:.:.|||:|.|.|::..|.:|:|.|....:..|.||.
Human    77 LSPYTKGSSLLYRKFVHPTLSSKEKEIDDCLVQAKDRSYDALVHFGKRGLNVAATAAVMAASKGQ 141

  Fly   289 GNLVQTIKRSYSLSDLS--------------------------EPDMHRTQDELDDVMMSSMTSS 327
            |.|.:.: ||:|:.||:                          :|.|.|:..|       |.:||
Human   142 GALSERL-RSFSMQDLTTIRGDGAPAPSGPPPPGSGRASGKHGQPKMSRSASE-------SASSS 198

  Fly   328 AVVMRST 334
            .....||
Human   199 VCTCCST 205

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ReepA	NP_001188988.1	TB2_DP1_HVA22	158..241	CDD:281172	62/81 (77%)
REEP1	NP_001358208.1	TB2_DP1_HVA22	19..94	CDD:367349	57/74 (77%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	136	1.000	Domainoid score	I4920
eggNOG	1	0.900	-	-		E1_COG5052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1473891at2759
OrthoFinder	1	1.000	-	-		FOG0000584
OrthoInspector	1	1.000	-	-		otm40322
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2950
SonicParanoid	1	1.000	-	-		X586
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.850