Protein Alignment ReepA and Reep5

DIOPT Version :10

• Sequence 1: NP_001188988.1
• Gene: ReepA / 37643
• FlyBaseID: FBgn0261564
• Length: 716
• Species: Drosophila melanogaster
• Sequence 2: NP_001102358.2
• Gene: Reep5 / 364838
• RGDID: 1306047
• Length: 189
• Species: Rattus norvegicus
• Alignment Length: 157
• Identity: 49/157 - (31%)
• Similarity: 83/157 - (52%)
• Gaps: 14/157 - (8%)

  Fly   129 SFNTACICSLIVIFLAPRTCAQSLLFPAFRLFCGTL---YPAYASYKAVRTKDVKEYVKWMMYWI 190
            ||....:..|:.::|.....|.        |.|..:   ||||.|.||:.:.:..:..:|:.||:
  Rat    35 SFIALGVIGLVALYLVFGYGAS--------LLCNLIGFGYPAYISMKAIESPNKDDDTQWLTYWV 91

  Fly   191 VFAFFTCIETFTDIFISWLPFYYEVKVALVFWLLSPA-TKGSSTLYRKFVHPMLTRHEQEIDEYV 254
            |:..|:..|.|:|:|:||.||||.:|...:.|.::|: :.|:..|||:.:.|:..:||.::|..|
  Rat    92 VYGVFSIAEFFSDLFLSWFPFYYMLKCGFLLWCMAPSPSNGAELLYRRVIRPIFLKHESQVDSVV 156

  Fly   255 NQAKERGYSAVLQLGSKGVNYAT-NVL 280
            ...|::.......: ||.|..|| |:|
  Rat   157 KDVKDKAKETADAI-SKEVKKATVNLL 182

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ReepA	NP_001188988.1	TB2_DP1_HVA22	166..242	CDD:460820	28/76 (37%)
Reep5	NP_001102358.2	TB2_DP1_HVA22	67..144	CDD:460820	28/76 (37%)
		Required for dimerization and maintaining endoplasmic reticulum morphology. /evidence=ECO:0000250|UniProtKB:Q00765	114..185		21/70 (30%)