Protein Alignment ReepA and REEP3

DIOPT Version :10

• Sequence 1: NP_001188988.1
• Gene: ReepA / 37643
• FlyBaseID: FBgn0261564
• Length: 716
• Species: Drosophila melanogaster
• Sequence 2: NP_001001330.1
• Gene: REEP3 / 221035
• HGNCID: 23711
• Length: 255
• Species: Homo sapiens
• Alignment Length: 286
• Identity: 105/286 - (36%)
• Similarity: 152/286 - (53%)
• Gaps: 49/286 - (17%)

  Fly   159 LFCGTLYPAYASYKAVRTKDVKEYVKWMMYWIVFAFFTCIETFTDIFISWLPFYYEVKVALVFWL 223
            |..|.|||||.|||||:||:|||||:|||||||||.:|.|||..|..::|.|.|||:|:|.|.||
Human    12 LVFGMLYPAYYSYKAVKTKNVKEYVRWMMYWIVFALYTVIETVADQTVAWFPLYYELKIAFVIWL 76

  Fly   224 LSPATKGSSTLYRKFVHPMLTRHEQEIDEYVNQAKERGYSAVLQLGSKGVNYATNVLMQTAIKGG 288
            |||.|||:|.:||||:||:|:..|:|||:|:.|||||||..::..|.:|:|.|....:..|:|..
Human    77 LSPYTKGASLIYRKFLHPLLSSKEREIDDYIVQAKERGYETMVNFGRQGLNLAATAAVTAAVKSQ 141

  Fly   289 GNLVQTIKRSYSLSDLS-----EPDMHRTQDELDDVMMSSMTSSAVVMRSTATGARLLRPRNQTP 348
            |.:.:.: ||:|:.||:     ||...|....|.:....|                  :|   .|
Human   142 GAITERL-RSFSMHDLTTIQGDEPVGQRPYQPLPEAKKKS------------------KP---AP 184

  Fly   349 VGRSGSGTRHSTGMYFTEVDVTAKNAGDFNYNIRSQDDISSGYSSAEPVS--GLSRTSSMTNASK 411
            ...:|.|             :..|:..:     ::.::....||..|.::  ||.|:.||  .|.
Human   185 SESAGYG-------------IPLKDGDE-----KTDEEAEGPYSDNEMLTHKGLRRSQSM--KSV 229

  Fly   412 ARAKSKRNELLEEMRDEVYLDNQLYF 437
            ...|.::......::.:|....|:||
Human   230 KTTKGRKEVRYGSLKYKVKKRPQVYF 255

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ReepA	NP_001188988.1	TB2_DP1_HVA22	166..242	CDD:460820	51/75 (68%)
REEP3	NP_001001330.1	TB2_DP1_HVA22	19..95	CDD:460820	51/75 (68%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	158..242		20/124 (16%)