DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3700 and TMPRSS5

DIOPT Version :9

Sequence 1:	NP_611736.1	Gene:	CG3700 / 37640	FlyBaseID:	FBgn0034796	Length:	360	Species:	Drosophila melanogaster
Sequence 2:	NP_110397.2	Gene:	TMPRSS5 / 80975	HGNCID:	14908	Length:	457	Species:	Homo sapiens

Alignment Length:	274	Identity:	80/274 - (29%)
Similarity:	122/274 - (44%)	Gaps:	46/274 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    94 SACQSTPF---IVGGTKASGKEFPFMALIGTHRPNKSKSDINWDCGGSVVHPKFVLTAAHCLETD 155
            |.|.:.|.   ||||...:...:|:.|.:..        .....|||||:.|::|:|||||:.:
Human   207 SECGARPLASRIVGGQSVAPGRWPWQASVAL--------GFRHTCGGSVLAPRWVVTAAHCMHS- 262

  Fly   156 ESKAERLDPNFDSPKFVVRLGELDYNSTT--DDALVQDFRVVNYVVHPGYDTEDEEQGFKNDIAL 218
             .:..||.      .:.|..|.:.:::..  ..|||:     ..:.||.|..::.:.    |:||
Human   263 -FRLARLS------SWRVHAGLVSHSAVRPHQGALVE-----RIIPHPLYSAQNHDY----DVAL 311

  Fly   219 VELDRKAEFNDHVAAVCLPPDSGN--DVQQVTAAGWGFT--ADGVKSSHLLKVNLQRFSDEVCQK 279
            :.|.....|:|.|.|||||....:  ...:...:|||.|  :....|..|....:..||.::|..
Human   312 LRLQTALNFSDTVGAVCLPAKEQHFPKGSRCWVSGWGHTHPSHTYSSDMLQDTVVPLFSTQLCNS 376

  Fly   280 RLRFS-IDTRTQFCAGSMSSQADTCNGDSGGPIFVQHPLYPC----LKQVIGIVSYGLVCGSQGL 339
            ...:| ..|....|||.:..:||.|.||||||:.       |    ..:::|:||:|..|.....
Human   377 SCVYSGALTPRMLCAGYLDGRADACQGDSGGPLV-------CPDGDTWRLVGVVSWGRGCAEPNH 434

  Fly   340 PSVYTKVHLYTDWI 353
            |.||.||..:.|||
Human   435 PGVYAKVAEFLDWI 448

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3700	NP_611736.1	Tryp_SPc	102..356	CDD:238113	77/263 (29%)
CG3700	NP_611736.1	Tryp_SPc	102..353	CDD:214473	75/261 (29%)
TMPRSS5	NP_110397.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
		SRCR_2	116..213	CDD:292133	2/5 (40%)
		Tryp_SPc	217..448	CDD:214473	75/262 (29%)
		Tryp_SPc	218..451	CDD:238113	77/263 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910