DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3700 and C1S

DIOPT Version :9

Sequence 1:	NP_611736.1	Gene:	CG3700 / 37640	FlyBaseID:	FBgn0034796	Length:	360	Species:	Drosophila melanogaster
Sequence 2:	NP_001725.1	Gene:	C1S / 716	HGNCID:	1247	Length:	688	Species:	Homo sapiens

Alignment Length:	389	Identity:	98/389 - (25%)
Similarity:	149/389 - (38%)	Gaps:	128/389 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 VTEYCDNGTGECKELTPSDCPVIFYNQHLIGAEVKY-CDE---------------------FNDI 61
            :.|..:||..|..|.|            |.|:.::| |:|                     .|::
Human   361 IPESIENGKVEDPEST------------LFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEV 413

  Fly    62 V------C---CPIPLDHQNLKPAEQTRPFEKQCKQYNEVRSACQSTPFIVGGTKASGKEFPFMA 117
            :      |   |.:|.:           |||::.:              |:||:.|..|.||:..
Human   414 LGPELPKCVPVCGVPRE-----------PFEEKQR--------------IIGGSDADIKNFPWQV 453

  Fly   118 LIGTHRPNKSKSDINWDCGGSVVHPKFVLTAAHCLETDESKAERLDPNFDSPKFVVRLGELDYNS 182
            ..          |..| .||::::..:||||||.:|.:.      :|..             |..
Human   454 FF----------DNPW-AGGALINEYWVLTAAHVVEGNR------EPTM-------------YVG 488

  Fly   183 TTDDALVQDFRVV--------NYVVHPGYDTEDEEQG---FKNDIALVELDRKAEFNDHVAAVCL 236
            :|.   ||..|:.        :..:|||:...:..:|   |.||||||.|....:....|:.:||
Human   489 STS---VQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICL 550

  Fly   237 PPDSGN----DVQQVTAAGWGFT-----ADGVKSSHLLKVNLQRFSDEVCQKRLRFS---IDTRT 289
            |..|.:    |......:|||.|     |..:|::.|....|::..:...:|....:   :.|..
Human   551 PGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPN 615

  Fly   290 QFCAGSMSSQADTCNGDSGGPIFVQHPLYPCLKQVIGIVSYGLVCGSQGLPSVYTKVHLYTDWI 353
            ..|||..... |:|.|||||...||.|.........|:||:|..||:.||   ||:|..|.|||
Human   616 MICAGGEKGM-DSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGL---YTRVKNYVDWI 675

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3700	NP_611736.1	Tryp_SPc	102..356	CDD:238113	80/275 (29%)
CG3700	NP_611736.1	Tryp_SPc	102..353	CDD:214473	78/273 (29%)
C1S	NP_001725.1	CUB	18..129	CDD:238001
		FXa_inhibition	143..171	CDD:405372
		CUB	175..287	CDD:395345
		CCP	294..355	CDD:153056
		Sushi	359..421	CDD:395037	12/71 (17%)
		Tryp_SPc	438..678	CDD:238113	80/275 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910