DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3700 and TMPRSS2

DIOPT Version :9

Sequence 1:	NP_611736.1	Gene:	CG3700 / 37640	FlyBaseID:	FBgn0034796	Length:	360	Species:	Drosophila melanogaster
Sequence 2:	NP_001128571.1	Gene:	TMPRSS2 / 7113	HGNCID:	11876	Length:	529	Species:	Homo sapiens

Alignment Length:	349	Identity:	94/349 - (26%)
Similarity:	146/349 - (41%)	Gaps:	86/349 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 DNGTGECKELTPSDCPVIFYNQ--HLIGAEVKYCDEFNDIVCCPIPLDHQNLKPAEQTRPFEKQC 86
            |:|:....:|..|...|..|.:  |......|.......|.|      ..||..:.|:|
Human   240 DSGSTSFMKLNTSAGNVDIYKKLYHSDACSSKAVVSLRCIAC------GVNLNSSRQSR------ 292

  Fly    87 KQYNEVRSACQSTPFIVGGTKASGKEFPFMALIGTHRPNKSKSDINWDCGGSVVHPKFVLTAAHC 151
                           ||||..|....:|:.  :..|..|...      ||||::.|::::|||||
Human   293 ---------------IVGGESALPGAWPWQ--VSLHVQNVHV------CGGSIITPEWIVTAAHC 334

  Fly   152 LETDESKAERLDPNFDSPKF--VVRLGELDYNSTTDDALVQDFRVVNYVVHPGYDTEDEEQGFKN 214
            :|      :.|:..:....|  ::|...:.|.:        .::|...:.||.||::.:    .|
Human   335 VE------KPLNNPWHWTAFAGILRQSFMFYGA--------GYQVEKVISHPNYDSKTK----NN 381

  Fly   215 DIALVELDRKAEFNDHVAAVCLP-------PDSGNDVQQVTAAGWGFTADGVKSSHLLK------ 266
            ||||::|.:...|||.|..||||       |:     |....:|||.|.:..|:|.:|.
Human   382 DIALMKLQKPLTFNDLVKPVCLPNPGMMLQPE-----QLCWISGWGATEEKGKTSEVLNAAKVLL 441

  Fly   267 VNLQRFSDEVCQKRLRF-SIDTRTQFCAGSMSSQADTCNGDSGGPIFV-QHPLYPCLKQVIGIVS 329
            :..||     |..|..: ::.|....|||.:....|:|.||||||:.. ::.::    .:||..|
Human   442 IETQR-----CNSRYVYDNLITPAMICAGFLQGNVDSCQGDSGGPLVTSKNNIW----WLIGDTS 497

  Fly   330 YGLVCGSQGLPSVYTKVHLYTDWI 353
            :|..|.....|.||..|.::||||
Human   498 WGSGCAKAYRPGVYGNVMVFTDWI 521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3700	NP_611736.1	Tryp_SPc	102..356	CDD:238113	80/269 (30%)
CG3700	NP_611736.1	Tryp_SPc	102..353	CDD:214473	78/267 (29%)
TMPRSS2	NP_001128571.1	DUF3824	<44..91	CDD:289625
		LDLa	150..185	CDD:238060
		SRCR_2	190..283	CDD:292133	10/48 (21%)
		Tryp_SPc	292..521	CDD:214473	79/289 (27%)
		Tryp_SPc	293..524	CDD:238113	80/269 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910