DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3700 and TMPRSS15

DIOPT Version :9

Sequence 1:	NP_611736.1	Gene:	CG3700 / 37640	FlyBaseID:	FBgn0034796	Length:	360	Species:	Drosophila melanogaster
Sequence 2:	XP_011527956.1	Gene:	TMPRSS15 / 5651	HGNCID:	9490	Length:	1064	Species:	Homo sapiens

Alignment Length:	400	Identity:	102/400 - (25%)
Similarity:	169/400 - (42%)	Gaps:	112/400 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 YCDNGTGECKELTPSDCPVIFYN----------------QHLIGAEVKYCDEFNDIVCCPIPLDH 70
            :|::|:.|      :|| |.|:|                .|...|| .:..:.::.||..:.|..
Human   712 HCEDGSDE------ADC-VRFFNGTTNNNGLVRFRIQSIWHTACAE-NWTTQISNDVCQLLGLGS 768

  Fly    71 QN-LKPAEQT--RPFEK---------------QCKQYNEVRSACQS------------TPFIVGG 105
            .| .||...|  .||.|               ||.|.:.:|..|..            ||.||||
Human   769 GNSSKPIFPTDGGPFVKLNTAPDGHLILTPSQQCLQDSLIRLQCNHKSCGKKLAAQDITPKIVGG 833

  Fly   106 TKASGKEFPFMALIGTHRPNKSKSDINWDCGGSVVHPKFVLTAAHCL---ETDESK-----AERL 162
            :.|....:|:  ::|.:...:..      ||.|:|...::::||||:   ..:.||     ...:
Human   834 SNAKEGAWPW--VVGLYYGGRLL------CGASLVSSDWLVSAAHCVYGRNLEPSKWTAILGLHM 890

  Fly   163 DPNFDSPKFVVRLGELDYNSTTDDALVQDFRVVNYVVHPGYDTEDEEQGFKNDIALVELDRKAEF 227
            ..|..||:.|.||                  :...|::|.|:...::    ||||::.|:.|..:
Human   891 KSNLTSPQTVPRL------------------IDEIVINPHYNRRRKD----NDIAMMHLEFKVNY 933

  Fly   228 NDHVAAVCLPPDSGNDV----QQVTAAGWGFTA-DGVKSSHLLKVNLQRFSDEVCQKRL-RFSID 286
            .|::..:|||.:  |.|    :..:.||||... .|..::.|.:.::...|:|.||::: .::|
Human   934 TDYIQPICLPEE--NQVFPPGRNCSIAGWGTVVYQGTTANILQEADVPLLSNERCQQQMPEYNI- 995

  Fly   287 TRTQFCAGSMSSQADTCNGDSGGPIFVQHPLYPCLKQ----VIGIVSYGLVCGSQGLPSVYTKVH 347
            |....|||......|:|.||||||:.       |.:.    :.|:.|:|..|.....|.||.:|.
Human   996 TENMICAGYEEGGIDSCQGDSGGPLM-------CQENNRWFLAGVTSFGYKCALPNRPGVYARVS 1053

  Fly   348 LYTDWIESIV 357
            .:|:||:|.:
Human  1054 RFTEWIQSFL 1063

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3700	NP_611736.1	Tryp_SPc	102..356	CDD:238113	73/271 (27%)
CG3700	NP_611736.1	Tryp_SPc	102..353	CDD:214473	71/268 (26%)
TMPRSS15	XP_011527956.1	SEA	53..195	CDD:214554
		LDLa	229..263	CDD:238060
		CUB	270..376	CDD:278839
		MAM	387..547	CDD:214533
		MAM	392..547	CDD:99706
		CUB	569..676	CDD:278839
		LDLa	688..722	CDD:238060	3/15 (20%)
		SR	723..816	CDD:214555	21/93 (23%)
		Tryp_SPc	829..1059	CDD:214473	71/269 (26%)
		Tryp_SPc	830..1061	CDD:238113	73/270 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910