DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3700 and MASP1

DIOPT Version :9

Sequence 1:	NP_611736.1	Gene:	CG3700 / 37640	FlyBaseID:	FBgn0034796	Length:	360	Species:	Drosophila melanogaster
Sequence 2:	XP_011511291.1	Gene:	MASP1 / 5648	HGNCID:	6901	Length:	735	Species:	Homo sapiens

Alignment Length:	437	Identity:	111/437 - (25%)
Similarity:	156/437 - (35%)	Gaps:	131/437 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 ECKEL--------TPSDCPVIFYNQHLIGAEVKY--------CDEF-----------NDIVCC-- 64
            ||.||        .||.....|.:|.|:..:..|        .|.|           |.|..|
Human   307 ECPELQPPVHGKIEPSQAKYFFKDQVLVSCDTGYKVLKDNVEMDTFQIECLKDGTWSNKIPTCKI 371

  Fly    65 -----PIPLDH--------QNLKPAEQ------TRPFEK-------------------------- 84
                 |..|:|        .||...:.      ..|:.|
Human   372 VDCRAPGELEHGLITFSTRNNLTTYKSEIKYSCQEPYYKMLNNNTGIYTCSAQGVWMNKVLGRSL 436

  Fly    85 -----QCKQYNEVRSACQSTPFIVGGTKASGKEFPFMALIGTHRPNKSKSDINWDCGGSVVHPKF 144
                 :|.|.:  ||.......|:||..|....||:.|||.....::..:| .|...|:::...:
Human   437 PTCLPECGQPS--RSLPSLVKRIIGGRNAEPGLFPWQALIVVEDTSRVPND-KWFGSGALLSASW 498

  Fly   145 VLTAAHCLETDESKAERLDPN---FDSPKFVVRLGELDYNSTTDDALVQDFRVVNYVVHPGYDTE 206
            :|||||.|     :::|.|..   .......|.||   .:...|.:...:......|:||.::.
Human   499 ILTAAHVL-----RSQRRDTTVIPVSKEHVTVYLG---LHDVRDKSGAVNSSAARVVLHPDFNI- 554

  Fly   207 DEEQGFKNDIALVELDRKAEFNDHVAAVCLP---PDSGNDVQQVTAAGWGFTADGVKSSHLLKVN 268
               |.:.:|||||:|........||..||||   |:..........||||.:...|....::...
Human   555 ---QNYNHDIALVQLQEPVPLGPHVMPVCLPRLEPEGPAPHMLGLVAGWGISNPNVTVDEIISSG 616

  Fly   269 LQRFSDEVCQKRL-----------------RFSIDTRTQFCAGSMSSQADTCNGDSGGPIFVQHP 316
            .:..||.:...:|                 .:|: |...||||......|||.||||| .||
Human   617 TRTLSDVLQYVKLPVVPHAECKTSYESRSGNYSV-TENMFCAGYYEGGKDTCLGDSGG-AFV--- 676

  Fly   317 LYPCLKQ---VIGIVSYG--LVCGSQGLPSVYTKVHLYTDWIESIVW 358
            ::..|.|   |.|:||:|  ..|||:.:..|||||..|.||    ||
Human   677 IFDDLSQRWVVQGLVSWGGPEECGSKQVYGVYTKVSNYVDW----VW 719

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3700	NP_611736.1	Tryp_SPc	102..356	CDD:238113	83/281 (30%)
CG3700	NP_611736.1	Tryp_SPc	102..353	CDD:214473	82/278 (29%)
MASP1	XP_011511291.1	CUB	35..144	CDD:238001
		FXa_inhibition	160..188	CDD:291342
		CUB	192..301	CDD:278839
		Sushi	308..369	CDD:278512	13/60 (22%)
		CCP	374..439	CDD:153056	7/64 (11%)
		Tryp_SPc	456..718	CDD:214473	83/283 (29%)
		Tryp_SPc	457..718	CDD:238113	83/282 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910