DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3700 and PROC

DIOPT Version :9

Sequence 1:	NP_611736.1	Gene:	CG3700 / 37640	FlyBaseID:	FBgn0034796	Length:	360	Species:	Drosophila melanogaster
Sequence 2:	XP_024308770.1	Gene:	PROC / 5624	HGNCID:	9451	Length:	576	Species:	Homo sapiens

Alignment Length:	384	Identity:	107/384 - (27%)
Similarity:	161/384 - (41%)	Gaps:	86/384 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 YCDNGTGECKEL--------------TPSDCP-------VIFYNQHL-IGAEVKYCDE---FNDI 61
            :|..|.||...|              |.:.||       |.|.|..| .|....||.|   :...
Human   211 FCQRGEGERWMLAGGGAGLGPGWGRGTSTSCPRPPLPAEVSFLNCSLDNGGCTHYCLEEVGWRRC 275

  Fly    62 VCCP---IPLDHQNLKPAEQ---TRPFEKQCKQYNEVR-----SACQSTPFIVGGTKASGKEFPF 115
            .|.|   :..|.....||.:   .||:::..|:.:.::     ...|..|.::.|......:.|:
Human   276 SCAPGYKLGDDLLQCHPAVKFPCGRPWKRMEKKRSHLKRDTEDQEDQVDPRLIDGKMTRRGDSPW 340

  Fly   116 MALIGTHRPNKSKSDINWDCGGSVVHPKFVLTAAHCLETDESKAERLDPNFDSPKFVVRLGELDY 180
            ..::   ..:|.|    ..||..::||.:|||||||:  ||||           |.:|||||.|.
Human   341 QVVL---LDSKKK----LACGAVLIHPSWVLTAAHCM--DESK-----------KLLVRLGEYDL 385

  Fly   181 NSTTDDALVQDFRVVNYVVHPGYDTEDEEQGFKNDIALVELDRKAEFNDHVAAVCLPPDSG---- 241
            .......|..|.:.|  .|||.|.....:    |||||:.|.:.|..:..:..:|| ||||
Human   386 RRWEKWELDLDIKEV--FVHPNYSKSTTD----NDIALLHLAQPATLSQTIVPICL-PDSGLAER 443

  Fly   242 --NDV-QQVTAAGWGFTADGVKSS--------HLLKVNLQRFSDEVCQKRLRFSIDTRTQFCAGS 295
              |.. |:....|||:.:...|.:        :.:|:.:...::  |.: :..::.:....|||.
Human   444 ELNQAGQETLVTGWGYHSSREKEAKRNRTFVLNFIKIPVVPHNE--CSE-VMSNMVSENMLCAGI 505

  Fly   296 MSSQADTCNGDSGGPIFVQ-HPLYPCLKQVIGIVSYGLVCGSQGLPSVYTKVHLYTDWI 353
            :..:.|.|.||||||:... |..:    .::|:||:|..||......|||||..|.|||
Human   506 LGDRQDACEGDSGGPMVASFHGTW----FLVGLVSWGEGCGLLHNYGVYTKVSRYLDWI 560

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3700	NP_611736.1	Tryp_SPc	102..356	CDD:238113	81/268 (30%)
CG3700	NP_611736.1	Tryp_SPc	102..353	CDD:214473	79/266 (30%)
PROC	XP_024308770.1	GLA	117..168	CDD:214503
		EGF_CA	182..213	CDD:238011	0/1 (0%)
		FXa_inhibition	255..290	CDD:317114	8/34 (24%)
		Tryp_SPc	328..563	CDD:238113	81/267 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910