DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3700 and C1s1

DIOPT Version :9

Sequence 1:	NP_611736.1	Gene:	CG3700 / 37640	FlyBaseID:	FBgn0034796	Length:	360	Species:	Drosophila melanogaster
Sequence 2:	NP_001091086.1	Gene:	C1s1 / 50908	MGIID:	1355312	Length:	694	Species:	Mus musculus

Alignment Length:	325	Identity:	91/325 - (28%)
Similarity:	132/325 - (40%)	Gaps:	82/325 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 IGAEVKYCDEFNDIVCCPIPLDHQNLKPAEQTRPFEKQCKQYNEVRSACQSTPFIVGGTKASGKE 112
            :|.|:..|     |..|.:|           |.||:...:              |.||..|..:.
Mouse   420 LGIELPRC-----IPACGVP-----------TEPFQVHQR--------------IFGGQPAKIEN 454

  Fly   113 FPFMALIGTHRPNKSKSDINWDCGGSVVHPKFVLTAAHCLETDESKAERLDPNFDSPKFVVRLGE 177
            ||:....  :.|..|         |::::..:||||||.||      :..||       ::.:|.
Mouse   455 FPWQVFF--NHPRAS---------GALINEYWVLTAAHVLE------KISDP-------LMYVGT 495

  Fly   178 LDYNST-TDDALVQDFRVVNYVVHPGYDTEDE---EQGFKNDIALVELDRKAEFNDHVAAVCLPP 238
            :...:| .::|  |........:||.:..||:   ...|.||||||:|....:....|:.:|||.
Mouse   496 MSVRTTLLENA--QRLYSKRVFIHPSWKKEDDPNTRTNFDNDIALVQLKDPVKMGPKVSPICLPG 558

  Fly   239 DSG------NDVQQVTAAGWGFTADGVKSSHLLKVNLQRFSDEVCQK--------RLRFSIDTRT 289
            .|.      .|:..:  :|||.|...|...:|....:...|.|.|::        |....:.|..
Mouse   559 TSSEYNVSPGDMGLI--SGWGSTEKKVFVINLRGAKVPVTSLETCKQVKEENPTVRPEDYVFTDN 621

  Fly   290 QFCAGSMSSQADTCNGDSGGPIFVQHPLYPCLK-QVIGIVSYGLVCGSQGLPSVYTKVHLYTDWI 353
            ..|||...  .|:|:|||||....|.|.....| .|.|:||:|..||:.|   |||||..|.|||
Mouse   622 MICAGEKG--VDSCHGDSGGAFAFQVPNVTVPKFYVAGLVSWGKRCGTYG---VYTKVKNYVDWI 681

Fly 354 353
Mouse 682 681

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3700	NP_611736.1	Tryp_SPc	102..356	CDD:238113	82/271 (30%)
CG3700	NP_611736.1	Tryp_SPc	102..353	CDD:214473	80/269 (30%)
C1s1	NP_001091086.1	CUB	24..135	CDD:238001
		FXa_inhibition	149..177	CDD:373209
		CUB	181..293	CDD:366096
		CCP	307..361	CDD:153056
		CCP	365..428	CDD:153056	3/12 (25%)
		Tryp_SPc	443..681	CDD:214473	80/284 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910