DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3700 and KLKB1

DIOPT Version :9

Sequence 1:	NP_611736.1	Gene:	CG3700 / 37640	FlyBaseID:	FBgn0034796	Length:	360	Species:	Drosophila melanogaster
Sequence 2:	XP_011530232.1	Gene:	KLKB1 / 3818	HGNCID:	6371	Length:	649	Species:	Homo sapiens

Alignment Length:	384	Identity:	96/384 - (25%)
Similarity:	151/384 - (39%)	Gaps:	95/384 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 PGIQI------LLLIASVSVVTEYCDNGTGECK----ELTPSDCP------------------VI 41
            ||:..      :..:..|:|..|.|.... .|:    .|.|.||.                  :.
Human   309 PGVDFGGEELNVTFVKGVNVCQETCTKMI-RCQFFTYSLLPEDCKEEKCKCFLRLSMDGSPTRIA 372

  Fly    42 FYNQHLIGAEVKYCDEFNDIVCCPIPLDHQNLKPAEQTRPFEKQCKQYNEVRSACQSTPFIVGGT 106
            :..|...|..::.|:..::.||                               ..:::..|||||
Human   373 YGTQGSSGYSLRLCNTGDNSVC-------------------------------TTKTSTRIVGGT 406

  Fly   107 KASGKEFPFMALIGTHRPNKSKSDINWDCGGSVVHPKFVLTAAHCLETDESKAERLDPNFDSPKF 171
            .:|..|:|:...:......:...     ||||::..::|||||||              ||....
Human   407 NSSWGEWPWQVSLQVKLTAQRHL-----CGGSLIGHQWVLTAAHC--------------FDGLPL 452

  Fly   172 --VVRL--GELDYNSTTDDALVQDFRVVNYVVHPGYDTEDEEQGFKNDIALVELDRKAEFNDHVA 232
              |.|:  |.|:.:..|.|......:.:  ::|..|...:.    .:||||::|.....:.:...
Human   453 QDVWRIYSGILNLSDITKDTPFSQIKEI--IIHQNYKVSEG----NHDIALIKLQAPLNYTEFQK 511

  Fly   233 AVCLPP--DSGNDVQQVTAAGWGFTAD-GVKSSHLLKVNLQRFSDEVCQKRLRFSIDTRTQFCAG 294
            .:|||.  |:..........||||:.: |...:.|.|||:...::|.||||.:....|:...|||
Human   512 PICLPSKGDTSTIYTNCWVTGWGFSKEKGEIQNILQKVNIPLVTNEECQKRYQDYKITQRMVCAG 576

  Fly   295 SMSSQADTCNGDSGGPIFVQHPLYPCLKQVIGIVSYGLVCGSQGLPSVYTKVHLYTDWI 353
            ......|.|.||||||:..:|   ..:.:::||.|:|..|..:..|.|||||..|.|||
Human   577 YKEGGKDACKGDSGGPLVCKH---NGMWRLVGITSWGEGCARREQPGVYTKVAEYMDWI 632

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3700	NP_611736.1	Tryp_SPc	102..356	CDD:238113	80/259 (31%)
CG3700	NP_611736.1	Tryp_SPc	102..353	CDD:214473	78/257 (30%)
KLKB1	XP_011530232.1	APPLE	21..104	CDD:128519
		APPLE	111..194	CDD:128519
		APPLE	212..295	CDD:128519
		APPLE	303..386	CDD:128519	13/77 (17%)
		Tryp_SPc	401..632	CDD:214473	78/258 (30%)
		Tryp_SPc	402..632	CDD:238113	78/257 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910