DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3700 and OVCH2

DIOPT Version :9

Sequence 1:	NP_611736.1	Gene:	CG3700 / 37640	FlyBaseID:	FBgn0034796	Length:	360	Species:	Drosophila melanogaster
Sequence 2:	XP_016873148.1	Gene:	OVCH2 / 341277	HGNCID:	29970	Length:	569	Species:	Homo sapiens

Alignment Length:	321	Identity:	88/321 - (27%)
Similarity:	135/321 - (42%)	Gaps:	73/321 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    74 KPAEQTRPFEKQCKQYNEVRSACQSTPF--------IVGGTKASGKEFPFMALIGTHRPNKSKSD 130
            |.|..:.|....|.|     |..:..|:        |:||::.....:|:...:        |..
Human    25 KSATLSLPKAPSCGQ-----SLVKVQPWNYFNIFSRILGGSQVEKGSYPWQVSL--------KQR 76

  Fly   131 INWDCGGSVVHPKFVLTAAHCLETDESKAERLDPNFDSPKFVVRLGELDYNSTTDDALVQDFRVV 195
            ....||||:|.|::|:|||||: .:.:....|:         |..||.|.:.|  |...|...:.
Human    77 QKHICGGSIVSPQWVITAAHCI-ANRNIVSTLN---------VTAGEYDLSQT--DPGEQTLTIE 129

  Fly   196 NYVVHPGYDTEDEEQGFKNDIALVELDRKAEFNDHVAAVCLPPDSGNDVQQ-------VTAAGWG 253
            ..::||.:.|   ::....||||:::....:|...|..:|||     ::::       .|.||||
Human   130 TVIIHPHFST---KKPMDYDIALLKMAGAFQFGHFVGPICLP-----ELREQFEAGFICTTAGWG 186

  Fly   254 -FTADGVKSSHLLKVNLQRFSDEVCQK---RLRFSIDTRTQFCAGSMSSQADTCNGDSGGPIFVQ 314
             .|..||.|..|.:|||...:.|.|..   .|:..|..:|..|.|......|.|.|||||.:..:
Human   187 RLTEGGVLSQVLQEVNLPILTWEECVAALLTLKRPISGKTFLCTGFPDGGRDACQGDSGGSLMCR 251

  Fly   315 HPLYPCLKQ----VIGIVSYGLVCG----------SQGLPSVYTKVHLYTDWI-ESIVWGN 360
            :      |:    :.|:.|:||.||          .||.|.::|.:.....|| |.|..||
Human   252 N------KKGAWTLAGVTSWGLGCGRGWRNNVRKSDQGSPGIFTDISKVLPWIHEHIQTGN 306

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3700	NP_611736.1	Tryp_SPc	102..356	CDD:238113	78/279 (28%)
CG3700	NP_611736.1	Tryp_SPc	102..353	CDD:214473	75/275 (27%)
OVCH2	XP_016873148.1	Tryp_SPc	55..298	CDD:214473	75/276 (27%)
		Tryp_SPc	56..301	CDD:238113	77/278 (28%)
		CUB	320..424	CDD:238001
		CUB	435..546	CDD:238001
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910