DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3700 and PRSS53

DIOPT Version :9

Sequence 1:	NP_611736.1	Gene:	CG3700 / 37640	FlyBaseID:	FBgn0034796	Length:	360	Species:	Drosophila melanogaster
Sequence 2:	XP_011544118.1	Gene:	PRSS53 / 339105	HGNCID:	34407	Length:	623	Species:	Homo sapiens

Alignment Length:	314	Identity:	72/314 - (22%)
Similarity:	107/314 - (34%)	Gaps:	105/314 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   112 EFPFMALI---GTHRPNKSKSDINWDCGGSVVHPKFVLTAAHCLETDESKAERLDPNFDSPKFVV 173
            |:|:.|.:   |.|           .|.||:|...:|||||||.|    ||...:.|    .:.|
Human    47 EWPWQASVRRQGAH-----------ICSGSLVADTWVLTAAHCFE----KAAATELN----SWSV 92

  Fly   174 RLGELDYNSTTDDALVQDFRVVNYVVHPGYDTEDEEQGFKNDIALVELDRKAEFNDHVAAVCLPP 238
            .||.|.....:..|  ::..|....:...|:  ...||  :|:||::|   |....| ..:|||.
Human    93 VLGSLQREGLSPGA--EEVGVAALQLPRAYN--HYSQG--SDLALLQL---AHPTTH-TPLCLPQ 147

  Fly   239 DS-----GNDVQQVTAAGWG-FTADG-----VKSSHLLKVNLQRFSDEVCQ-------------- 278
            .:     |   ....|.||. .|:||     :|....|.:.....|...|.
Human   148 PAHRFPFG---ASCWATGWDQDTSDGKCWPRLKLGEALCLPSVTVSAPNCPGFQSPLLPRSQTLA 209

  Fly   279 ------------KRLRFSIDTRT---------------------QFCAGSMSSQADTCNGDSGGP 310
                        :.||..:.:|.                     ..|.|........|.||||||
Human   210 PAPSLSPAPGTLRNLRLRLISRPTCNCIYNQLHQRHLSNPARPGMLCGGPQPGVQGPCQGDSGGP 274

  Fly   311 IFVQHPLYPCLKQ-----VIGIVSYGLVCGSQGLPSVYTKVHLYTDWIESIVWG 359
            :.       ||:.     ..||:|:...|..:..|.:.|....::.|:::.|.|
Human   275 VL-------CLEPDGHWVQAGIISFASSCAQEDAPVLLTNTAAHSSWLQARVQG 321

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3700	NP_611736.1	Tryp_SPc	102..356	CDD:238113	70/309 (23%)
CG3700	NP_611736.1	Tryp_SPc	102..353	CDD:214473	69/306 (23%)
PRSS53	XP_011544118.1	Tryp_SPc	42..316	CDD:238113	70/307 (23%)
		Tryp_SPc	43..314	CDD:214473	69/305 (23%)
		Tryp_SPc	359..>512	CDD:304450
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910