DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3700 and plg

DIOPT Version :9

Sequence 1:	NP_611736.1	Gene:	CG3700 / 37640	FlyBaseID:	FBgn0034796	Length:	360	Species:	Drosophila melanogaster
Sequence 2:	NP_958880.2	Gene:	plg / 322691	ZFINID:	ZDB-GENE-030131-1411	Length:	818	Species:	Danio rerio

Alignment Length:	396	Identity:	110/396 - (27%)
Similarity:	161/396 - (40%)	Gaps:	126/396 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 CDNGTG--------------EC---KELTPSDCPVIFYNQHLI---------GAEVKYC----DE 57
            |.||.|              .|   :.:||        :||..         |.|...|    .:
Zfish   491 CKNGNGAEYRGSTSMTVMGVTCQAWRSMTP--------HQHASFTPETHPDKGLESNQCRNPDSD 547

  Fly    58 FNDIVC-----------CPIPLDHQNLK---PAEQTRPFEKQCKQYNEVRSACQSTPF--IVGGT 106
            .|...|           |.|| |.::||   ||  |:|  |:|              |  ||||.
Zfish   548 VNGPWCYTTDPSKKWDYCQIP-DCESLKCGQPA--TKP--KRC--------------FGRIVGGC 593

  Fly   107 KASGKEFPFMALIGTHRPNKSKSDINWDCGGSVVHPKFVLTAAHCLETDESKAERLDPNFDSPK- 170
            .:....:|:...:      :::..|:: |||:::.|::|:|||||||..           |||.
Zfish   594 VSKPHSWPWQISL------RTRGKIHF-CGGTLIDPQWVVTAAHCLERS-----------DSPSA 640

  Fly   171 FVVRLGELDYNSTTDDALVQDFRVVNYVVHPGYDTEDEEQGFKNDIALVELDRKAEFNDHVAAVC 235
            :.:.||  .:.....::..|:..|...:..|.          ..||||::|||.|..||.|:.||
Zfish   641 YKIMLG--IHTERATESSKQERDVTKIIKGPA----------GTDIALLKLDRPALINDKVSPVC 693

  Fly   236 LPPDS----GNDVQQVTAAGWGFTADGVKSSHLLKVNLQRFSDEVCQKRLRFSIDTRT---QFCA 293
            ||...    .|....||  |||.|.|.....:|.:.......::|| .|..| ::.|.   :.||
Zfish   694 LPEKDYIVPSNTECYVT--GWGETQDTGGEGYLKETGFPVIENKVC-NRPSF-LNGRVKDHEMCA 754

  Fly   294 GSMSSQADTCNGDSGGPIFVQHPLYPCLKQ----VIGIVSYGLVCGSQGLPSVYTKVHLYTDWIE 354
            |::....|:|.||||||:.       |..|    :.|:.|:||.|.:...|.|||:|..:.||||
Zfish   755 GNIEGGNDSCQGDSGGPLV-------CYAQNTFVLQGVTSWGLGCANAMKPGVYTRVSKFVDWIE 812

  Fly   355 SIVWGN 360
            ..:..|
Zfish   813 RSIKEN 818

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3700	NP_611736.1	Tryp_SPc	102..356	CDD:238113	82/265 (31%)
CG3700	NP_611736.1	Tryp_SPc	102..353	CDD:214473	79/262 (30%)
plg	NP_958880.2	PAN_AP_HGF	31..104	CDD:238532
		KR	109..190	CDD:214527
		KR	190..270	CDD:214527
		KR	281..361	CDD:214527
		Kringle	376..453	CDD:306546
		KR	490..572	CDD:214527	18/89 (20%)
		Tryp_SPc	589..813	CDD:238113	81/264 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910