DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3700 and HABP2

DIOPT Version :9

Sequence 1:	NP_611736.1	Gene:	CG3700 / 37640	FlyBaseID:	FBgn0034796	Length:	360	Species:	Drosophila melanogaster
Sequence 2:	NP_004123.1	Gene:	HABP2 / 3026	HGNCID:	4798	Length:	560	Species:	Homo sapiens

Alignment Length:	368	Identity:	108/368 - (29%)
Similarity:	166/368 - (45%)	Gaps:	55/368 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LLLIASVSVVTEYCD-NGTGE---CKELTPSDCPVIFYNQHLIGAEVKYCDEFNDIVCCPIPLDH 70
            |||..:.::..|..: :|.||   |:.....:.|..|..  :...:||:  |:.|:..|    ..
Human   222 LLLQENYNMFMEDAETHGIGEHNFCRNPDADEKPWCFIK--VTNDKVKW--EYCDVSAC----SA 278

  Fly    71 QNLKPAEQTRPFEKQCK-----QYNEVRSACQSTPFIVGGTKASGKEFPFMALIGTHRPNKSKSD 130
            |::...|:: |.|...|     ...:...|.:....|.||.|::..:.|:.|.:.:..|......
Human   279 QDVAYPEES-PTEPSTKLPGFDSCGKTEIAERKIKRIYGGFKSTAGKHPWQASLQSSLPLTISMP 342

  Fly   131 INWDCGGSVVHPKFVLTAAHCLETDESKAERLDPNFDSPKFVVRLGELDYNSTTDDALVQDFRVV 195
            ....|||:::||.:|||||||.:.   |...|.         |.||:.|...  ::...|.|||.
Human   343 QGHFCGGALIHPCWVLTAAHCTDI---KTRHLK---------VVLGDQDLKK--EEFHEQSFRVE 393

  Fly   196 NYVVHPGYDTEDEEQGFKNDIALVEL----DRKAEFNDHVAAVCLPPDSGNDVQQVTAAGWGFTA 256
            ....:..|:..||..  .|||||::|    ...|..:.:|..||||..|.....:...:|||.|.
Human   394 KIFKYSHYNERDEIP--HNDIALLKLKPVDGHCALESKYVKTVCLPDGSFPSGSECHISGWGVTE 456

  Fly   257 DGVKSSHLLKVNLQRFSDEVCQKRLRFS--IDTRTQFCAGSMSSQA-DTCNGDSGGPIFVQHPLY 318
            .|..|..||...::..::.:|..|..:.  ||. :..|||::.... |||.||||||:
Human   457 TGKGSRQLLDAKVKLIANTLCNSRQLYDHMIDD-SMICAGNLQKPGQDTCQGDSGGPL------- 513

  Fly   319 PCLKQ----VIGIVSYGLVCGSQGLPSVYTKVHLYTDWIESIV 357
            .|.|.    |.||||:||.||.:  |.|||:|..:.:||::.:
Human   514 TCEKDGTYYVYGIVSWGLECGKR--PGVYTQVTKFLNWIKATI 554

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3700	NP_611736.1	Tryp_SPc	102..356	CDD:238113	87/264 (33%)
CG3700	NP_611736.1	Tryp_SPc	102..353	CDD:214473	85/261 (33%)
HABP2	NP_004123.1	EGF	77..106	CDD:306513
		KR	191..277	CDD:238056	15/62 (24%)
		Tryp_SPc	314..553	CDD:238113	87/264 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910