DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3700 and PAMR1

DIOPT Version :9

Sequence 1:	NP_611736.1	Gene:	CG3700 / 37640	FlyBaseID:	FBgn0034796	Length:	360	Species:	Drosophila melanogaster
Sequence 2:	NP_056245.2	Gene:	PAMR1 / 25891	HGNCID:	24554	Length:	737	Species:	Homo sapiens

Alignment Length:	424	Identity:	99/424 - (23%)
Similarity:	158/424 - (37%)	Gaps:	102/424 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 SVVTEYCDNG-------------TGE-----------CKELTPSDC------------------- 38
            :||:.:|:|.             .||           |:|...||.
Human   326 TVVSFFCNNSYVLSGNEKRTCQQNGEWSGKQPICIKACREPKISDLVRRRVLPMQVQSRETPLHQ 390

  Fly    39 --PVIFYNQHLIGAEVKY-CDEFNDIVCCPIPLDHQNLKPAEQTRPFEKQCKQYNEVRSACQST- 99
              ...|..|.|..|..|. ...|.|     :|:.:|:|....|........::....|..|..|
Human   391 LYSAAFSKQKLQSAPTKKPALPFGD-----LPMGYQHLHTQLQYECISPFYRRLGSSRRTCLRTG 450

  Fly   100 ----------PFI-----VGGTKASGKEFPFMALI-----GTHRPNKSKSDINWDCGGSVVHPKF 144
                      |..     :...|..|..:|:.|.|     |.|..:..|......|.|::|:.:.
Human   451 KWSGRAPSCIPICGKIENITAPKTQGLRWPWQAAIYRRTSGVHDGSLHKGAWFLVCSGALVNERT 515

  Fly   145 VLTAAHCLETDESKAERLDPNFDSPKFVVRLGELDYNSTTDDALVQDFRVVNYVVHPGYDTEDEE 209
            |:.||||: ||..|...:    .:....|.||:...:...|:..:|..::...::||.||....:
Human   516 VVVAAHCV-TDLGKVTMI----KTADLKVVLGKFYRDDDRDEKTIQSLQISAIILHPNYDPILLD 575

  Fly   210 QGFKNDIALVELDRKAEFNDHVAAVCLPP--DSGNDVQQ--VTAAGWGFTAD----GVKSSHLLK 266
            .    |||:::|..||..:..|..:||..  |.....|:  :|.|||...||    |.|:..|..
Human   576 A----DIAILKLLDKARISTRVQPICLAASRDLSTSFQESHITVAGWNVLADVRSPGFKNDTLRS 636

  Fly   267 VNLQRFSDEVCQKR-----LRFSIDTRTQFCAG-SMSSQADTCNGDSGGPIFVQHPLYPCLK--- 322
            ..:......:|:::     :..|: |...|||. ..::.:|.|..::||...|..|.....:
Human   637 GVVSVVDSLLCEEQHEDHGIPVSV-TDNMFCASWEPTAPSDICTAETGGIAAVSFPGRASPEPRW 700

  Fly   323 QVIGIV--SYGLVCGSQGLPSVYTKVHLYTDWIE 354
            .::|:|  ||...| |..|.:.:|||..:.||||
Human   701 HLMGLVSWSYDKTC-SHRLSTAFTKVLPFKDWIE 733

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3700	NP_611736.1	Tryp_SPc	102..356	CDD:238113	74/282 (26%)
CG3700	NP_611736.1	Tryp_SPc	102..353	CDD:214473	71/279 (25%)
PAMR1	NP_056245.2	CUB	128..234	CDD:238001
		EGF_CA	240..272	CDD:238011
		CCP	297..360	CDD:153056	6/33 (18%)
		CCP	<425..460	CDD:153056	4/34 (12%)
		Tryp_SPc	478..735	CDD:238113	72/267 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910