DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3700 and F12

DIOPT Version :9

Sequence 1:	NP_611736.1	Gene:	CG3700 / 37640	FlyBaseID:	FBgn0034796	Length:	360	Species:	Drosophila melanogaster
Sequence 2:	NP_000496.2	Gene:	F12 / 2161	HGNCID:	3530	Length:	615	Species:	Homo sapiens

Alignment Length:	302	Identity:	85/302 - (28%)
Similarity:	127/302 - (42%)	Gaps:	43/302 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 PIPLDHQNLKPAEQTRPFEKQCKQYNEVRSACQSTPFIVGGTKASGKEFPFMALIGTHRPNKSKS 129
            |..|..:..:|...||.....|.|  .:|.:..|...:|||..|.....|::|.
Human   338 PGALPAKREQPPSLTRNGPLSCGQ--RLRKSLSSMTRVVGGLVALRGAHPYIAA----------- 389

  Fly   130 DINWD---CGGSVVHPKFVLTAAHCLETDESKAERLDPNFDSPKFVVRLGELDYNSTTDDALVQD 191
             :.|.   |.||::.|.:||||||||: |....|.|         .|.||:...|.:.:..  |.
Human   390 -LYWGHSFCAGSLIAPCWVLTAAHCLQ-DRPAPEDL---------TVVLGQERRNHSCEPC--QT 441

  Fly   192 FRVVNYVVHPGYDTEDEEQGFKNDIALVELDRKAE-----FNDHVAAVCLPPDSG--NDVQQVTA 249
            ..|.:|.:|..:    ....:::|:||:.|...|:     .:.:|..||||..:.  ::......
Human   442 LAVRSYRLHEAF----SPVSYQHDLALLRLQEDADGSCALLSPYVQPVCLPSGAARPSETTLCQV 502

  Fly   250 AGWGFTADGVK--SSHLLKVNLQRFSDEVCQ-KRLRFSIDTRTQFCAGSMSSQADTCNGDSGGPI 311
            ||||...:|.:  :|.|.:..:...|.|.|. ..:..|.......|||.:....|.|.||||||:
Human   503 AGWGHQFEGAEEYASFLQEAQVPFLSLERCSAPDVHGSSILPGMLCAGFLEGGTDACQGDSGGPL 567

  Fly   312 FVQHPLYPCLKQVIGIVSYGLVCGSQGLPSVYTKVHLYTDWI 353
            ..:.........:.||:|:|..||.:..|.|||.|..|..||
Human   568 VCEDQAAERRLTLQGIISWGSGCGDRNKPGVYTDVAYYLAWI 609

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3700	NP_611736.1	Tryp_SPc	102..356	CDD:238113	76/265 (29%)
CG3700	NP_611736.1	Tryp_SPc	102..353	CDD:214473	74/263 (28%)
F12	NP_000496.2	FN2	41..88	CDD:128373
		EGF_CA	96..131	CDD:238011
		FN1	133..173	CDD:238018
		EGF	178..206	CDD:278437
		Kringle	217..295	CDD:278480
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	298..359		5/20 (25%)
		Tryp_SPc	372..609	CDD:214473	74/264 (28%)
		Tryp_SPc	373..612	CDD:238113	76/265 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910