DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3700 and F10

DIOPT Version :9

Sequence 1:	NP_611736.1	Gene:	CG3700 / 37640	FlyBaseID:	FBgn0034796	Length:	360	Species:	Drosophila melanogaster
Sequence 2:	NP_000495.1	Gene:	F10 / 2159	HGNCID:	3528	Length:	488	Species:	Homo sapiens

Alignment Length:	407	Identity:	102/407 - (25%)
Similarity:	156/407 - (38%)	Gaps:	107/407 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 TEYCDNGTGECKE-LTPSDCPVI---------FYNQHLIGAEVKYCDEF-----NDIVC------ 63
            |..|.| .|:||: |....|..:         .:.:.|...:...||:|     |.:||
Human    92 TSPCQN-QGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGY 155

  Fly    64 --------C----PIPLDHQNLKPAEQT----------RPFEKQCKQYNEVRSACQSTPF----- 101
                    |    |.|...|.|:..:::          .|.....|.|:.........||
Human   156 TLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDF 220

  Fly   102 --------------IVGGTKASGKEFPFMALIGTHRPNKSKSDINWD----CGGSVVHPKFVLTA 148
                          ||||.:....|.|:.||:           ||.:    |||:::...::|||
Human   221 NQTQPERGDNNLTRIVGGQECKDGECPWQALL-----------INEENEGFCGGTILSEFYILTA 274

  Fly   149 AHCLETDESKAERLDPNFDSPKFVVRLGELDYNSTTDDALVQDFRVVNYVVHPGYDTEDEEQGFK 213
            ||||             :.:.:|.||:|:.:.........|.:..||  :.|..:..|.    :.
Human   275 AHCL-------------YQAKRFKVRVGDRNTEQEEGGEAVHEVEVV--IKHNRFTKET----YD 320

  Fly   214 NDIALVELDRKAEFNDHVAAVCLPPDSGNDVQQVT-----AAGWGFTAD-GVKSSHLLKVNLQRF 272
            .|||::.|.....|..:||..|||.....:...:|     .:|:|.|.: |.:|:.|..:.:...
Human   321 FDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYV 385

  Fly   273 SDEVCQKRLRFSIDTRTQFCAGSMSSQADTCNGDSGGPIFVQHPLYPCLKQVIGIVSYGLVCGSQ 337
            ....|:....|.| |:..||||..:.|.|.|.||||||...:   :.....|.||||:|..|..:
Human   386 DRNSCKLSSSFII-TQNMFCAGYDTKQEDACQGDSGGPHVTR---FKDTYFVTGIVSWGEGCARK 446

  Fly   338 GLPSVYTKVHLYTDWIE 354
            |...:||||..:..||:
Human   447 GKYGIYTKVTAFLKWID 463

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3700	NP_611736.1	Tryp_SPc	102..356	CDD:238113	77/263 (29%)
CG3700	NP_611736.1	Tryp_SPc	102..353	CDD:214473	75/260 (29%)
F10	NP_000495.1	GLA	25..85	CDD:214503
		EGF_CA	86..122	CDD:238011	8/30 (27%)
		FXa_inhibition	129..164	CDD:317114	6/34 (18%)
		O-glycosylated at one site	183..203		2/19 (11%)
		Tryp_SPc	235..464	CDD:238113	77/263 (29%)
		O-glycosylated at one site	476..485
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910