DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3700 and F9

DIOPT Version :9

Sequence 1:	NP_611736.1	Gene:	CG3700 / 37640	FlyBaseID:	FBgn0034796	Length:	360	Species:	Drosophila melanogaster
Sequence 2:	NP_000124.1	Gene:	F9 / 2158	HGNCID:	3551	Length:	461	Species:	Homo sapiens

Alignment Length:	384	Identity:	96/384 - (25%)
Similarity:	154/384 - (40%)	Gaps:	82/384 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 CDNGTGECKELTPSD---CPVIFYNQHL---IGAEVK--YCDEF------NDIVC---------- 63
            |.|| |.||:...|.   ||..|..::.   :...:|  .|::|      |.:||
Human   102 CLNG-GSCKDDINSYECWCPFGFEGKNCELDVTCNIKNGRCEQFCKNSADNKVVCSCTEGYRLAE 165

  Fly    64 ----C----PIPLDHQNLKPAEQTRPFEKQCKQYNEVRSA---------CQSTPF------IVGG 105
                |    |.|....::....:....|......:.|.|.         .|||..      :|||
Human   166 NQKSCEPAVPFPCGRVSVSQTSKLTRAETVFPDVDYVNSTEAETILDNITQSTQSFNDFTRVVGG 230

  Fly   106 TKASGKEFPFMALIGTHRPNKSKSDINWDCGGSVVHPKFVLTAAHCLETDESKAERLDPNFDSPK 170
            ..|...:||:..::        ...::..||||:|:.|:::|||||:||             ..|
Human   231 EDAKPGQFPWQVVL--------NGKVDAFCGGSIVNEKWIVTAAHCVET-------------GVK 274

  Fly   171 FVVRLGELDYNSTTDDALVQDFRVVNYVVHPGYDTEDEEQGFKNDIALVELDRKAEFNDHVAAVC 235
            ..|..||  :|....:...|...|:..:.|..|:....:  :.:||||:|||.....|.:|..:|
Human   275 ITVVAGE--HNIEETEHTEQKRNVIRIIPHHNYNAAINK--YNHDIALLELDEPLVLNSYVTPIC 335

  Fly   236 LPPDSGNDV----QQVTAAGWGFTADGVKSSHLLK-VNLQRFSDEVCQKRLRFSIDTRTQFCAGS 295
            :......::    .....:|||......:|:.:|: :.:.......|.:..:|:| ....||||.
Human   336 IADKEYTNIFLKFGSGYVSGWGRVFHKGRSALVLQYLRVPLVDRATCLRSTKFTI-YNNMFCAGF 399

  Fly   296 MSSQADTCNGDSGGPIFVQHPLYPCLKQVIGIVSYGLVCGSQGLPSVYTKVHLYTDWIE 354
            .....|:|.||||||...:   ......:.||:|:|..|..:|...:||||..|.:||:
Human   400 HEGGRDSCQGDSGGPHVTE---VEGTSFLTGIISWGEECAMKGKYGIYTKVSRYVNWIK 455

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3700	NP_611736.1	Tryp_SPc	102..356	CDD:238113	71/258 (28%)
CG3700	NP_611736.1	Tryp_SPc	102..353	CDD:214473	69/255 (27%)
F9	NP_000124.1	GLA	28..92	CDD:214503
		EGF_CA	93..129	CDD:238011	10/27 (37%)
		FXa_inhibition	134..170	CDD:317114	6/35 (17%)
		Tryp_SPc	227..457	CDD:238113	71/258 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910