DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3700 and F2

DIOPT Version :9

Sequence 1:	NP_611736.1	Gene:	CG3700 / 37640	FlyBaseID:	FBgn0034796	Length:	360	Species:	Drosophila melanogaster
Sequence 2:	NP_000497.1	Gene:	F2 / 2147	HGNCID:	3535	Length:	622	Species:	Homo sapiens

Alignment Length:	411	Identity:	103/411 - (25%)
Similarity:	157/411 - (38%)	Gaps:	113/411 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 ASVSVVTEYCDNGTGE----------------------CKELT----------PSDCPV------ 40
            ::|.:|..:|.|..|:                      |:|..          .||..:
Human   253 SAVQLVENFCRNPDGDEEGVWCYVAGKPGDFGYCDLNYCEEAVEEETGDGLDEDSDRAIEGRTAT 317

  Fly    41 ----IFYNQHLIGAEVKYCDEFNDIVCCPIPLDHQNLKPAEQTRPFEKQCKQYNEVRSACQS--T 99
                .|:|....|:....|                .|:|.     |||:..:....|...:|  .
Human   318 SEYQTFFNPRTFGSGEADC----------------GLRPL-----FEKKSLEDKTERELLESYID 361

  Fly   100 PFIVGGTKASGKEFPFMALIGTHRPNKSKSDINWDCGGSVVHPKFVLTAAHCLETDESKAERLDP 164
            ..||.|:.|.....|:..::....|.:..      ||.|::..::||||||||     .....|.
Human   362 GRIVEGSDAEIGMSPWQVMLFRKSPQELL------CGASLISDRWVLTAAHCL-----LYPPWDK 415

  Fly   165 NFDSPKFVVRLGELDYNSTTDDALVQDFRVVNYV-VHPGYDTEDEEQGFKNDIALVELDRKAEFN 228
            ||.....:||:|:  ::.|..:..::...::..: :||.|:.   .:....||||::|.:...|:
Human   416 NFTENDLLVRIGK--HSRTRYERNIEKISMLEKIYIHPRYNW---RENLDRDIALMKLKKPVAFS 475

  Fly   229 DHVAAVCLPPDSGNDVQQVTAA------------GWG-----FTADGVKS--SHLLKVNLQRFSD 274
            |::..||||       .:.|||            |||     :||:..|.  |.|..|||.....
Human   476 DYIHPVCLP-------DRETAASLLQAGYKGRVTGWGNLKETWTANVGKGQPSVLQVVNLPIVER 533

  Fly   275 EVCQKRLRFSIDTRTQFCAG---SMSSQADTCNGDSGGPIFVQHPLYPCLKQVIGIVSYGLVCGS 336
            .||:...|..| |...||||   ....:.|.|.||||||..::.|......| :||||:|..|..
Human   534 PVCKDSTRIRI-TDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQ-MGIVSWGEGCDR 596

  Fly   337 QGLPSVYTKVHLYTDWIESIV 357
            .|....||.|.....||:.::
Human   597 DGKYGFYTHVFRLKKWIQKVI 617

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3700	NP_611736.1	Tryp_SPc	102..356	CDD:238113	83/276 (30%)
CG3700	NP_611736.1	Tryp_SPc	102..353	CDD:214473	81/273 (30%)
F2	NP_000497.1	GLA	25..88	CDD:214503
		KR	105..186	CDD:238056
		KR	211..293	CDD:214527	6/39 (15%)
		Thrombin_light	317..363	CDD:286482	11/66 (17%)
		Tryp_SPc	363..613	CDD:214473	81/274 (30%)
		Tryp_SPc	364..616	CDD:238113	83/276 (30%)
		High affinity receptor-binding region which is also known as the TP508 peptide	551..573		10/21 (48%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910