DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3700 and TMPRSS6

DIOPT Version :9

Sequence 1:	NP_611736.1	Gene:	CG3700 / 37640	FlyBaseID:	FBgn0034796	Length:	360	Species:	Drosophila melanogaster
Sequence 2:	NP_001275929.1	Gene:	TMPRSS6 / 164656	HGNCID:	16517	Length:	824	Species:	Homo sapiens

Alignment Length:	391	Identity:	102/391 - (26%)
Similarity:	156/391 - (39%)	Gaps:	94/391 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 CDNG----------TGECKELTPSDC---PVIFYNQH--LIGAEVKYCDEFNDIVCCPIPLDHQN 72
            |.||          |.:|||  .|.|   |.:...|.  |.|::.:.|.|  .:.|.......::
Human   471 CPNGLDERNCVCRATFQCKE--DSTCISLPKVCDGQPDCLNGSDEEQCQE--GVPCGTFTFQCED 531

  Fly    73 LKPAEQTRPFEKQCKQYNEVRSACQS----------TPFIVGGTKASGKEFPFMALI---GTHRP 124
            ....::..|   ||....:.|.....          :..||||..:|..|:|:.|.:   |.|
Human   532 RSCVKKPNP---QCDGRPDCRDGSDEEHCDCGLQGPSSRIVGGAVSSEGEWPWQASLQVRGRH-- 591

  Fly   125 NKSKSDINWDCGGSVVHPKFVLTAAHCLETDESKAERLDPNFDSPKFVVRLGELDYNSTTDDALV 189
                     .|||:::..::|:|||||.:.|...:..|        :.|.||::..||.....:
Human   592 ---------ICGGALIADRWVITAAHCFQEDSMASTVL--------WTVFLGKVWQNSRWPGEV- 638

  Fly   190 QDFRVVNYVVHPGYDTEDEEQGFKNDIALVELDRKAEFNDHVAAVCLPPDSG--NDVQQVTAAGW 252
             .|:|...::||.:    ||.....|:||::||.....:..|..||||..|.  .........||
Human   639 -SFKVSRLLLHPYH----EEDSHDYDVALLQLDHPVVRSAAVRPVCLPARSHFFEPGLHCWITGW 698

  Fly   253 G------FTADGVK-----------------SSHLLKVNLQRFSDEVCQKRLRFSIDTRTQFCAG 294
            |      ..||.|.                 |:.|.||::|....::|.:..|:.:..| ..|||
Human   699 GALREGALRADAVALFYGWRNQGSETCCCPISNALQKVDVQLIPQDLCSEVYRYQVTPR-MLCAG 762

  Fly   295 SMSSQADTCNGDSGGPIFVQHPLYPCLKQ---VIGIVSYGLVCGSQGLPSVYTKVHLYTDWIESI 356
            ....:.|.|.||||||:..:     .|..   :.|:||:||.||......|||::.....||:.:
Human   763 YRKGKKDACQGDSGGPLVCK-----ALSGRWFLAGLVSWGLGCGRPNYFGVYTRITGVISWIQQV 822

  Fly   357 V 357
            |
Human   823 V 823

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3700	NP_611736.1	Tryp_SPc	102..356	CDD:238113	81/284 (29%)
CG3700	NP_611736.1	Tryp_SPc	102..353	CDD:214473	79/281 (28%)
TMPRSS6	NP_001275929.1	SEA	77..177	CDD:307516
		CUB	326..440	CDD:238001
		LDLa	450..480	CDD:238060	3/8 (38%)
		LDLa	486..516	CDD:238060	9/31 (29%)
		Ldl_recept_a	520..557	CDD:278486	5/39 (13%)
		Tryp_SPc	568..822	CDD:238113	81/284 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910