DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3700 and tmprss6

DIOPT Version :9

Sequence 1:	NP_611736.1	Gene:	CG3700 / 37640	FlyBaseID:	FBgn0034796	Length:	360	Species:	Drosophila melanogaster
Sequence 2:	XP_004913946.2	Gene:	tmprss6 / 100489045	XenbaseID:	XB-GENE-1011573	Length:	806	Species:	Xenopus tropicalis

Alignment Length:	374	Identity:	109/374 - (29%)
Similarity:	159/374 - (42%)	Gaps:	72/374 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 YALPGIQILLLIASVSVVTEYCDNGTGE--CKE---LTPSDCPVIFY---NQHLIGAEVKYCDEF 58
            |..||.:..:.|.||....:.|.|||.|  |.:   ...:.|....|   :...:......||..
Frog   484 YHCPGAESCISITSVCDGKKDCANGTDEELCNQGANFPTAACGAFNYKCADGSCVQKPNAECDSI 548

  Fly    59 NDIVCCPIPLDHQNLKPAEQTRPFEKQCK---QYNEVRSACQSTPFIVGGTKASGKEFPFMALI- 119
            .|   ||...|..|             |.   |...:|        :||||:|...|:|:.|.:
Frog   549 AD---CPDGSDENN-------------CGCGIQAVGIR--------LVGGTQAQEGEWPWQASLQ 589

  Fly   120 --GTHRPNKSKSDINWDCGGSVVHPKFVLTAAHCLETDESKAERLDPNFDSPK-FVVRLGELDYN 181
              |.|           .|||::|..:::||||||. |.||.|        ||: :.|.||::..:
Frog   590 VRGEH-----------ICGGTLVADQWILTAAHCF-TPESYA--------SPEVWTVYLGKVRLS 634

  Fly   182 STTDDALVQDFRVVNYVVHPGYDTEDEEQGFKNDIALVELDRKAEF-NDHVAAVCLPPDSGN--D 243
            .:|...|.  |:|:..|:||.||.:..:.    |:|||.||..... :.||..:|||..:.:  .
Frog   635 RSTQKELA--FKVIRLVIHPFYDEDSHDY----DVALVLLDHLVPLTSPHVQPICLPSSTHHFPT 693

  Fly   244 VQQVTAAGWGFTAD-GVKSSHLLKVNLQRFSDEVCQKRLRFSIDTRTQFCAGSMSSQADTCNGDS 307
            .......|||...: |..|..|.||::|..:.::|.:..|:.|..| ..|||......|.|.|||
Frog   694 GSSCWVTGWGSVKENGPTSDVLQKVDIQLVAQDICTELYRYQISPR-MLCAGYRDGSKDACQGDS 757

  Fly   308 GGPIFVQHPLYPCLKQVIGIVSYGLVCGSQGLPSVYTKVHLYTDWIESI 356
            |.|:..:.......:  .|:||:|..||......||:::.....|||||
Frog   758 GSPLVCKTASGRWFQ--AGLVSWGAGCGIPRYFGVYSRITRLVQWIESI 804

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3700	NP_611736.1	Tryp_SPc	102..356	CDD:238113	83/261 (32%)
CG3700	NP_611736.1	Tryp_SPc	102..353	CDD:214473	80/258 (31%)
tmprss6	XP_004913946.2	SEA	77..176	CDD:396113
		CUB	235..303	CDD:412131
		LDLa	448..478	CDD:238060
		LDLa	480..514	CDD:238060	11/29 (38%)
		LDLa	525..560	CDD:238060	9/50 (18%)
		Tryp_SPc	572..804	CDD:238113	83/260 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910