DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MED23 and MED23

DIOPT Version :9

Sequence 1:	NP_611735.1	Gene:	MED23 / 37639	FlyBaseID:	FBgn0034795	Length:	1439	Species:	Drosophila melanogaster
Sequence 2:	NP_001363446.1	Gene:	MED23 / 9439	HGNCID:	2372	Length:	1374	Species:	Homo sapiens

Alignment Length:	1371	Identity:	659/1371 - (48%)
Similarity:	925/1371 - (67%)	Gaps:	72/1371 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 METQVIDTVNEFLKVDSLDEAFVSVIVFKPNTEQERATRFANDLVTAFGNVAQENREQVLRLYLL 65
            ||||:.....|.:|.:.::|||..:.:..|..|:.:...........:|.::||:.||.::..:.
Human     1 METQLQSIFEEVVKTEVIEEAFPGMFMDTPEDEKTKLISCLGAFRQFWGGLSQESHEQCIQWIVK 65

  Fly    66 RAAGA-SGYHIKVLMAALVKLVDAHVITARMLCDKVLMCEKLDFEHRTFWIESFRLIKRVIVQVD 129
            ...|. |...|..|...|...|:..::..|::|:.::..:.|::|....|..:|:|::::|..||
Human    66 FIHGQHSPKRISFLYDCLAMAVETGLLPPRLVCESLINSDTLEWERTQLWALTFKLVRKIIGGVD 130

  Fly   130 YKGVREIMKVCRDKAQWFPLNVNVTYMPQLLAVEDILRFIFDRNNCLLPAYFIANEIMRPFPY-- 192
            |||||:::||..:|....|..|:...:.||||..:::.:|.:||.|||||||...||.:.:|.
Human   131 YKGVRDLLKVILEKILTIPNTVSSAVVQQLLAAREVIAYILERNACLLPAYFAVTEIRKLYPEGK 195

  Fly   193 --HWKLNRLMTDFVEEFRTTAQMVSIIGHASMLPIVEHFGYADHMMNSWRLDHNTLKFNFKGSLP 255
              ||.|..|::|||:.||.||::.||.|..|:||:|.:.|   .:.|||:||..||:|..||.||
Human   196 LPHWLLGNLVSDFVDTFRPTARINSICGRCSLLPVVNNSG---AICNSWKLDPATLRFPLKGLLP 257

  Fly   256 YEPELLEEQKPLLRYVLEQPYSREMVSQMLNLQK------HQKQRYNALEEQLVNLIVQAMEMTE 314
            |:.:|.|.|..||||||||||||:||..||.|.|      ..|||...||:|||:|:|.|||.:|
Human   258 YDKDLFEPQTALLRYVLEQPYSRDMVCNMLGLNKQTLNIAQHKQRCPVLEDQLVDLVVYAMERSE 322

  Fly   315 ANDATAGSGFNSSDEQITPYEWMWLHLSSQLIYFVLFQFVSFMHIVLALHEKLSKLELRKGRDQL 379
            ..:.....|.:         :.:|.|||||||:||||||.||.|:||:||:||:...|.||||.|
Human   323 TEEKFDDGGTS---------QLLWQHLSSQLIFFVLFQFASFPHMVLSLHQKLAGRGLIKGRDHL 378

  Fly   380 MWILLQFISGSIQKNPITNFLPVFRLFDLLYPELEPLKLPDINKSSMVRHMAPICVWIHLMKKAR 444
            ||:||||||||||||.:.:||||.:||||||||.|.:.:|||||.......|..|:||||.:||:
Human   379 MWVLLQFISGSIQKNALADFLPVMKLFDLLYPEKEYIPVPDINKPQSTHAFAMTCIWIHLNRKAQ 443

  Fly   445 VENMNITRPLPIALKNHYDFLQHLVTANTMMNMTLGNDFRIILICNAYSTNQEYFGRPMGLLLDA 509
            .:|..:..|:|.:|:.|::|||..: .|..:.|   ||::|.|:|||||||.|.|..|||.|::.
Human   444 NDNSKLQIPIPHSLRLHHEFLQQSL-RNKSLQM---NDYKIALLCNAYSTNSECFTLPMGALVET 504

  Fly   510 L--NGTSKSPNGGQIPAVTFSVT-----VLDSLTVHSKMSLIHSFVTQMLKQAQSKGQVP-AAAL 566
            :  ||..:.|..|.....:.|:|     :|||||||:|||||||..|:::|.|.:|..|. |.||
Human   505 IYGNGIMRIPLPGTNCMASGSITPLPMNLLDSLTVHAKMSLIHSIATRVIKLAHAKSSVALAPAL 569

  Fly   567 LETYARLLVYTEIESLGIKGFLSQLMPTVFKNHAWAMLHTLMEMFSYRLHHVPTHYRVQLLSLLH 631
            :|||:|||||.||||||||||:|||:|||||:|||.:||||:||||||:||:..||||||||.||
Human   570 VETYSRLLVYMEIESLGIKGFISQLLPTVFKSHAWGILHTLLEMFSYRMHHIQPHYRVQLLSHLH 634

  Fly   632 SLSSVPQTNKMQLNLCFESTALRLITSIGSAEFQPQFSRYFNDKSPGAVASNESEELNRVLILTL 696
            :|::|.|||:.||:||.|||||||||::||:|.||||:|:.:|  |..|.|.|||||||.|||||
Human   635 TLAAVAQTNQNQLHLCVESTALRLITALGSSEVQPQFTRFLSD--PKTVLSAESEELNRALILTL 697

  Fly   697 ARSMHV---HGGGDEMQG-WCKDFLSNIIQHTPHSWPMHSLACFPPALNEYFTQNNQPPENKQQL 757
            ||:.||   ..|.|.:|| ||||.|..|:..|||:|..|:|:|||..|..:|.|||.|.|::..|
Human   698 ARATHVTDFFTGSDSIQGTWCKDILQTIMSFTPHNWASHTLSCFPGPLQAFFKQNNVPQESRFNL 762

  Fly   758 KKAVEEEYRTWTSMTNENDIIAHFLRPTTNPLFLCLLFKIIWETENISPVAYKILEGISARALST 822
            ||.||||||.|.||:||||||.||....:.|||||||:|::.||::|:.:.|::||.|.||||..
Human   763 KKNVEEEYRKWKSMSNENDIITHFSMQGSPPLFLCLLWKMLLETDHINQIGYRVLERIGARALVA 827

  Fly   823 HLRKFCDYLVAEVASSSDGRDFIHKCVDTINNMIWKFNVVTIDRVVLCLALRTHEGNEAQVCFLI 887
            |:|.|.|:||.|.::|:.|:. ::||::.:|:|:||:|:||:||::||||:|:|||||||||:.|
Human   828 HVRTFADFLVYEFSTSAGGQQ-LNKCIEILNDMVWKYNIVTLDRLILCLAMRSHEGNEAQVCYFI 891

  Fly   888 IQLLLLKASELRNRVQEFCKDNNPDHWKQSNWQDKHLSFHQKYPEKFALDESASQIP-------- 944
            |||||||.::.||||.:|.|:|:|:||.|::|..||:::|:|||||...:..|.|:.
Human   892 IQLLLLKPNDFRNRVSDFVKENSPEHWLQNDWHTKHMNYHKKYPEKLYFEGLAEQVDPPVQIQSP 956

  Fly   945 -LPVYFSNVCLRFLPVLDVVVHRFIELTITNVHQILGFILDHLSILYKFHDRPITYLYNTLHYYE 1008
             ||:||.|||||||||.|:|:|||:||  ..|.:.|..:||||..||||||||:|||||||||||
Human   957 YLPIYFGNVCLRFLPVFDIVIHRFLEL--LPVSKSLETLLDHLGGLYKFHDRPVTYLYNTLHYYE 1019

  Fly  1009 RILRDRPALKKKLVGAITSAFSEIRPPNWSVSEPY-KVYLQS-QDSLWTPELSYYMSLIRRLADT 1071
            ..||||..||:|||.||..:..:.||..|.:|:.| |..:.: :::.|.|:.:||..||.||.||
Human  1020 MHLRDRAFLKRKLVHAIIGSLKDNRPQGWCLSDTYLKCAMNAREENPWVPDDTYYCRLIGRLVDT 1084

  Fly  1072 ISGKN--VFYSTDWRFNEFPNAPTHALYVTCVELLGLPVAPPLVASNLIDVIVSGYAVIPQKDIH 1134
            ::||:  .|.:.|||||||||...|||:||||||:.|.|:...|.:.|::|::....::|:::|.
Human  1085 MAGKSPGPFPNCDWRFNEFPNPAAHALHVTCVELMALAVSGKEVGNALLNVVLKSQPLVPRENIT 1149

  Fly  1135 SYINAVGIVLAALPEPYWSGIYDRLQDMLNTPNMLNWT----YRFNAFELFNFKTVREAMLEKTY 1195
            :::||:|:::.|||||||..::||:..::::|::.:.|    |   .|.||:|....::..|.:.
Human  1150 AWMNAIGLIITALPEPYWIVLHDRIVSVISSPSLTSETEWVGY---PFRLFDFTACHQSYSEMSC 1211

  Fly  1196 AVVLAVAHSVFHHMGAFKLAAMTRYLKEKLKPCVRTEQQLLYLCHVFGPFLQRIELEKPNAVAGI 1260
            :..||:||:|:||....:|:.:.::|.|.|.|.|:||.||||:.|:.||||||.:.|:...:..|
Human  1212 SYTLALAHAVWHHSSIGQLSLIPKFLTEVLLPIVKTEFQLLYVYHLVGPFLQRFQQERTRCMIEI 1276

  Fly  1261 AVLLYEILEIVDK---HHGPKPLQYMDQICDFLYHIKYIHVGNIIKNESEAIIKRLRPLLQMRLR 1322
            .|..|::|..||:   |     |.|||.|||||||:||:..|:.:|.:.|.||..|:|.|::|||
Human  1277 GVAFYDMLLNVDQCSTH-----LNYMDPICDFLYHMKYMFTGDSVKEQVEKIICNLKPALKLRLR 1336

  Fly  1323 FITHLN 1328
            ||||::
Human  1337 FITHIS 1342

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MED23	NP_611735.1	Med23	1..1299	CDD:288430	644/1340 (48%)
MED23	NP_001363446.1	Med23	1..1313	CDD:402944	649/1354 (48%)
MED23	NP_001363446.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1349..1374
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158341
Domainoid	1	1.000	1230	1.000	Domainoid score	I12
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3552
Inparanoid	1	1.050	1265	1.000	Inparanoid score	I171
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45832
OrthoDB	1	1.010	-	-		D57890at33208
OrthoFinder	1	1.000	-	-		FOG0006605
OrthoInspector	1	1.000	-	-		oto91247
orthoMCL	1	0.900	-	-		OOG6_106763
Panther	1	1.100	-	-	LDO	PTHR12691
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2636
SonicParanoid	1	1.000	-	-		X6350
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	14	13.940