Protein Alignment MED23 and MED23

DIOPT Version :10

• Sequence 1: NP_611735.1
• Gene: MED23 / 37639
• FlyBaseID: FBgn0034795
• Length: 1439
• Species: Drosophila melanogaster
• Sequence 2: NP_001363446.1
• Gene: MED23 / 9439
• HGNCID: 2372
• Length: 1374
• Species: Homo sapiens
• Alignment Length: 1371
• Identity: 659/1371 - (48%)
• Similarity: 925/1371 - (67%)
• Gaps: 72/1371 - (5%)

  Fly     1 METQVIDTVNEFLKVDSLDEAFVSVIVFKPNTEQERATRFANDLVTAFGNVAQENREQVLRLYLL 65
            ||||:.....|.:|.:.::|||..:.:..|..|:.:...........:|.::||:.||.::..:.
Human     1 METQLQSIFEEVVKTEVIEEAFPGMFMDTPEDEKTKLISCLGAFRQFWGGLSQESHEQCIQWIVK 65

  Fly    66 RAAGA-SGYHIKVLMAALVKLVDAHVITARMLCDKVLMCEKLDFEHRTFWIESFRLIKRVIVQVD 129
            ...|. |...|..|...|...|:..::..|::|:.::..:.|::|....|..:|:|::::|..||
Human    66 FIHGQHSPKRISFLYDCLAMAVETGLLPPRLVCESLINSDTLEWERTQLWALTFKLVRKIIGGVD 130

  Fly   130 YKGVREIMKVCRDKAQWFPLNVNVTYMPQLLAVEDILRFIFDRNNCLLPAYFIANEIMRPFPY-- 192
            |||||:::||..:|....|..|:...:.||||..:::.:|.:||.|||||||...||.:.:|.
Human   131 YKGVRDLLKVILEKILTIPNTVSSAVVQQLLAAREVIAYILERNACLLPAYFAVTEIRKLYPEGK 195

  Fly   193 --HWKLNRLMTDFVEEFRTTAQMVSIIGHASMLPIVEHFGYADHMMNSWRLDHNTLKFNFKGSLP 255
              ||.|..|::|||:.||.||::.||.|..|:||:|.:.|   .:.|||:||..||:|..||.||
Human   196 LPHWLLGNLVSDFVDTFRPTARINSICGRCSLLPVVNNSG---AICNSWKLDPATLRFPLKGLLP 257

  Fly   256 YEPELLEEQKPLLRYVLEQPYSREMVSQMLNLQK------HQKQRYNALEEQLVNLIVQAMEMTE 314
            |:.:|.|.|..||||||||||||:||..||.|.|      ..|||...||:|||:|:|.|||.:|
Human   258 YDKDLFEPQTALLRYVLEQPYSRDMVCNMLGLNKQTLNIAQHKQRCPVLEDQLVDLVVYAMERSE 322

  Fly   315 ANDATAGSGFNSSDEQITPYEWMWLHLSSQLIYFVLFQFVSFMHIVLALHEKLSKLELRKGRDQL 379
            ..:.....|.:         :.:|.|||||||:||||||.||.|:||:||:||:...|.||||.|
Human   323 TEEKFDDGGTS---------QLLWQHLSSQLIFFVLFQFASFPHMVLSLHQKLAGRGLIKGRDHL 378

  Fly   380 MWILLQFISGSIQKNPITNFLPVFRLFDLLYPELEPLKLPDINKSSMVRHMAPICVWIHLMKKAR 444
            ||:||||||||||||.:.:||||.:||||||||.|.:.:|||||.......|..|:||||.:||:
Human   379 MWVLLQFISGSIQKNALADFLPVMKLFDLLYPEKEYIPVPDINKPQSTHAFAMTCIWIHLNRKAQ 443

  Fly   445 VENMNITRPLPIALKNHYDFLQHLVTANTMMNMTLGNDFRIILICNAYSTNQEYFGRPMGLLLDA 509
            .:|..:..|:|.:|:.|::|||..: .|..:.|   ||::|.|:|||||||.|.|..|||.|::.
Human   444 NDNSKLQIPIPHSLRLHHEFLQQSL-RNKSLQM---NDYKIALLCNAYSTNSECFTLPMGALVET 504

  Fly   510 L--NGTSKSPNGGQIPAVTFSVT-----VLDSLTVHSKMSLIHSFVTQMLKQAQSKGQVP-AAAL 566
            :  ||..:.|..|.....:.|:|     :|||||||:|||||||..|:::|.|.:|..|. |.||
Human   505 IYGNGIMRIPLPGTNCMASGSITPLPMNLLDSLTVHAKMSLIHSIATRVIKLAHAKSSVALAPAL 569

  Fly   567 LETYARLLVYTEIESLGIKGFLSQLMPTVFKNHAWAMLHTLMEMFSYRLHHVPTHYRVQLLSLLH 631
            :|||:|||||.||||||||||:|||:|||||:|||.:||||:||||||:||:..||||||||.||
Human   570 VETYSRLLVYMEIESLGIKGFISQLLPTVFKSHAWGILHTLLEMFSYRMHHIQPHYRVQLLSHLH 634

  Fly   632 SLSSVPQTNKMQLNLCFESTALRLITSIGSAEFQPQFSRYFNDKSPGAVASNESEELNRVLILTL 696
            :|::|.|||:.||:||.|||||||||::||:|.||||:|:.:|  |..|.|.|||||||.|||||
Human   635 TLAAVAQTNQNQLHLCVESTALRLITALGSSEVQPQFTRFLSD--PKTVLSAESEELNRALILTL 697

  Fly   697 ARSMHV---HGGGDEMQG-WCKDFLSNIIQHTPHSWPMHSLACFPPALNEYFTQNNQPPENKQQL 757
            ||:.||   ..|.|.:|| ||||.|..|:..|||:|..|:|:|||..|..:|.|||.|.|::..|
Human   698 ARATHVTDFFTGSDSIQGTWCKDILQTIMSFTPHNWASHTLSCFPGPLQAFFKQNNVPQESRFNL 762

  Fly   758 KKAVEEEYRTWTSMTNENDIIAHFLRPTTNPLFLCLLFKIIWETENISPVAYKILEGISARALST 822
            ||.||||||.|.||:||||||.||....:.|||||||:|::.||::|:.:.|::||.|.||||..
Human   763 KKNVEEEYRKWKSMSNENDIITHFSMQGSPPLFLCLLWKMLLETDHINQIGYRVLERIGARALVA 827

  Fly   823 HLRKFCDYLVAEVASSSDGRDFIHKCVDTINNMIWKFNVVTIDRVVLCLALRTHEGNEAQVCFLI 887
            |:|.|.|:||.|.::|:.|:. ::||::.:|:|:||:|:||:||::||||:|:|||||||||:.|
Human   828 HVRTFADFLVYEFSTSAGGQQ-LNKCIEILNDMVWKYNIVTLDRLILCLAMRSHEGNEAQVCYFI 891

  Fly   888 IQLLLLKASELRNRVQEFCKDNNPDHWKQSNWQDKHLSFHQKYPEKFALDESASQIP-------- 944
            |||||||.::.||||.:|.|:|:|:||.|::|..||:::|:|||||...:..|.|:.
Human   892 IQLLLLKPNDFRNRVSDFVKENSPEHWLQNDWHTKHMNYHKKYPEKLYFEGLAEQVDPPVQIQSP 956

  Fly   945 -LPVYFSNVCLRFLPVLDVVVHRFIELTITNVHQILGFILDHLSILYKFHDRPITYLYNTLHYYE 1008
             ||:||.|||||||||.|:|:|||:||  ..|.:.|..:||||..||||||||:|||||||||||
Human   957 YLPIYFGNVCLRFLPVFDIVIHRFLEL--LPVSKSLETLLDHLGGLYKFHDRPVTYLYNTLHYYE 1019

  Fly  1009 RILRDRPALKKKLVGAITSAFSEIRPPNWSVSEPY-KVYLQS-QDSLWTPELSYYMSLIRRLADT 1071
            ..||||..||:|||.||..:..:.||..|.:|:.| |..:.: :::.|.|:.:||..||.||.||
Human  1020 MHLRDRAFLKRKLVHAIIGSLKDNRPQGWCLSDTYLKCAMNAREENPWVPDDTYYCRLIGRLVDT 1084

  Fly  1072 ISGKN--VFYSTDWRFNEFPNAPTHALYVTCVELLGLPVAPPLVASNLIDVIVSGYAVIPQKDIH 1134
            ::||:  .|.:.|||||||||...|||:||||||:.|.|:...|.:.|::|::....::|:::|.
Human  1085 MAGKSPGPFPNCDWRFNEFPNPAAHALHVTCVELMALAVSGKEVGNALLNVVLKSQPLVPRENIT 1149

  Fly  1135 SYINAVGIVLAALPEPYWSGIYDRLQDMLNTPNMLNWT----YRFNAFELFNFKTVREAMLEKTY 1195
            :::||:|:::.|||||||..::||:..::::|::.:.|    |   .|.||:|....::..|.:.
Human  1150 AWMNAIGLIITALPEPYWIVLHDRIVSVISSPSLTSETEWVGY---PFRLFDFTACHQSYSEMSC 1211

  Fly  1196 AVVLAVAHSVFHHMGAFKLAAMTRYLKEKLKPCVRTEQQLLYLCHVFGPFLQRIELEKPNAVAGI 1260
            :..||:||:|:||....:|:.:.::|.|.|.|.|:||.||||:.|:.||||||.:.|:...:..|
Human  1212 SYTLALAHAVWHHSSIGQLSLIPKFLTEVLLPIVKTEFQLLYVYHLVGPFLQRFQQERTRCMIEI 1276

  Fly  1261 AVLLYEILEIVDK---HHGPKPLQYMDQICDFLYHIKYIHVGNIIKNESEAIIKRLRPLLQMRLR 1322
            .|..|::|..||:   |     |.|||.|||||||:||:..|:.:|.:.|.||..|:|.|::|||
Human  1277 GVAFYDMLLNVDQCSTH-----LNYMDPICDFLYHMKYMFTGDSVKEQVEKIICNLKPALKLRLR 1336

  Fly  1323 FITHLN 1328
            ||||::
Human  1337 FITHIS 1342

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MED23	NP_611735.1	Med23	1..1299	CDD:463299	644/1340 (48%)
MED23	NP_001363446.1	Med23	1..1313	CDD:463299	649/1354 (48%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1349..1374