Protein Alignment MED23 and Med23

DIOPT Version :9

• Sequence 1: NP_611735.1
• Gene: MED23 / 37639
• FlyBaseID: FBgn0034795
• Length: 1439
• Species: Drosophila melanogaster
• Sequence 2: NP_001159888.1
• Gene: Med23 / 70208
• MGIID: 1917458
• Length: 1376
• Species: Mus musculus
• Alignment Length: 1401
• Identity: 666/1401 - (47%)
• Similarity: 928/1401 - (66%)
• Gaps: 81/1401 - (5%)

  Fly     1 METQVIDTVNEFLKVDSLDEAFVSVIVFKPNTEQERATRFANDLVTAFGNVAQENREQVLRLYLL 65
            ||||:.....|.:|.:.::|||..:.:..|..|:.:...........:..::||:.||.::..:.
Mouse     4 METQLQSIFEEVVKTEIIEEAFPGMFMDTPEDEKTKLISCLAAFRQFWSGLSQESHEQCVQWIVK 68

  Fly    66 RAAGA-SGYHIKVLMAALVKLVDAHVITARMLCDKVLMCEKLDFEHRTFWIESFRLIKRVIVQVD 129
            ...|. |...|..|...|...|:..::..||:|:.::..:.|::|....|..:|:|::::|..||
Mouse    69 FIHGQHSPKRISFLYDCLAMAVETGLLPPRMVCESLINSDSLEWERTQLWALTFKLVRKIIGGVD 133

  Fly   130 YKGVREIMKVCRDKAQWFPLNVNVTYMPQLLAVEDILRFIFDRNNCLLPAYFIANEIMRPFPY-- 192
            |||||:::|...:|....|..|:...:.||||..:::.:|.:||.|||||||...||.:.:|.
Mouse   134 YKGVRDLLKAILEKILTIPNTVSSAVVQQLLAAREVIAYILERNACLLPAYFAVTEIRKLYPEGK 198

  Fly   193 --HWKLNRLMTDFVEEFRTTAQMVSIIGHASMLPIVEHFGYADHMMNSWRLDHNTLKFNFKGSLP 255
              ||.|..|::|||:.||.||::.||.|..|:||:|.:.|   .:.|||:||..||:|..||.||
Mouse   199 LPHWLLGNLVSDFVDTFRPTARINSICGRCSLLPVVNNSG---AICNSWKLDPATLRFPLKGLLP 260

  Fly   256 YEPELLEEQKPLLRYVLEQPYSREMVSQMLNLQK------HQKQRYNALEEQLVNLIVQAMEMTE 314
            |:.:|.|.|..||||||||||||:||..||.|.|      ..|||...||:|||:|:|.|||.:|
Mouse   261 YDKDLFEPQTALLRYVLEQPYSRDMVCNMLGLNKQTLNIAQHKQRCPVLEDQLVDLVVYAMERSE 325

  Fly   315 ANDATAGSGFNSSDEQITPYEWMWLHLSSQLIYFVLFQFVSFMHIVLALHEKLSKLELRKGRDQL 379
            ..:.....|.:         :.:|.|||||||:||||||.||.|:||:||:||:...|.||||.|
Mouse   326 TEEKFDDGGTS---------QLLWQHLSSQLIFFVLFQFASFPHMVLSLHQKLAGRGLIKGRDHL 381

  Fly   380 MWILLQFISGSIQKNPITNFLPVFRLFDLLYPELEPLKLPDINKSSMVRHMAPICVWIHLMKKAR 444
            ||:||||||||||||.:.:||||.:||||||||.|.:.:|||||.......|..|:||||.:||:
Mouse   382 MWVLLQFISGSIQKNALADFLPVMKLFDLLYPEKECIPVPDINKPQSTHAFAMTCIWIHLNRKAQ 446

  Fly   445 VENMNITRPLPIALKNHYDFLQHLVTANTMMNMTLG-NDFRIILICNAYSTNQEYFGRPMGLLLD 508
            ..:..:..|:|.:||.|::|||     .::.|.:|. ||::|.|:|||||||.|.|..|||.|::
Mouse   447 NGDSTLQIPIPHSLKLHHEFLQ-----QSLRNKSLQMNDYKIALLCNAYSTNSECFTLPMGALVE 506

  Fly   509 AL--NGTSKSPNGGQIPAVTFSVT-----VLDSLTVHSKMSLIHSFVTQMLKQAQSKGQVP-AAA 565
            .:  ||..:.|..|.....:.|||     :|||||||:|||||||..|:::|.|.:|..|. |.|
Mouse   507 TIYGNGIMRVPLPGTSCLASASVTPLPMNLLDSLTVHAKMSLIHSIATRVIKLAHTKSSVALAPA 571

  Fly   566 LLETYARLLVYTEIESLGIKGFLSQLMPTVFKNHAWAMLHTLMEMFSYRLHHVPTHYRVQLLSLL 630
            |:|||:|||||.||||||||||:|||:|||||:|||.:||||:||||:|:||:..||||||||.|
Mouse   572 LVETYSRLLVYMEIESLGIKGFISQLLPTVFKSHAWGILHTLLEMFSHRMHHIQPHYRVQLLSHL 636

  Fly   631 HSLSSVPQTNKMQLNLCFESTALRLITSIGSAEFQPQFSRYFNDKSPGAVASNESEELNRVLILT 695
            |:|::|.|||:.||:||.|||||||||::||:|.||||:|:.||  |..|.|.|||||||.||||
Mouse   637 HTLAAVAQTNQNQLHLCVESTALRLITALGSSEVQPQFTRFLND--PKTVLSAESEELNRALILT 699

  Fly   696 LARSMHV---HGGGDEMQG-WCKDFLSNIIQHTPHSWPMHSLACFPPALNEYFTQNNQPPENKQQ 756
            |||:.||   ..|.|.:|| ||||.|..|:..|||:|..|:|:|||..|..:|.|||.|.|::..
Mouse   700 LARATHVTDFFTGSDSIQGTWCKDILQTIMNFTPHNWASHTLSCFPAPLQAFFKQNNVPQESRFN 764

  Fly   757 LKKAVEEEYRTWTSMTNENDIIAHFLRPTTNPLFLCLLFKIIWETENISPVAYKILEGISARALS 821
            |||.||||||.|.|||:||:||..|......|||||||:|::.||::||.:.||:||.|.||||.
Mouse   765 LKKNVEEEYRKWKSMTDENEIITQFSVQGFPPLFLCLLWKMLLETDHISQIGYKVLERIGARALV 829

  Fly   822 THLRKFCDYLVAEVASSSDGRDFIHKCVDTINNMIWKFNVVTIDRVVLCLALRTHEGNEAQVCFL 886
            .|:|.|.|:||.|.::|:.|:. ::||::.:|:|:||:|:||:||::||||:|:|||||||||:.
Mouse   830 AHVRTFADFLVYEFSTSAGGQQ-LNKCIEILNDMVWKYNIVTLDRLILCLAMRSHEGNEAQVCYF 893

  Fly   887 IIQLLLLKASELRNRVQEFCKDNNPDHWKQSNWQDKHLSFHQKYPEKFALDESASQIP------- 944
            ||||||||.::.||||.:|.|:|:|:||.||:|..||:|:|:|||||...:..|.|:.
Mouse   894 IIQLLLLKPNDFRNRVSDFVKENSPEHWLQSDWHTKHMSYHKKYPEKLYFEGLAEQVDPPVPIQS 958

  Fly   945 --LPVYFSNVCLRFLPVLDVVVHRFIELTITNVHQILGFILDHLSILYKFHDRPITYLYNTLHYY 1007
              ||:||.|||||||||.|:|:|||:||  ..|.:.|..:||||..||||||||:||||||||||
Mouse   959 PYLPIYFGNVCLRFLPVFDIVIHRFLEL--LPVSKSLETLLDHLGGLYKFHDRPVTYLYNTLHYY 1021

  Fly  1008 ERILRDRPALKKKLVGAITSAFSEIRPPNWSVSEPYKVYLQS--QDSLWTPELSYYMSLIRRLAD 1070
            |..||:|..||:|||.||..:..:.||..|.:|:.|..:..:  :|:.|.||.|||..||.||.|
Mouse  1022 EMCLRNRDHLKRKLVHAIIGSLKDNRPQGWCLSDTYLKHAMNAREDNPWVPEDSYYCKLIGRLVD 1086

  Fly  1071 TISGKN--VFYSTDWRFNEFPNAPTHALYVTCVELLGLPVAPPLVASNLIDVIVSGYAVIPQKDI 1133
            |::||:  .|.:.|||||||||...|||:||||||:.|.|....|.:.|::|::....::|:::|
Mouse  1087 TMAGKSPGPFPNCDWRFNEFPNPAAHALHVTCVELMALAVPGKDVGNALLNVVLKSQPLVPRENI 1151

  Fly  1134 HSYINAVGIVLAALPEPYWSGIYDRLQDMLNTPNMLNWT----YRFNAFELFNFKTVREAMLEKT 1194
            .:::||:|:::.|||||||..::||:.:::::.::.:.|    |   .|.||:|....::..|.:
Mouse  1152 TAWMNAIGLIITALPEPYWIVLHDRIVNVISSSSLTSETEWVGY---PFRLFDFTACHQSYSEMS 1213

  Fly  1195 YAVVLAVAHSVFHHMGAFKLAAMTRYLKEKLKPCVRTEQQLLYLCHVFGPFLQRIELEKPNAVAG 1259
            .:..||:||:|:||....:|:.:.::|.|.|.|.|:||.||||:.|:.||||||.:.|:...:..
Mouse  1214 CSYTLALAHAVWHHSSIGQLSLIPKFLTEALLPVVKTEFQLLYVYHLVGPFLQRFQQERTRCMIE 1278

  Fly  1260 IAVLLYEILEIVDK---HHGPKPLQYMDQICDFLYHIKYIHVGNIIKNESEAIIKRLRPLLQMRL 1321
            |.|..|::|..||:   |     |.|||.|||||||:||:..|:.:|.:.|.||..|:|.|::||
Mouse  1279 IGVAFYDMLLNVDQCSTH-----LNYMDPICDFLYHMKYMFTGDSVKEQVEKIICNLKPALKLRL 1338

  Fly  1322 RFITHLNLEDIHTEKINDNTSNNAITSQTQSPMQTQ 1357
            |||||::       |:.......|:.|.:.:|...|
Mouse  1339 RFITHIS-------KMEPAVPPQALNSGSPAPQSNQ 1367

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MED23	NP_611735.1	Med23	1..1299	CDD:288430	646/1341 (48%)
Med23	NP_001159888.1	Med23	4..1316	CDD:288430	646/1341 (48%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167848737
Domainoid	1	1.000	1229	1.000	Domainoid score	I12
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3552
Inparanoid	1	1.050	1263	1.000	Inparanoid score	I171
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45832
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006605
OrthoInspector	1	1.000	-	-		oto94828
orthoMCL	1	0.900	-	-		OOG6_106763
Panther	1	1.100	-	-	LDO	PTHR12691
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2636
SonicParanoid	1	1.000	-	-		X6350
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.930