DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MED23 and med23

DIOPT Version :9

Sequence 1:	NP_611735.1	Gene:	MED23 / 37639	FlyBaseID:	FBgn0034795	Length:	1439	Species:	Drosophila melanogaster
Sequence 2:	XP_021324080.1	Gene:	med23 / 445483	ZFINID:	ZDB-GENE-040724-82	Length:	1387	Species:	Danio rerio

Alignment Length:	1380	Identity:	672/1380 - (48%)
Similarity:	930/1380 - (67%)	Gaps:	73/1380 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 KVDSLDEAFVSVIVFKPNTEQERATRFANDLVTAFGNVAQENREQVLRLYLLRAAGASGYH---- 74
            |.:.::|||..:.:..|..|:.:.|.........:..:.||:.||.:: :::|.  ..|.|
Zfish    25 KTEVIEEAFAGMFMDSPEDEKTKLTSCLGAFRQFWSTLPQESHEQCVQ-WIVRF--IHGQHSPKR 86

  Fly    75 IKVLMAALVKLVDAHVITARMLCDKVLMCEKLDFEHRTFWIESFRLIKRVIVQVDYKGVREIMKV 139
            |..|...|...|:..::..||:|..::..:.|::|....|..:|:||:::|..|||||||:::|.
Zfish    87 IAFLYDCLAMAVETSLLPPRMVCQALISSDSLEWERTQLWALTFKLIRKIIGGVDYKGVRDLLKA 151

  Fly   140 CRDKAQWFPLNVNVTYMPQLLAVEDILRFIFDRNNCLLPAYFIANEIMRPFP----YHWKLNRLM 200
            ..||.|..|..|:...:.||||..:::.:|.|||.|||||||...||.:..|    .||.|..|:
Zfish   152 VLDKIQTIPNFVSSAVVQQLLAAREVVEYILDRNACLLPAYFAVTEIRKLCPEGALSHWLLGSLI 216

  Fly   201 TDFVEEFRTTAQMVSIIGHASMLPIVEHFGYADHMMNSWRLDHNTLKFNFKGSLPYEPELLEEQK 265
            :|||:.||.||::.||.|..|:||:|.:.|   .:.|||:||..||:|..:|.|||:.:|.:.|.
Zfish   217 SDFVDSFRPTARINSICGRCSLLPVVNNSG---AICNSWKLDPTTLRFPLRGMLPYDKDLFDPQT 278

  Fly   266 PLLRYVLEQPYSREMVSQMLNLQKHQKQRYNALEEQLVNLIVQAMEMTEANDATAGSGFNSSDEQ 330
            .||||||||||||:||..||.|.|..|||...||:|||:|:|.|||.:|..:.....|.:
Zfish   279 GLLRYVLEQPYSRDMVCNMLGLNKQHKQRCPVLEDQLVDLVVYAMERSETEEQFDDGGTS----- 338

  Fly   331 ITPYEWMWLHLSSQLIYFVLFQFVSFMHIVLALHEKLSKLELRKGRDQLMWILLQFISGSIQKNP 395
                :.:|.|||||||:||||||.||.|:||:||:||:...|.||||.|||:||||||||||||.
Zfish   339 ----QLLWQHLSSQLIFFVLFQFASFPHMVLSLHQKLAGRGLIKGRDHLMWVLLQFISGSIQKNA 399

  Fly   396 ITNFLPVFRLFDLLYPELEPLKLPDINKSSMVRHMAPICVWIHLMKKARVENMNITRPLPIALKN 460
            :.:||||.:||||||||.|.:.:|||||.......|..|:||||.:||:.:|..:..|:|.:||.
Zfish   400 LGDFLPVMKLFDLLYPEKECIPVPDINKPQSTHAFAMTCIWIHLNRKAQNDNSKLQIPIPHSLKL 464

  Fly   461 HYDFLQHLVTANTMMNMTLGNDFRIILICNAYSTNQEYFGRPMGLLLD----------ALNGTSK 515
            |::|||..: .|..:.||   |::|.|:|||||||.|.|..|||:|::          .|.||:.
Zfish   465 HHEFLQQSL-RNKSLPMT---DYKIALLCNAYSTNSECFTLPMGVLVETIYGNGSMRITLPGTNC 525

  Fly   516 SPNGGQIPAVTFSVTVLDSLTVHSKMSLIHSFVTQMLKQAQSKGQVP-AAALLETYARLLVYTEI 579
            ..:|...|   ..:.:|||||||:|||||||..|:::|.|.:|..:. |.||:|||:|||||.||
Zfish   526 MASGSVTP---LPMNLLDSLTVHAKMSLIHSIATRVIKLAHAKSSLALAPALVETYSRLLVYMEI 587

  Fly   580 ESLGIKGFLSQLMPTVFKNHAWAMLHTLMEMFSYRLHHVPTHYRVQLLSLLHSLSSVPQTNKMQL 644
            ||||||||:|||:|.|||:|||.:||||:||||||:||:..||||||||.||||::|||||:.||
Zfish   588 ESLGIKGFISQLLPNVFKSHAWGILHTLLEMFSYRMHHIQPHYRVQLLSHLHSLAAVPQTNQNQL 652

  Fly   645 NLCFESTALRLITSIGSAEFQPQFSRYFNDKSPGAVASNESEELNRVLILTLARSMHV---HGGG 706
            :||.|||||||||::||:|.||||:|:.||  |..|.|.|||||||.|||||||:.||   ..|.
Zfish   653 HLCVESTALRLITALGSSEVQPQFTRFLND--PKTVLSAESEELNRALILTLARATHVTDFFTGS 715

  Fly   707 DEMQG-WCKDFLSNIIQHTPHSWPMHSLACFPPALNEYFTQNNQPPENKQQLKKAVEEEYRTWTS 770
            |.:|| ||||.|..|:..|||:|..|:|:|||..|..:|.|||.|.|::..|||.||||||.|.|
Zfish   716 DSIQGTWCKDILQTIMNFTPHNWASHTLSCFPAPLQAFFKQNNVPQESRFNLKKNVEEEYRKWKS 780

  Fly   771 MTNENDIIAHFLRPTTNPLFLCLLFKIIWETENISPVAYKILEGISARALSTHLRKFCDYLVAEV 835
            ||||||||.||....:.|||||||:|::.||::|:.:.:::||.|.||||..|:|.|.|:||.|.
Zfish   781 MTNENDIITHFSMQGSPPLFLCLLWKMLLETDHINQIGFRVLERIGARALVAHVRTFADFLVYEF 845

  Fly   836 ASSSDGRDFIHKCVDTINNMIWKFNVVTIDRVVLCLALRTHEGNEAQVCFLIIQLLLLKASELRN 900
            ::|:.|:. ::||::.:|:|:||:|:||:||::||||:|:|||||||||:.||||||||.::.||
Zfish   846 STSAGGQQ-LNKCIEILNDMVWKYNIVTLDRLILCLAMRSHEGNEAQVCYFIIQLLLLKPNDFRN 909

  Fly   901 RVQEFCKDNNPDHWKQSNWQDKHLSFHQKYPEKFALDESASQIP---------LPVYFSNVCLRF 956
            ||.:|.|:|.|:||.||:|..||:::|:|||||...:..|.|:.         ||:||.||||||
Zfish   910 RVSDFVKENAPEHWLQSDWHTKHMTYHKKYPEKLYFEGLAEQVNPPIQLQSQYLPIYFGNVCLRF 974

  Fly   957 LPVLDVVVHRFIELTITNVHQILGFILDHLSILYKFHDRPITYLYNTLHYYERILRDRPALKKKL 1021
            |||.|:|:|||:||  ..|.:.|..:||||..||||||||:||||||||||||.||||..||:||
Zfish   975 LPVFDIVIHRFLEL--LPVSKSLETLLDHLGGLYKFHDRPVTYLYNTLHYYERHLRDRTNLKRKL 1037

  Fly  1022 VGAITSAFSEIRPPNWSVSEPY-KVYLQS-QDSLWTPELSYYMSLIRRLADTISGKN--VFYSTD 1082
            |.||.|:..:.|.|.|.:||.| |..:.: :|::|.|:.:||..||.||.||::||:  .|.:.|
Zfish  1038 VHAIMSSLKDNRTPGWCLSETYLKCGMNAREDNVWIPDDTYYCKLIGRLVDTMAGKSPGPFPNCD 1102

  Fly  1083 WRFNEFPNAPTHALYVTCVELLGLPVAPPLVASNLIDVIVSGYAVIPQKDIHSYINAVGIVLAAL 1147
            ||||||||...|||:||||||:.|.|....|.:.|::|::....::|:::|.:::||:|:|:.||
Zfish  1103 WRFNEFPNPAAHALHVTCVELMALAVPGKDVGNALLNVVLKSQPLVPRENITAWMNAIGLVITAL 1167

  Fly  1148 PEPYWSGIYDRLQDMLNTPNM---LNWT-YRFNAFELFNFKTVREAMLEKTYAVVLAVAHSVFHH 1208
            |||||..::||:..::::..:   .:|. |   .|:|.:|....::..|...:.|||:||:|:||
Zfish  1168 PEPYWIVLHDRIVSVISSAVLSSGSDWLGY---PFQLLDFTACHQSYSEMHCSYVLALAHAVWHH 1229

  Fly  1209 MGAFKLAAMTRYLKEKLKPCVRTEQQLLYLCHVFGPFLQRIELEKPNAVAGIAVLLYEILEIVDK 1273
            ....:|:.:.::|.|.|||.|:||.||||:.|:.||||||.:.|:...:..|.|..||:|:.||:
Zfish  1230 SSIGQLSLIPKFLSEVLKPIVKTEFQLLYVYHLVGPFLQRFQQERTRCMLEIGVAFYEMLQAVDQ 1294

  Fly  1274 HHGPKPLQYMDQICDFLYHIKYIHVGNIIKNESEAIIKRLRPLLQMRLRFITHLNLEDIHTEKIN 1338
            |  ...|.|||.||||||||||:..|:.:|::.|.||..|||.:::|||||||::..:.....::
Zfish  1295 H--SNHLAYMDPICDFLYHIKYMFTGDSVKDQVERIICSLRPAMRLRLRFITHISKMEPAAVPVS 1357

  Fly  1339 DNTSNNAITSQTQSP 1353
             |:|:...||...||
Zfish  1358 -NSSSVQQTSSASSP 1371

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MED23	NP_611735.1	Med23	1..1299	CDD:288430	651/1324 (49%)
med23	XP_021324080.1	Med23	25..1318	CDD:314461	651/1324 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170594257
Domainoid	1	1.000	1245	1.000	Domainoid score	I11
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3552
Inparanoid	1	1.050	1283	1.000	Inparanoid score	I160
OMA	1	1.010	-	-		QHG45832
OrthoDB	1	1.010	-	-		D57890at33208
OrthoFinder	1	1.000	-	-		FOG0006605
OrthoInspector	1	1.000	-	-		oto41310
orthoMCL	1	0.900	-	-		OOG6_106763
Panther	1	1.100	-	-	LDO	PTHR12691
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2636
SonicParanoid	1	1.000	-	-		X6350
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	14	13.940