DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MED23 and Med23

DIOPT Version :9

Sequence 1:	NP_611735.1	Gene:	MED23 / 37639	FlyBaseID:	FBgn0034795	Length:	1439	Species:	Drosophila melanogaster
Sequence 2:	XP_008756834.1	Gene:	Med23 / 309565	RGDID:	1307671	Length:	1376	Species:	Rattus norvegicus

Alignment Length:	1401	Identity:	668/1401 - (47%)
Similarity:	930/1401 - (66%)	Gaps:	81/1401 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 METQVIDTVNEFLKVDSLDEAFVSVIVFKPNTEQERATRFANDLVTAFGNVAQENREQVLRLYLL 65
            ||||:.....|.:|.:.::|||..:.:..|..|:.:...........:..::||:.||.::..:.
  Rat     4 METQLQSIFEEVVKTEIIEEAFPGMFMDTPEDEKTKLISCLAAFRQFWNGLSQESHEQCVQWIVK 68

  Fly    66 RAAGA-SGYHIKVLMAALVKLVDAHVITARMLCDKVLMCEKLDFEHRTFWIESFRLIKRVIVQVD 129
            ...|. |...|..|...|...|:..::..||:|:.::..:.|::|....|..:|:|::::|..||
  Rat    69 FIHGQHSPKRISFLYDCLAMAVETGLLPPRMVCESLINSDTLEWERTQLWALTFKLVRKIIGGVD 133

  Fly   130 YKGVREIMKVCRDKAQWFPLNVNVTYMPQLLAVEDILRFIFDRNNCLLPAYFIANEIMRPFPY-- 192
            |||||:::||..:|....|..|:...:.||||..:::.:|.:||.|||||||...||.:.:|.
  Rat   134 YKGVRDLLKVILEKILTIPNTVSSAVVQQLLAAREVIAYILERNACLLPAYFAVTEIRKLYPEGK 198

  Fly   193 --HWKLNRLMTDFVEEFRTTAQMVSIIGHASMLPIVEHFGYADHMMNSWRLDHNTLKFNFKGSLP 255
              ||.|..|::|||:.||.||::.||.|..|:||:|.:.|   .:.|||:||..||:|..||.||
  Rat   199 LPHWLLGNLVSDFVDTFRPTARINSICGRCSLLPVVNNSG---AICNSWKLDPATLRFPLKGLLP 260

  Fly   256 YEPELLEEQKPLLRYVLEQPYSREMVSQMLNLQK------HQKQRYNALEEQLVNLIVQAMEMTE 314
            |:.:|.|.|..||||||||||||:||..||.|.|      ..|||...||:|||:|:|.|||.:|
  Rat   261 YDKDLFEPQTALLRYVLEQPYSRDMVCNMLGLNKQTLNIAQHKQRCPVLEDQLVDLVVYAMERSE 325

  Fly   315 ANDATAGSGFNSSDEQITPYEWMWLHLSSQLIYFVLFQFVSFMHIVLALHEKLSKLELRKGRDQL 379
            ..:.....|.:         :.:|.|||||||:||||||.||.|:||:||:||:...|.||||.|
  Rat   326 TEEKFDDGGTS---------QLLWQHLSSQLIFFVLFQFASFPHMVLSLHQKLAGRGLIKGRDHL 381

  Fly   380 MWILLQFISGSIQKNPITNFLPVFRLFDLLYPELEPLKLPDINKSSMVRHMAPICVWIHLMKKAR 444
            ||:||||||||||||.:.:||||.:||||||||.|.:.:|||||.......|..|:||||.:||:
  Rat   382 MWVLLQFISGSIQKNALADFLPVMKLFDLLYPEKECIPVPDINKPQSTHAFAMTCIWIHLNRKAQ 446

  Fly   445 VENMNITRPLPIALKNHYDFLQHLVTANTMMNMTLG-NDFRIILICNAYSTNQEYFGRPMGLLLD 508
            .:|..:..|:|.:||.|::|||     .::.|.:|. ||::|.|:|||||||.|.|..|||.|::
  Rat   447 NDNSKLQIPIPHSLKLHHEFLQ-----QSLRNKSLQMNDYKIALLCNAYSTNSECFTLPMGALVE 506

  Fly   509 AL--NGTSKSPNGGQIPAVTFSVT-----VLDSLTVHSKMSLIHSFVTQMLKQAQSKGQVP-AAA 565
            .:  ||..:.|..|.....:.|||     :|||||||:|||||||..|:::|.|.:|..|. |.|
  Rat   507 TIYGNGIMRVPLPGTSCLASASVTPLPMNLLDSLTVHAKMSLIHSIATRVIKLAHTKSSVALAPA 571

  Fly   566 LLETYARLLVYTEIESLGIKGFLSQLMPTVFKNHAWAMLHTLMEMFSYRLHHVPTHYRVQLLSLL 630
            |:|||:|||||.||||||||||:|||:|||||:|||.:||||:||||:|:||:..||||||||.|
  Rat   572 LVETYSRLLVYMEIESLGIKGFISQLLPTVFKSHAWGILHTLLEMFSHRMHHIQPHYRVQLLSHL 636

  Fly   631 HSLSSVPQTNKMQLNLCFESTALRLITSIGSAEFQPQFSRYFNDKSPGAVASNESEELNRVLILT 695
            |:|::|.|||:.||:||.|||||||||::||:|.||||:|:.||  |..|.|.|||||||.||||
  Rat   637 HTLAAVAQTNQNQLHLCVESTALRLITALGSSEVQPQFTRFLND--PKTVLSAESEELNRALILT 699

  Fly   696 LARSMHV---HGGGDEMQG-WCKDFLSNIIQHTPHSWPMHSLACFPPALNEYFTQNNQPPENKQQ 756
            |||:.||   ..|.|.:|| ||||.|..|:..|||:|..|:|:|||..|..:|.|||.|.|::..
  Rat   700 LARATHVTDFFTGSDSIQGTWCKDILQTIMTFTPHNWASHTLSCFPAPLQAFFKQNNVPQESRFN 764

  Fly   757 LKKAVEEEYRTWTSMTNENDIIAHFLRPTTNPLFLCLLFKIIWETENISPVAYKILEGISARALS 821
            |||.||||||.|.|||:||:||..|......|||||||:|::.||::||.:.||:||.|.||||.
  Rat   765 LKKNVEEEYRKWKSMTDENEIITQFSMQGFPPLFLCLLWKMLLETDHISQIGYKVLERIGARALV 829

  Fly   822 THLRKFCDYLVAEVASSSDGRDFIHKCVDTINNMIWKFNVVTIDRVVLCLALRTHEGNEAQVCFL 886
            .|:|.|.|:||.|.::|:.|:. ::||::.:|:|:||:|:||:||::||||:|:|||||||||:.
  Rat   830 AHVRTFADFLVYEFSTSAGGQQ-LNKCIEILNDMVWKYNIVTLDRLILCLAMRSHEGNEAQVCYF 893

  Fly   887 IIQLLLLKASELRNRVQEFCKDNNPDHWKQSNWQDKHLSFHQKYPEKFALDESASQIP------- 944
            ||||||||.::.||||.:|.|:|:|:||.||:|..||:|:|:|||||...:..|.|:.
  Rat   894 IIQLLLLKPNDFRNRVSDFVKENSPEHWLQSDWHTKHMSYHKKYPEKLYFEGLAEQVDPPVPIQS 958

  Fly   945 --LPVYFSNVCLRFLPVLDVVVHRFIELTITNVHQILGFILDHLSILYKFHDRPITYLYNTLHYY 1007
              ||:||.|||||||||.|:|:|||:||  ..|.:.|..:||||..||||||||:||||||||||
  Rat   959 PYLPIYFGNVCLRFLPVFDIVIHRFLEL--LPVSKSLETLLDHLGGLYKFHDRPVTYLYNTLHYY 1021

  Fly  1008 ERILRDRPALKKKLVGAITSAFSEIRPPNWSVSEPYKVYLQS--QDSLWTPELSYYMSLIRRLAD 1070
            |..||:|..||:|||.||..:..:.||..|.:|:.|..:..:  :|:.|.||.|||..||.||.|
  Rat  1022 EMCLRNRDHLKRKLVHAIIGSLKDNRPQGWCLSDTYLKHAMNAREDNPWVPEDSYYCKLIGRLVD 1086

  Fly  1071 TISGKN--VFYSTDWRFNEFPNAPTHALYVTCVELLGLPVAPPLVASNLIDVIVSGYAVIPQKDI 1133
            |::||:  .|.:.|||||||||...|||:||||||:.|.|....|.:.|::|::....::|:::|
  Rat  1087 TMAGKSPGPFPNCDWRFNEFPNPAAHALHVTCVELMALAVPGKDVGNALLNVVLKSQPLVPRENI 1151

  Fly  1134 HSYINAVGIVLAALPEPYWSGIYDRLQDMLNTPNMLNWT----YRFNAFELFNFKTVREAMLEKT 1194
            .:::||:|:::.|||||||..::||:..::::.::.:.|    |   .|.||:|....::..|.:
  Rat  1152 TAWMNAIGLIITALPEPYWIVLHDRIVSVISSSSLTSETEWVGY---PFRLFDFTACHQSYSEMS 1213

  Fly  1195 YAVVLAVAHSVFHHMGAFKLAAMTRYLKEKLKPCVRTEQQLLYLCHVFGPFLQRIELEKPNAVAG 1259
            .:..||:||:|:||....:|:.:.::|.|.|.|.|:||.||||:.|:.||||||.:.|:...:..
  Rat  1214 CSYTLALAHAVWHHSSIGQLSLIPKFLTEVLLPVVKTEFQLLYVYHLVGPFLQRFQQERTRCMIE 1278

  Fly  1260 IAVLLYEILEIVDK---HHGPKPLQYMDQICDFLYHIKYIHVGNIIKNESEAIIKRLRPLLQMRL 1321
            |.|..|::|..||:   |     |.|||.|||||||:||:..|:.:|.:.|.||..|:|.|::||
  Rat  1279 IGVAFYDMLLNVDQCSTH-----LNYMDPICDFLYHMKYMFTGDSVKEQVEKIICNLKPALKLRL 1338

  Fly  1322 RFITHLNLEDIHTEKINDNTSNNAITSQTQSPMQTQ 1357
            |||||::       |:.......|::|.:.:|...|
  Rat  1339 RFITHIS-------KMEPAVPPQALSSGSPAPQANQ 1367

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MED23	NP_611735.1	Med23	1..1299	CDD:288430	648/1341 (48%)
Med23	XP_008756834.1	Med23	4..1316	CDD:288430	648/1341 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166352325
Domainoid	1	1.000	1202	1.000	Domainoid score	I11
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3552
Inparanoid	1	1.050	1266	1.000	Inparanoid score	I156
OMA	1	1.010	-	-		QHG45832
OrthoDB	1	1.010	-	-		D57890at33208
OrthoFinder	1	1.000	-	-		FOG0006605
OrthoInspector	1	1.000	-	-		oto98334
orthoMCL	1	0.900	-	-		OOG6_106763
Panther	1	1.100	-	-	LDO	PTHR12691
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X6350
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.910