DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MED23 and sur-2

DIOPT Version :9

Sequence 1:	NP_611735.1	Gene:	MED23 / 37639	FlyBaseID:	FBgn0034795	Length:	1439	Species:	Drosophila melanogaster
Sequence 2:	NP_001021463.1	Gene:	sur-2 / 173345	WormBaseID:	WBGene00006349	Length:	1589	Species:	Caenorhabditis elegans

Alignment Length:	1681	Identity:	351/1681 - (20%)
Similarity:	640/1681 - (38%)	Gaps:	422/1681 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 DEAFVSVIVFK---PNTEQERATRFANDLVTAFGNVAQENR----------EQVLRLYLLRAAGA 70
            ||..:..|.|.   ...|::.......:|:....:||::|.          |:|:. .|||.|..
Worm    55 DETAILRIQFNNMMSKMEEKEKQSLVKELIKMVHHVAEKNSPDRVFVGTNYERVVD-QLLRYAHQ 118

  Fly    71 SGYHIKVLMAALVKLVDAHVITARM-LCDKVLMCEKLDFEHRTFWIESFRLIKRVIVQVDYKGVR 134
            .|.....|.|      :..::|:.. ||.::  |:           |.::.|...|.::||||:|
Worm   119 KGAISTNLCA------EGLIMTSDFRLCSRI--CQ-----------EKWKFINDCIPKIDYKGIR 164

  Fly   135 EIMK-VCRDKAQWFPLNVNVTYMPQLLAVEDILRFIFDRNNCLLPAYFIANEIMRPFPYHW---- 194
            .|:: :...:.:..|.:::...:.::..||:::..|.||::.|:|.....:||||..|...
Worm   165 NILRYILESQLRRLPYSLSPEQVNEIRIVENVILHIVDRDSNLMPPLITLSEIMRGMPKQALMLP 229

  Fly   195 KLNRLMTDFVEEFRTTAQMVSIIGHASMLPIVEHFGY-------ADHMMNSWRL---DHNTLKFN 249
            :|...:......||..|.:..:.|...:.||..|..:       .:|.:|:...   .|:|
Worm   230 RLTEKLASLSVHFRPIADLSHVCGRGFVYPIPLHPSFYPLTSCWEEHGLNASNTIVQPHHT---- 290

  Fly   250 FKGSLPYEPELLEEQKPLLRYVLEQPYSREMVSQMLNLQKHQKQRYNALEEQLVN-LIVQAMEMT 313
                |||.||........|..:|.||..::      :|....|.:.....|.|:: :|.::|...
Worm   291 ----LPYRPEHTSTYLYTLYMILRQPLGKD------SLHPPSKTKTKTNWEMLISVMICESMAEA 345

  Fly   314 EANDATAGSGFNSSDEQITPYEWMWLHLSSQLIYFVLFQFVSFMHIVL------ALHEKLSKLEL 372
            |:...|         |.|..|:|      ..::..|::...  .|:::      .|...:.:.:.
Worm   346 ESLPET---------EPIPRYQW------DNIVNIVIYGIT--QHLLVPKTFFNVLKNLIKRCKY 393

  Fly   373 RKGRDQLMWILLQFISGSIQK-----NPITNFLPVF-RLFDLLYPELEPLKLPDI-------NKS 424
            .:.||::|||:.|.: ||:..     :.:|..:.:: .|||           .|:       :.:
Worm   394 TRARDEVMWIVFQVV-GSLSNLTRLDDAVTEIVELYNELFD-----------GDVVWMGASDHPA 446

  Fly   425 SMVRHMAPICVWIHLMKKARVENMNITRPLPIALKNHYDFLQHLV----TANTMMNMTLGNDF-- 483
            ...|.:|....|: :::|...:.|   .|....:|:|..|:|..|    ::||.|...|.|.|
Worm   447 LFARFLAAAGTWM-ILEKDFADKM---PPANETIKSHIKFIQDGVDNFDSSNTAMLAVLSNIFLD 507

  Fly   484 -------RIILICNAYSTNQEYFGRPMGLLLDALNGT-SKSPNGGQIPAV----TFSVTVLDSLT 536
                   ::|:     .|.|:        :|::::.| |......:..||    .|.|..:::||
Worm   508 RTDTKMGKLIV-----PTLQQ--------MLESIDDTKSLFELSYKRMAVNCFSAFPVEFMEALT 559

  Fly   537 VHSKMSL-------IHSFVTQMLKQAQSKGQVPAAALLETYARL-------LVYTEIESLGIKG- 586
            ..||.:|       :.||.|..|         |:.|:.||.|::       :...::|.|..:.
Worm   560 FRSKKTLLIQCFQPLRSFSTVRL---------PSPAVFETVAKICESEDYEMAVKDMEHLAQRSL 615

  Fly   587 ---------------------------FLSQLMPTVFKNHAWAMLHTLMEMFSYRLHHVPTH--- 621
                                       ||...:|.:   ||::...:.:...||...|:|.:
Worm   616 HVATAADRSSGEHQNVQAKDQCYFLFDFLVYRLPHL---HAYSKYSSTVNALSYFTQHIPNNPQN 677

  Fly   622 ---YRVQLLSLL--------------HS--LSSVPQTNKMQLNLCFESTALRLITSIGSAEFQPQ 667
               ||:....|:              |:  ..:..:.|.|..::.:..|
Worm   678 HQIYRLMEQFLMRRWCWAGFHGCITAHTQMFGTSYKDNTMMRHMAYPKT---------------- 726

  Fly   668 FSRYFNDKSPGAVASNESEELNRVLILTLARSMHVHGGGDEMQGWCKDFLSNIIQHTPHSWPMHS 732
            ||  ..|:.|.|:    :.|:.::.|.:..|::.:......::   |.....||  ....||..|
Worm   727 FS--VPDQYPFAI----NPEIFKMAIYSFLRAVKITAQDIAIE---KTMFPTII--NGFGWPEKS 780

  Fly   733 LACFPP-ALNEYFTQNNQPPENKQQLKKAVEEEYRTWTSMTNENDIIAH--FLRPTTNPLFLCLL 794
            .:.||. ||:.....:.....|.:::...|....|..||:|....:|.:  ...|.|:...|.:|
Worm   781 TSYFPKWALDAIKASDTSNAVNTEEILSDVRNTARMHTSLTPNQFVIRYGEDRDPATSHCMLAVL 845

  Fly   795 FKIIW----ETENISPVAYKILEGISARALSTHLRKFCDYLVAEVASSSDGRDFIHKCVDTINNM 855
            |...:    .|.||:...|:::|..:.:.:........||::|:..:.................:
Worm   846 FHFAYNSVDSTYNITSEFYEVMEKKTPKEIVVMGNYLVDYIIADAKTQDCNEKTFKNIAKAAALL 910

  Fly   856 IWKFNVVTIDRVVLCLALRTHEGNEAQVCFLIIQLLLLKASELRNRVQEFCKDNNP--DHWKQSN 918
            :::|.|:..||::|.|.:......:|.:|..|....:| ..|.:.|::.: ..|.|  ||: .:.
Worm   911 VFQFQVLRADRLLLSLIMHPATDEDALICIQIANEFIL-TPEFQERIRWY-HQNVPKKDHF-PTE 972

  Fly   919 WQDKHLSFHQKYPEKFALD-----ESASQIPLPVYFSNVCLRFLPVLDVVVHRFIELTITNVHQI 978
            :....:.:|..:||..|.:     :|:|.:.:|.|:..:..|.||::|..:|..:|   ...:::
Worm   973 YIKAIVKYHDAFPEFEACELVRSYDSSSNVHMPTYYGCLIERLLPIMDQYLHVALE---QQGYKL 1034

  Fly   979 LGFILDHLSILYKFHDRPITYLYNTLHYYERILRDRPALKKKLVGAITSAFSEIRPPNWSVSEPY 1043
            ...||..:|:|||||..||.::|:.|.....::....|  |..|.|..:...|..     ::|.:
Worm  1035 NPQILQSVSMLYKFHAMPIHFMYSVLFTSHGLMSGPDA--KSFVLAFATQIEECH-----LTEAF 1092

  Fly  1044 KVYLQSQDSLWTPELSYYMSLIRRLA---DTISGKNVFYSTDWRFNEF-PNAPTHALYVTCVELL 1104
            :.:...:.|    .....|.||.|::   |.|.....|.:.||:..|. |.|.|  ||:.|:||:
Worm  1093 EKFNHQKSS----REQLIMELIDRMSASLDFILTPPPFVAKDWKIAELSPGAQT--LYLACIELM 1151

  Fly  1105 GLPVAPPLVASNLIDVIVSGYAVIPQKDIHSYINAVGIVLAALPEPYWSGIYDRLQDML---NTP 1166
            ..|.:|..:.:.:|:|:    .:.|.....:.:|...::|.|||..|.:.::|....:.   .|.
Worm  1152 ASPHSPETLVAAMINVM----QMKPHARPFNIVNLTALLLTALPAAYSNALHDEFVAVFVNGETA 1212

  Fly  1167 NMLNWTYRFNAFELFNFKTVREAM---LEKTYAVVLAVAHSVFHHMGAFKLAAMTRYLKEKLKPC 1228
            |:        .||...|....|::   |......:..::...:.|.....|...:.....::...
Worm  1213 NL--------KFEEIVFDNYEESLLLNLPNRARTINVISQQYWLHCSLSLLNFFSHEYVPRILEH 1269

  Fly  1229 VRTEQQLLYLCHVFGPFLQR----------IELEKPN-AVAGIAVLLYEIL--------EIVDKH 1274
            |:||:.|.|...:..|:|:|          :..::.| ....|..|:::.|        |||.:.
Worm  1270 VKTEKDLWYTLRLVMPYLRRYYENWDTAKQMRSQRENFGPLHIVKLVFQKLGSMAEEGVEIVYEQ 1334

  Fly  1275 HGPKPLQYMDQICDFLYHIKYIHVGNIIKNESEAIIKRLRPLLQMRLRFITHLN----------- 1328
            |          :||..|:.||...|:.::|.:.....:|...::.||:|....:
Worm  1335 H----------LCDLFYNCKYFFAGDFLRNTAITEFAKLPEKMRDRLKFYVSQSEPTAEQETPPE 1389

  Fly  1329 -----------LEDIHTEKINDNTSNNAITS-------QTQSPMQTQHQQQ--PQQ--------- 1364
                       .::.|.:......|..:::|       ..|:|:...||..  |||
Worm  1390 KEKSPEKEKEQEQEQHVKAHQPLESTPSVSSLPQMQHHLQQAPLLPSHQMMPPPQQHSSSLQHHL 1454

  Fly  1365 -------------PHQQQQQQQQQQQQQQQQQQ-----QQQQMQQQQINAV------QTTSVPL- 1404
                         .||..|||.....|||.|.|     ..|||..|...||      ....||:
Worm  1455 QHHTSTHQMMDTSQHQTIQQQSNHPTQQQLQHQIPNMSMHQQMGPQYPGAVFHHPSGPVGHVPMQ 1519

  Fly  1405 -GSGGNLQQ---------------------QQQINQQQQMYMQHMQQH-QHMQNMR 1437
             |.|.::||                     |....|||.:|||.:||| ||.|.|:
Worm  1520 YGMGHHMQQHPHLPHHQQMPAPMHTMNPMMQNMTPQQQYLYMQQLQQHQQHQQYMQ 1575

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MED23	NP_611735.1	Med23	1..1299	CDD:288430	299/1453 (21%)
sur-2	NP_001021463.1	Med23	25..1349	CDD:288430	299/1453 (21%)
sur-2	NP_001021463.1	CITED	1409..>1548	CDD:282356	31/138 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160166021
Domainoid	1	1.000	176	1.000	Domainoid score	I2164
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3552
Inparanoid	1	1.050	201	1.000	Inparanoid score	I2464
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45832
OrthoDB	1	1.010	-	-		D57890at33208
OrthoFinder	1	1.000	-	-		FOG0006605
OrthoInspector	1	1.000	-	-		oto17571
orthoMCL	1	0.900	-	-		OOG6_106763
Panther	1	1.100	-	-	LDO	PTHR12691
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2636
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.940