Protein Alignment MED23 and med23

DIOPT Version :9

• Sequence 1: NP_611735.1
• Gene: MED23 / 37639
• FlyBaseID: FBgn0034795
• Length: 1439
• Species: Drosophila melanogaster
• Sequence 2: XP_002936353.2
• Gene: med23 / 100496574
• XenbaseID: XB-GENE-1003994
• Length: 1375
• Species: Xenopus tropicalis
• Alignment Length: 1380
• Identity: 668/1380 - (48%)
• Similarity: 927/1380 - (67%)
• Gaps: 86/1380 - (6%)

  Fly     1 METQVIDTVNEFLKVDSLDEAFVSVIVFKPNTEQERATRFANDLVTAFGN-------VAQENREQ 58
            ||:|::....|.:|.:.::|||..:.:..|..|:.:       |::..|.       :.||:.||
 Frog     1 MESQLLSIFEEMVKTEIIEEAFAGMFMDTPEDERTK-------LISCLGAFRQYWSVLPQESHEQ 58

  Fly    59 VLRLYLLRAAGA-SGYHIKVLMAALVKLVDAHVITARMLCDKVLMCEKLDFEHRTFWIESFRLIK 122
            .::..:....|. |...|..|...|...|:..::..||:|:.::..:.|::|....||.:|:||:
 Frog    59 CVQWIVKFIHGQHSPKRISFLYDCLAMAVETGLLPPRMVCESLINSDSLEWERTQLWILTFKLIR 123

  Fly   123 RVIVQVDYKGVREIMKVCRDKAQWFPLNVNVTYMPQLLAVEDILRFIFDRNNCLLPAYFIANEIM 187
            ::|..|||||||:::||..:|.|..|..|:...:.||||..:::.:|.:||.||||||....|::
 Frog   124 KIIGGVDYKGVRDLLKVILEKIQTVPDTVSSAVVQQLLAAREVVAYILERNACLLPAYLAVTEVL 188

  Fly   188 RPFPY----HWKLNRLMTDFVEEFRTTAQMVSIIGHASMLPIVEHFGYADHMMNSWRLDHNTLKF 248
            :.:|.    ||.|..|::|||:.||.||::.||.|..|:||:|.:.|   .:.|||:||..||:|
 Frog   189 KLYPEGKLPHWLLGDLVSDFVDSFRPTARISSICGRCSLLPVVNNSG---AICNSWKLDPLTLRF 250

  Fly   249 NFKGSLPYEPELLEEQKPLLRYVLEQPYSREMVSQMLNLQK------HQKQRYNALEEQLVNLIV 307
            ..||.|||:.:|.|.|..||||||||||||:||..||.|.|      ..|||...||:|||:|:|
 Frog   251 PLKGLLPYDKDLFEPQTALLRYVLEQPYSRDMVCNMLGLNKQTLNIAQHKQRCPVLEDQLVDLVV 315

  Fly   308 QAMEMTEANDATAGSGFNSSDEQITPYEWMWLHLSSQLIYFVLFQFVSFMHIVLALHEKLSKLEL 372
            .|||.:|..:.....|.:         :.:|.|||||||:||||||.||.|:||:||:||:...|
 Frog   316 YAMERSETEEKFDDGGTS---------QLLWQHLSSQLIFFVLFQFASFPHMVLSLHQKLAGRGL 371

  Fly   373 RKGRDQLMWILLQFISGSIQKNPITNFLPVFRLFDLLYPELEPLKLPDINKSSMVRHMAPICVWI 437
            .||||.|||:||||||||||||.:.:||||.:||||||||.|.:.:|||.|.......|..|:||
 Frog   372 IKGRDHLMWVLLQFISGSIQKNALADFLPVMKLFDLLYPEKECIPVPDITKPQSTHSFAMTCIWI 436

  Fly   438 HLMKKARVENMNITRPLPIALKNHYDFLQHLVTANTMMNMTLGNDFRIILICNAYSTNQEYFGRP 502
            ||.:||:.:|..:..|:|.:||.|::|||..: .|..:.||   |::|.|:|||||||.|.|..|
 Frog   437 HLNRKAQNDNSKLQIPIPHSLKLHHEFLQQSL-RNKSLQMT---DYKIALLCNAYSTNSECFTLP 497

  Fly   503 MGLLLDAL--NGTSKSPNGGQIPAVTFSVT-----VLDSLTVHSKMSLIHSFVTQMLKQAQSKGQ 560
            ||:|::.:  ||....|..|.....:.|:|     :|||||||:|||||||..|:::|.||:|..
 Frog   498 MGVLVETIYGNGNVNIPLPGSNCMASGSITPLPMNLLDSLTVHAKMSLIHSIATRVIKMAQAKST 562

  Fly   561 VP-AAALLETYARLLVYTEIESLGIKGFLSQLMPTVFKNHAWAMLHTLMEMFSYRLHHVPTHYRV 624
            .. |.||:|||:|||||.||||||||||:|||:|||||:|||.:||||:||||||:||:..||||
 Frog   563 FALAPALVETYSRLLVYMEIESLGIKGFISQLLPTVFKSHAWGILHTLLEMFSYRMHHIQPHYRV 627

  Fly   625 QLLSLLHSLSSVPQTNKMQLNLCFESTALRLITSIGSAEFQPQFSRYFNDKSPGAVASNESEELN 689
            ||||.||||:.|||||:.||:||.|||||||||::||:|.||||:|:.:|  |..|.|.||||||
 Frog   628 QLLSHLHSLAGVPQTNQNQLHLCVESTALRLITALGSSEVQPQFTRFLSD--PKTVLSAESEELN 690

  Fly   690 RVLILTLARSMHV---HGGGDEMQG-WCKDFLSNIIQHTPHSWPMHSLACFPPALNEYFTQNNQP 750
            |.||||:||:.||   ..|.:.:|| ||||.|..||..|||:|.:|:|:|||..|..:|.|||.|
 Frog   691 RALILTIARATHVTDFFTGSESIQGTWCKDILQTIISFTPHNWALHTLSCFPAPLQAFFKQNNVP 755

  Fly   751 PENKQQLKKAVEEEYRTWTSMTNENDIIAHFLRPTTNPLFLCLLFKIIWETENISPVAYKILEGI 815
            .|::..|||.||||||.|.|||||||||.||....:.|||||||:|::.||:.|:.:.|::||.|
 Frog   756 QESRFNLKKNVEEEYRKWKSMTNENDIITHFSLQGSPPLFLCLLWKMLLETDQINQIGYRVLERI 820

  Fly   816 SARALSTHLRKFCDYLVAEVASSSDGRDFIHKCVDTINNMIWKFNVVTIDRVVLCLALRTHEGNE 880
            .||||..|:|.|.|:||.|.::|:.|:. ::||::.:|:|:||:|:||:||::||||:|:|||||
 Frog   821 GARALVAHVRTFADFLVYEFSTSAGGQQ-LNKCIEMLNDMVWKYNIVTLDRLILCLAMRSHEGNE 884

  Fly   881 AQVCFLIIQLLLLKASELRNRVQEFCKDNNPDHWKQSNWQDKHLSFHQKYPEKFALDESASQIP- 944
            ||||:.||||||||.::.||||.:|.|:|:|:||.|::|..||:::|:|||||...:..|.|:.
 Frog   885 AQVCYFIIQLLLLKPNDFRNRVSDFVKENSPEHWLQNDWHTKHMNYHKKYPEKLYFEGLAEQVNP 949

  Fly   945 --------LPVYFSNVCLRFLPVLDVVVHRFIELTITNVHQILGFILDHLSILYKFHDRPITYLY 1001
                    ||:||.|||||||||.|:|:|||:||  ..|.:.|..:||||..||||||||:||||
 Frog   950 PVQIQPQYLPIYFGNVCLRFLPVFDIVIHRFLEL--LPVSKSLETLLDHLGGLYKFHDRPVTYLY 1012

  Fly  1002 NTLHYYERILRDRPALKKKLVGAITSAFSEIRPPNWSVSEPYKVYLQS--QDSLWTPELSYYMSL 1064
            |||||||..||||..||:|||.||..:..:.||..|.:|:.|..:..:  .|:.|.|:.:||..|
 Frog  1013 NTLHYYEMQLRDRTNLKRKLVHAIIGSLKDNRPQGWCLSDTYLKFGMNPRDDNPWIPDDTYYCKL 1077

  Fly  1065 IRRLADTISGKN--VFYSTDWRFNEFPNAPTHALYVTCVELLGLPVAPPLVASNLIDVIVSGYAV 1127
            |.||.||::||:  .|.:.|||||||||...|||:||||||:.|.|....|.:.|::|::....:
 Frog  1078 IGRLVDTMAGKSPGPFPNCDWRFNEFPNPAAHALHVTCVELMALAVPGKEVGNALLNVVLKSQPL 1142

  Fly  1128 IPQKDIHSYINAVGIVLAALPEPYWSGIYDRLQDMLNTPNMLNWT----YRFNAFELFNFKTVRE 1188
            :|:::|.:::||:|:::.|||||||..::||:..:||:|::.:.|    |   .|:||:|....:
 Frog  1143 VPRENITAWMNAIGLIITALPEPYWIVLHDRIVSILNSPSLTSETEWVGY---PFQLFDFTACHK 1204

  Fly  1189 AMLEKTYAVVLAVAHSVFHHMGAFKLAAMTRYLKEKLKPCVRTEQQLLYLCHVFGPFLQRIELEK 1253
            |..|.:.:..||:||:|:||....:|:.:.::|.|.|.|.|:||.||||:.|:.||||||.:.|:
 Frog  1205 AYSEMSCSYTLALAHAVWHHSSIGQLSLIPKFLPEVLMPIVKTEYQLLYVYHLVGPFLQRFQQER 1269

  Fly  1254 PNAVAGIAVLLYEILEIVDK---HHGPKPLQYMDQICDFLYHIKYIHVGNIIKNESEAIIKRLRP 1315
            ...:..|.|..||:|..||:   |     |.:||.|||||||:||:..|:.||::.|.||..|||
 Frog  1270 TRCMIEIGVAFYEMLLNVDQCSAH-----LNFMDPICDFLYHMKYMFTGDSIKDQVEKIICNLRP 1329

  Fly  1316 LLQMRLRFITHLNLE 1330
            .|::|||.|||::.|
 Frog  1330 ALKLRLRHITHISTE 1344

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MED23	NP_611735.1	Med23	1..1299	CDD:288430	651/1347 (48%)
med23	XP_002936353.2	Med23	1..1313	CDD:371610	651/1347 (48%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	1207	1.000	Domainoid score	I12
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3552
Inparanoid	1	1.050	1268	1.000	Inparanoid score	I170
OMA	1	1.010	-	-		QHG45832
OrthoDB	1	1.010	-	-		D57890at33208
OrthoFinder	1	1.000	-	-		FOG0006605
OrthoInspector	1	1.000	-	-		oto105024
Panther	1	1.100	-	-	LDO	PTHR12691
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2636
SonicParanoid	1	1.000	-	-		X6350
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	13.110