DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gmer and gfus.1

DIOPT Version :9

Sequence 1:	NP_611734.1	Gene:	Gmer / 37638	FlyBaseID:	FBgn0267823	Length:	321	Species:	Drosophila melanogaster
Sequence 2:	NP_001008620.1	Gene:	gfus.1 / 494077	ZFINID:	ZDB-GENE-040722-1	Length:	318	Species:	Danio rerio

Alignment Length:	320	Identity:	191/320 - (59%)
Similarity:	242/320 - (75%)	Gaps:	8/320 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 KVLVTGGTGLVGKALEAVIKE-QSPEDEQWFFAGSKDADLTNLAATQALFAREKPTHVIHLAAMV 66
            :||||||:||||:|:|.|:|| :..|.|:|.|..||||:|.:...|:|:|.:.:|||||||||||
Zfish     6 RVLVTGGSGLVGRAIERVVKEGEGREGEEWIFLSSKDANLLSPEETKAVFEKHRPTHVIHLAAMV 70

  Fly    67 GGLFHNMNNNLDFLRNNLLINDNVLQTAHEQGCVKVVSCLSTCIFPDKTSYPIDETMVHNGPPHP 131
            ||||.||..||||.|:|:.|||||||.||:.|.||||||||||||||||:|||||||:||||||.
Zfish    71 GGLFRNMRQNLDFWRSNVFINDNVLQAAHDSGVVKVVSCLSTCIFPDKTTYPIDETMIHNGPPHE 135

  Fly   132 SNYGYSYAKRLIDVQNHAYHDKYGRVYTSVIPCNIFGPHDNYNPEVSHVIPGMIYRMHQLVTEKT 196
            ||:||:||||:|||||.|:..::.|.||:|||.|:||.|||:|.|..||:||:|::.:  :.:|.
Zfish   136 SNFGYAYAKRMIDVQNRAFFQQFNRRYTAVIPTNVFGCHDNFNIEDGHVLPGLIHKTY--IAKKE 198

  Fly   197 DVPENDKVFTVFGSGMPLRQFVYSRDLAELMIWVLRNYESVEPIILSADEVQEVTIFEVAQAVAK 261
            ..|     ..|:|||.|||||:||.|||.|.:||||.|:.|||||||..|..|::|.:.|.||.:
Zfish   199 GKP-----LVVWGSGRPLRQFIYSLDLARLFVWVLREYDEVEPIILSVGEEDELSIKDAADAVVE 258

  Fly   262 AFNFNGRLVCDTSKSDGQYKKTASNAKLRSFLPDYAFTDLETAINASVKWYIENYDQARK 321
            |..|.|.::.||||:|||:||||||||||.:|||:.||....||..:..|::.|||.|||
Zfish   259 ALEFTGDVIYDTSKADGQFKKTASNAKLRKYLPDFKFTPFREAIKETCDWFVANYDTARK 318

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gmer	NP_611734.1	GDP_FS_SDR_e	3..313	CDD:187550	185/310 (60%)
Gmer	NP_611734.1	Epimerase	4..234	CDD:279681	143/230 (62%)
gfus.1	NP_001008620.1	GDP_FS_SDR_e	6..309	CDD:187550	184/309 (60%)
gfus.1	NP_001008620.1	Epimerase	7..242	CDD:279681	151/241 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170580796
Domainoid	1	1.000	304	1.000	Domainoid score	I1350
eggNOG	1	0.900	-	-		E1_COG0451
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2484
Inparanoid	1	1.050	398	1.000	Inparanoid score	I1897
OMA	1	1.010	-	-		QHG62684
OrthoDB	1	1.010	-	-		D419698at33208
OrthoFinder	1	1.000	-	-		FOG0003311
OrthoInspector	1	1.000	-	-		otm25254
orthoMCL	1	0.900	-	-		OOG6_102554
Panther	1	1.100	-	-	LDO	PTHR43238
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3245
SonicParanoid	1	1.000	-	-		X2209
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800