DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gmer and Gfus

DIOPT Version :9

Sequence 1:	NP_611734.1	Gene:	Gmer / 37638	FlyBaseID:	FBgn0267823	Length:	321	Species:	Drosophila melanogaster
Sequence 2:	NP_001120927.1	Gene:	Gfus / 300036	RGDID:	1307028	Length:	321	Species:	Rattus norvegicus

Alignment Length:	320	Identity:	191/320 - (59%)
Similarity:	241/320 - (75%)	Gaps:	8/320 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 KVLVTGGTGLVGKALEAVIKEQSP-EDEQWFFAGSKDADLTNLAATQALFAREKPTHVIHLAAMV 66
            ::|||||:||||:|::.|:.:.:. ..|:|.|..|||||||:.|.|||||.:.:|||||||||||
  Rat     9 RILVTGGSGLVGRAIQKVVADGAGLPGEEWVFVSSKDADLTDAAQTQALFQKVQPTHVIHLAAMV 73

  Fly    67 GGLFHNMNNNLDFLRNNLLINDNVLQTAHEQGCVKVVSCLSTCIFPDKTSYPIDETMVHNGPPHP 131
            ||||.|:..||||.|.|:.||||||.:|.|.|..|||||||||||||||:|||||||:||||||.
  Rat    74 GGLFRNIKYNLDFWRKNVHINDNVLHSAFEVGTRKVVSCLSTCIFPDKTTYPIDETMIHNGPPHS 138

  Fly   132 SNYGYSYAKRLIDVQNHAYHDKYGRVYTSVIPCNIFGPHDNYNPEVSHVIPGMIYRMHQLVTEKT 196
            ||:|||||||:|||||.||..::|..:|||||.|:|||:||:|.|..||:||:|:::|.
  Rat   139 SNFGYSYAKRMIDVQNRAYFQQHGCTFTSVIPTNVFGPYDNFNIEDGHVLPGLIHKVHL------ 197

  Fly   197 DVPENDKVFTVFGSGMPLRQFVYSRDLAELMIWVLRNYESVEPIILSADEVQEVTIFEVAQAVAK 261
             ...:....||:|:|.|.|||:||.|||.|.|||||.|..|||||||..|..||:|.|.|:||.:
  Rat   198 -AKSSGSALTVWGTGKPRRQFIYSLDLARLFIWVLREYNEVEPIILSVGEEDEVSIKEAAEAVVE 261

  Fly   262 AFNFNGRLVCDTSKSDGQYKKTASNAKLRSFLPDYAFTDLETAINASVKWYIENYDQARK 321
            |.:|:|.:..|::||||||||||||.||||:|||:.||..:.|:..:..|:.|||:||||
  Rat   262 AMDFSGEVTFDSTKSDGQYKKTASNGKLRSYLPDFCFTPFKQAVKETCAWFTENYEQARK 321

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gmer	NP_611734.1	GDP_FS_SDR_e	3..313	CDD:187550	184/310 (59%)
Gmer	NP_611734.1	Epimerase	4..234	CDD:279681	141/230 (61%)
Gfus	NP_001120927.1	GDP_FS_SDR_e	9..312	CDD:187550	183/309 (59%)
Gfus	NP_001120927.1	Epimerase	10..245	CDD:279681	149/241 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166340923
Domainoid	1	1.000	295	1.000	Domainoid score	I1423
eggNOG	1	0.900	-	-		E1_COG0451
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2484
Inparanoid	1	1.050	395	1.000	Inparanoid score	I1897
OMA	1	1.010	-	-		QHG62684
OrthoDB	1	1.010	-	-		D419698at33208
OrthoFinder	1	1.000	-	-		FOG0003311
OrthoInspector	1	1.000	-	-		oto97450
orthoMCL	1	0.900	-	-		OOG6_102554
Panther	1	1.100	-	-	LDO	PTHR43238
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2209
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770