DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gmer and ger-1

DIOPT Version :9

Sequence 1:	NP_611734.1	Gene:	Gmer / 37638	FlyBaseID:	FBgn0267823	Length:	321	Species:	Drosophila melanogaster
Sequence 2:	NP_498540.1	Gene:	ger-1 / 187512	WormBaseID:	WBGene00019813	Length:	315	Species:	Caenorhabditis elegans

Alignment Length:	322	Identity:	192/322 - (59%)
Similarity:	235/322 - (72%)	Gaps:	8/322 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MKKVLVTGGTGLVGKALEAVIK-EQSPEDEQWFFAGSKDADLTNLAATQALFAREKPTHVIHLAA 64
            ||.:||||||||||.|::.|:: .:..:||:|.|.||||.||.||..|:.||...||||||||||
Worm     1 MKTILVTGGTGLVGSAIKKVVETTEKRDDEKWVFIGSKDCDLENLEETRELFESVKPTHVIHLAA 65

  Fly    65 MVGGLFHNMNNNLDFLRNNLLINDNVLQTAHEQGCVKVVSCLSTCIFPDKTSYPIDETMVHNGPP 129
            ||||||||:.:||.|.|.|:.||||||...||...:|.|||||||||||||||||||||||.|||
Worm    66 MVGGLFHNLAHNLQFFRKNMAINDNVLALCHEFDVIKCVSCLSTCIFPDKTSYPIDETMVHLGPP 130

  Fly   130 HPSNYGYSYAKRLIDVQNHAYHDKYGRVYTSVIPCNIFGPHDNYNPEVSHVIPGMIYRMHQLVTE 194
            |.||:|||||||:|||.|..|..::||.||||:|||:||||||||.:..||:|.:|::.:  |.:
Worm   131 HDSNFGYSYAKRMIDVLNKGYAQEHGRKYTSVVPCNVFGPHDNYNLQSGHVLPALIHKAY--VAQ 193

  Fly   195 KTDVPENDKVFTVFGSGMPLRQFVYSRDLAELMIWVLRNYESVEPIILSADEVQEVTIFEVAQAV 259
            :...|     ..|:|||.|||||:||.|||.|.|.|:|.||.|||||||.:|..||:|.:...||
Worm   194 RDGTP-----LQVYGSGTPLRQFIYSIDLARLFIRVVREYEDVEPIILSVNESDEVSIRDAVSAV 253

  Fly   260 AKAFNFNGRLVCDTSKSDGQYKKTASNAKLRSFLPDYAFTDLETAINASVKWYIENYDQARK 321
            .||.:|.|.:..||||:|||:||||||.||....||:.||..|.||..||:|:::||:.|||
Worm   254 VKAIDFTGDVEYDTSKADGQFKKTASNEKLLKLFPDFQFTPFEQAIQESVQWFVDNYETARK 315

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gmer	NP_611734.1	GDP_FS_SDR_e	3..313	CDD:187550	185/310 (60%)
Gmer	NP_611734.1	Epimerase	4..234	CDD:279681	141/230 (61%)
ger-1	NP_498540.1	GDP_FS_SDR_e	3..306	CDD:187550	184/309 (60%)
ger-1	NP_498540.1	Epimerase	4..235	CDD:279681	146/237 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160159403
Domainoid	1	1.000	296	1.000	Domainoid score	I797
eggNOG	1	0.900	-	-		E1_COG0451
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2484
Inparanoid	1	1.050	391	1.000	Inparanoid score	I1137
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG62684
OrthoDB	1	1.010	-	-		D419698at33208
OrthoFinder	1	1.000	-	-		FOG0003311
OrthoInspector	1	1.000	-	-		oto17560
orthoMCL	1	0.900	-	-		OOG6_102554
Panther	1	1.100	-	-	LDO	PTHR43238
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3245
SonicParanoid	1	1.000	-	-		X2209
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.800