DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment YME1L and AFG3

DIOPT Version :9

Sequence 1:	NP_001246473.1	Gene:	YME1L / 37636	FlyBaseID:	FBgn0034792	Length:	740	Species:	Drosophila melanogaster
Sequence 2:	NP_010933.1	Gene:	AFG3 / 856737	SGDID:	S000000819	Length:	761	Species:	Saccharomyces cerevisiae

Alignment Length:	529	Identity:	207/529 - (39%)
Similarity:	302/529 - (57%)	Gaps:	48/529 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   246 PKSGKTMKYLKTLQTIVVIVVFL-------GIFLSFFT--------TSNG----------SVFRS 285
            |:....:||::.......:..||       |::  |.|        .:||          :|.:|
Yeast   210 PRDRIPIKYIERSSPFTFLFPFLPTIILLGGLY--FITRKINSSPPNANGGGGGGLGGMFNVGKS 272

  Fly   286 -IQLGNQVEVDPEEINVTFEDVKGCDEAKQELKEVVEFLKSPEKFSNLGGKLPKGVLLVGPPGTG 349
             .:|.|: |.|   |.::|::|.||||||||:.|.|.|||:|.|::.||.|:|:|.:|.||||||
Yeast   273 RAKLFNK-ETD---IKISFKNVAGCDEAKQEIMEFVHFLKNPGKYTKLGAKIPRGAILSGPPGTG 333

  Fly   350 KTLLARAVAGEAKVPFFHAAGPEFDEVLVGQGARRVRDLFKAAKARAPCVIFIDEIDSVGAKRTN 414
            |||||:|.||||.|||...:|.||.|:.||.||.||||||..|::.||.:|||||||::|.:|..
Yeast   334 KTLLAKATAGEANVPFLSVSGSEFVEMFVGVGASRVRDLFTQARSMAPSIIFIDEIDAIGKERGK 398

  Fly   415 SVLHPYANQ----TINQLLSEMDGFHQNAGVIVLGATNRRDDLDQALLRPGRFDVEVMVSTPDFT 475
            ......||.    |:||||.|||||..:..|:||..|||.|.||.||:||||||..:.:.:||..
Yeast   399 GGALGGANDEREATLNQLLVEMDGFTTSDQVVVLAGTNRPDVLDNALMRPGRFDRHIQIDSPDVN 463

  Fly   476 GRKEILSLYLTKILHDEIDLD-------MLARGTSGFTGADLENMINQAALRAAIDGAETVSMKH 533
            ||::|..::|.::..|.:..|       .||..|.||||||:.|..|:|||.||......:::.|
Yeast   464 GRQQIYLVHLKRLNLDPLLTDDMNNLSGKLATLTPGFTGADIANACNEAALIAARHNDPYITIHH 528

  Fly   534 LETARDKVLMGPERKARLPDEEANTITAYHEGGHAIVAFYTKESHPLHKVTIMPRGP-SLGHTAY 597
            .|.|.::|:.|.|:|.|:..:|.....||||.|||:..::.|.:.||.||:|:|||. :||:..|
Yeast   529 FEQAIERVIAGLEKKTRVLSKEEKRSVAYHEAGHAVCGWFLKYADPLLKVSIIPRGQGALGYAQY 593

  Fly   598 IPEKERYHVTKAQLLAMMDTMMGGRAAEELVFGTDKITSGASSDLKQATSIATHMVRDWGMSDKV 662
            :| .::|.:::.|....|...:|||.:|||.|  ..:||||..|.|:.|.:|..||...|||.|:
Yeast   594 LP-PDQYLISEEQFRHRMIMALGGRVSEELHF--PSVTSGAHDDFKKVTQMANAMVTSLGMSPKI 655

  Fly   663 GLRTIEASKG-LGTGDTLGPNTIEAVDAEIKRILSDSYERAKAILRKHTREHKALAEALLKYETL 726
            |..:.:.:.| ..........|...:|.|:|.|:.|::.....:|.|:..:...:|:.||:.|.:
Yeast   656 GYLSFDQNDGNFKVNKPFSNKTARTIDLEVKSIVDDAHRACTELLTKNLDKVDLVAKELLRKEAI 720

  Fly   727 DADDIKAIL 735
            ..:|:..:|
Yeast   721 TREDMIRLL 729

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
YME1L	NP_001246473.1	FtsH_fam	254..736	CDD:273520	205/521 (39%)
AFG3	NP_010933.1	FtsH_ext	124..215	CDD:377663	1/4 (25%)
AFG3	NP_010933.1	FtsH_fam	223..730	CDD:273520	204/516 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0465
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR43655
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910