DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment YME1L and YME1

DIOPT Version :9

Sequence 1:	NP_001246473.1	Gene:	YME1L / 37636	FlyBaseID:	FBgn0034792	Length:	740	Species:	Drosophila melanogaster
Sequence 2:	NP_015349.1	Gene:	YME1 / 856135	SGDID:	S000006228	Length:	747	Species:	Saccharomyces cerevisiae

Alignment Length:	582	Identity:	259/582 - (44%)
Similarity:	355/582 - (60%)	Gaps:	43/582 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   184 MTSRLKN-ALANSPQRLDGDTPLQAEKLRR-------------LLAKSEEHGFNKAESLKIAFAE 234
            :.||.:. .:|:||:.::    |..|.|:|             ||..|.....|.:.:...:...
Yeast   137 VVSRFETPGIASSPECME----LYMEALQRIGRHSEADAVRQNLLTASSAGAVNPSLASSSSNQS 197

  Fly   235 GYLAAANSEDSPKSGKTMKYLKTL---QTIVVI-------VVFLGIFLSF-----FTTSNGSVFR 284
            ||.....|..||..|...:.|..:   .|..|:       :||..:..||     :.|.|.::.:
Yeast   198 GYHGNFPSMYSPLYGSRKEPLHVVVSESTFTVVSRWVKWLLVFGILTYSFSEGFKYITENTTLLK 262

  Fly   285 SIQLGNQVEVDPEEINVTFEDVKGCDEAKQELKEVVEFLKSPEKFSNLGGKLPKGVLLVGPPGTG 349
            |.::.:: .||..:.||.|:||.|||||:.||:|:|:|||.|.|:.:|||||||||||.||||||
Yeast   263 SSEVADK-SVDVAKTNVKFDDVCGCDEARAELEEIVDFLKDPTKYESLGGKLPKGVLLTGPPGTG 326

  Fly   350 KTLLARAVAGEAKVPFFHAAGPEFDEVLVGQGARRVRDLFKAAKARAPCVIFIDEIDSVGAKRTN 414
            |||||||.||||.|.||..:|.|||||.||.||:|:||||..|::|||.:|||||:|::|.|| |
Yeast   327 KTLLARATAGEAGVDFFFMSGSEFDEVYVGVGAKRIRDLFAQARSRAPAIIFIDELDAIGGKR-N 390

  Fly   415 SVLHPYANQTINQLLSEMDGFHQNAGVIVLGATNRRDDLDQALLRPGRFDVEVMVSTPDFTGRKE 479
            .....||.||:||||.|:|||.|.:|:|::||||..:.||:||.||||||..|.|..||..||.:
Yeast   391 PKDQAYAKQTLNQLLVELDGFSQTSGIIIIGATNFPEALDKALTRPGRFDKVVNVDLPDVRGRAD 455

  Fly   480 ILSLYLTKI-LHDEIDLDMLARGTSGFTGADLENMINQAALRAAIDGAETVSMKHLETARDKVLM 543
            ||..::.|| |.|.:|..::||||.|.:||:|.|::||||:.|....|.:|.|.|.|.|:||:||
Yeast   456 ILKHHMKKITLADNVDPTIIARGTPGLSGAELANLVNQAAVYACQKNAVSVDMSHFEWAKDKILM 520

  Fly   544 GPERKARLPDEEANTITAYHEGGHAIVAFYTKESHPLHKVTIMPRGPSLGHTAYIPEKERYHVTK 608
            |.|||..:..:.|...||:||.||||:|.||..:.||:|.||:|||.:||.|..:||.::..:||
Yeast   521 GAERKTMVLTDAARKATAFHEAGHAIMAKYTNGATPLYKATILPRGRALGITFQLPEMDKVDITK 585

  Fly   609 AQLLAMMDTMMGGRAAEELVFGTDKITSGASSDLKQATSIATHMVRDWGMSDKVGLRTIEASKGL 673
            .:..|.:|..|||:.||||::|.|..|||..|||:.||..|..||..:||||.||  .:..|:..
Yeast   586 RECQARLDVCMGGKIAEELIYGKDNTTSGCGSDLQSATGTARAMVTQYGMSDDVG--PVNLSENW 648

  Fly   674 GTGDTLGPNTI-EAVDAEIKRILSDSYERAKAILRKHTREHKALAEALLKYETLDADDIKAI 734
            .:..    |.| :..|.|:..:|.||.|||:.:|.|...|...||:.|::||||||.:|:.:
Yeast   649 ESWS----NKIRDIADNEVIELLKDSEERARRLLTKKNVELHRLAQGLIEYETLDAHEIEQV 706

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
YME1L	NP_001246473.1	FtsH_fam	254..736	CDD:273520	240/498 (48%)
YME1	NP_015349.1	HflB	227..712	CDD:223541	238/488 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157343183
Domainoid	1	1.000	163	1.000	Domainoid score	I836
eggNOG	1	0.900	-	-		E1_COG0465
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	435	1.000	Inparanoid score	I268
Isobase	1	0.950	-	0	Normalized mean entropy	S1086
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003122
OrthoInspector	1	1.000	-	-		oto99615
orthoMCL	1	0.900	-	-		OOG6_101196
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1955
SonicParanoid	1	1.000	-	-		X2093
TreeFam	1	0.960	-	-
	13	12.630