DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment YME1L and YTA12

DIOPT Version :9

Sequence 1:	NP_001246473.1	Gene:	YME1L / 37636	FlyBaseID:	FBgn0034792	Length:	740	Species:	Drosophila melanogaster
Sequence 2:	NP_013807.1	Gene:	YTA12 / 855114	SGDID:	S000004695	Length:	825	Species:	Saccharomyces cerevisiae

Alignment Length:	728	Identity:	252/728 - (34%)
Similarity:	368/728 - (50%)	Gaps:	121/728 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    84 RRLVDDVLAKVTSMLPSMRDVRVTLEE----SATQIGRVQLQNYQFEVSLTGAAGSVPTGANVKV 144
            |||.|.||.:.::.:   ::.|...||    |..:..|.:.|.| ||            |.|.:.
Yeast   105 RRLEDAVLKQESNRI---QEERKEKEEENGPSKAKSNRTKEQGY-FE------------GNNSRN 153

  Fly   145 IPTITPGLLRPLFSQQQLNQIRGFKTDRSIEAEQKRNPT----------MTSRLKNALANSPQRL 199
            ||...|    |...:..||       |.|       ||.          :|..|.:.|.:....|
Yeast   154 IPPPPP----PPPPKPPLN-------DPS-------NPVSKNVNLFQIGLTFFLLSFLLDLLNSL 200

  Fly   200 DGDTPLQAEKLR-RLLAKS-----------------EEHGFNKAESLKIAFAEGYLAAANSEDS- 245
            :..:.:..:..| :||||.                 .::|.|:|::....|   |.....|.||
Yeast   201 EEQSEITWQDFREKLLAKGYVAKLIVVNKSMVKVMLNDNGKNQADNYGRNF---YYFTIGSIDSF 262

  Fly   246 -----------------------PKSGKTMKYLKTLQTIVVIVVFLGIFLSFFTT--------SN 279
                                   .:.|...|.:  .|.:..:::..||.  :.|.        |.
Yeast   263 EHKLQKAQDELDIDKDFRIPVLYVQEGNWAKAM--FQILPTVLMIAGII--WLTRRSAQAAGGSR 323

  Fly   280 GSVF---RSIQLGNQVEVDPEEINVTFEDVKGCDEAKQELKEVVEFLKSPEKFSNLGGKLPKGVL 341
            |.:|   ||.......|.|   :.:.|:||.||||||:|:.|.|.|||.|.::..:|.|:|:|.:
Yeast   324 GGIFGLSRSKAKKFNTETD---VKIKFKDVAGCDEAKEEIMEFVSFLKEPSRYEKMGAKIPRGAI 385

  Fly   342 LVGPPGTGKTLLARAVAGEAKVPFFHAAGPEFDEVLVGQGARRVRDLFKAAKARAPCVIFIDEID 406
            |.|||||||||||:|.||||.|||:..:|.||.|:.||.||.|||||||.|:..||.::||||||
Yeast   386 LSGPPGTGKTLLAKATAGEAGVPFYFVSGSEFVEMFVGVGAARVRDLFKTARENAPSIVFIDEID 450

  Fly   407 SVGAKRTN---SVLHPYANQTINQLLSEMDGFHQNAGVIVLGATNRRDDLDQALLRPGRFDVEVM 468
            ::|..|..   |..:.....|:||:|.|||||.....|:||..|||.|.||:|||||||||..:.
Yeast   451 AIGKARQKGNFSGANDERENTLNQMLVEMDGFTPADHVVVLAGTNRPDILDKALLRPGRFDRHIN 515

  Fly   469 VSTPDFTGRKEILSLYL--TKILHDEIDL-DMLARGTSGFTGADLENMINQAALRAAIDGAETVS 530
            :..|:..|||.|.:::|  .|:..:..|| :.||..|.||:|||:.|:.|:|||.||....:.|.
Yeast   516 IDKPELEGRKAIFAVHLHHLKLAGEIFDLKNRLAALTPGFSGADIANVCNEAALIAARSDEDAVK 580

  Fly   531 MKHLETARDKVLMGPERKARLPDEEANTITAYHEGGHAIVAFYTKESHPLHKVTIMPRGP-SLGH 594
            :.|.|.|.::|:.|.|||::|...|...:.||||.|||:..:|.|.:.||.||:|:|||. :||:
Yeast   581 LNHFEQAIERVIGGVERKSKLLSPEEKKVVAYHEAGHAVCGWYLKYADPLLKVSIIPRGQGALGY 645

  Fly   595 TAYIPEKERYHVTKAQLLAMMDTMMGGRAAEELVFGTDKITSGASSDLKQATSIATHMVRDWGMS 659
            ..|:| .:.:.:|:.||...|...:|||.:|||.|  ..:|||||.|.|:.||:||.||.:.|||
Yeast   646 AQYLP-GDIFLLTEQQLKDRMTMSLGGRVSEELHF--PSVTSGASDDFKKVTSMATAMVTELGMS 707

  Fly   660 DKVGLRTIEASKGLGTGDTLGPNTIEAVDAEIKRILSDSYERAKAILRKHTREHKALAEALLKYE 724
            ||:|....:..............|.:.:|:|:.||:.:.::|...:|::...:.:.:|:.|||.|
Yeast   708 DKIGWVNYQKRDDSDLTKPFSDETGDIIDSEVYRIVQECHDRCTKLLKEKAEDVEKIAQVLLKKE 772

  Fly   725 TLDADDIKAILNE 737
            .|..:|:..:|.:
Yeast   773 VLTREDMIDLLGK 785

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
YME1L	NP_001246473.1	FtsH_fam	254..736	CDD:273520	205/499 (41%)
YTA12	NP_013807.1	FtsH_ext	<205..282	CDD:377663	13/79 (16%)
YTA12	NP_013807.1	FtsH_fam	290..784	CDD:273520	206/503 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0465
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR43655
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910