DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment YME1L and FTSH12

DIOPT Version :9

Sequence 1:	NP_001246473.1	Gene:	YME1L / 37636	FlyBaseID:	FBgn0034792	Length:	740	Species:	Drosophila melanogaster
Sequence 2:	NP_565212.1	Gene:	FTSH12 / 844294	AraportID:	AT1G79560	Length:	1008	Species:	Arabidopsis thaliana

Alignment Length:	738	Identity:	181/738 - (24%)
Similarity:	305/738 - (41%)	Gaps:	125/738 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 LSRSSASIQGMVERAARLNGILDRRLVDD--VLAKVTSMLPSMRDVRVTLEESATQIGRVQLQNY 123
            |..:..|::.::.|.||:.....::|..|  |..::...:.:.|:...|.:|        .|:..
plant   248 LETTEGSLKKIIGRNARIQTEAKKKLSQDLGVSGEIGDSVGNWRERLATWKE--------MLERE 304

  Fly   124 QFEVSLTGAAGSVPTGANVKVIPTITPGLLRPLFSQQQLNQIRGFKTDRSIEAEQKRNPTMTSRL 188
            :....|..:|.......::|.:.                ..:|.....|:.|.|..|...::.|.
plant   305 KLSEQLNSSAAKYVVEFDMKEVE----------------KSLREDVIGRTSETEGTRALWISKRW 353

  Fly   189 KNALANSP-----QRLDGD---TPLQAEKLRRLLAKSEEHGFNKAESLKIAFAEGYLAAANSEDS 245
            .......|     |:||..   ..:..|.|:||....:| ||.....:.|.. :.||    .|..
plant   354 WRYRPKLPYTYFLQKLDSSEVAAVVFTEDLKRLYVTMKE-GFPLEYIVDIPL-DPYL----FETI 412

  Fly   246 PKSGKTMKYLKTLQTIVVIVVFL----GIFLSFF---------TTSNGSVFRSI-QLGNQVEV-- 294
            ..:|..:..|:..|....:.||:    ||.:.:|         .||...:::.. ||.:....
plant   413 CNAGVEVDLLQKRQIHYFMKVFIALLPGILILWFIRESAMLLLITSKRFLYKKYNQLFDMAYAEN 477

  Fly   295 ------DPEEINVTFEDVKGCDEAKQELKEVVEFLKSPEKFSNLGGKLPKGVLLVGPPGTGKTLL 353
                  |..|....:::|....:....|.|::.::.:|.::........:||||.|||||||||.
plant   478 FILPVGDVSETKSMYKEVVLGGDVWDLLDELMIYMGNPMQYYEKDVAFVRGVLLSGPPGTGKTLF 542

  Fly   354 ARAVAGEAKVPFFHAAGPEFDEVLVGQGARRVRDLFKAAKARAPCVIFIDEIDSVGAKRTNSVLH 418
            ||.:|.|:.:||..|:|.||.: ....||.::.::|..|:..||..:|:||||::..:....  .
plant   543 ARTLAKESGLPFVFASGAEFTD-SEKSGAAKINEMFSIARRNAPAFVFVDEIDAIAGRHARK--D 604

  Fly   419 PYANQTINQLLSEMDGFHQNAG---------VIVLGATNRRDDLDQALLRPGRFDVEVMVSTPDF 474
            |....|...|::::||..:..|         ||.:.||||.|:||...:|.||.|..:.:..||.
plant   605 PRRRATFEALIAQLDGEKEKTGIDRFSLRQAVIFICATNRPDELDLEFVRSGRIDRRLYIGLPDA 669

  Fly   475 TGRKEILSLYLT-KILHDEIDLDMLARGTSGFTGADLENMINQAALRAAIDGAETVSMKHLETAR 538
            ..|.:|..::.. |.|.::||...|...|.||:|||:.|::|:||:.:...|...:..:.:....
plant   670 KQRVQIFGVHSAGKNLAEDIDFGKLVFRTVGFSGADIRNLVNEAAIMSVRKGRSYIYQQDIVDVL 734

  Fly   539 DK-------VLMGPERKARLPDE---EANTITAYHEGGHAIVA--FYTKESHPLHKVTIMPRGPS 591
            ||       ||:..|.:.:....   |...:.|.||.||.::|  |...:.|...:  ::|.|..
plant   735 DKQLLEGMGVLLTEEEQQKCEQSVSYEKKRLLAVHEAGHIVLAHLFPRFDWHAFSQ--LLPGGKE 797

  Fly   592 LGHTAYIPEK---ERYHVTKAQLLAMMDTMMGGRAAEELVFGTDKITSGASSDLKQATSIATHMV 653
            ...:.:.|.:   ::.:.|...:...|....|||.||.:||| |.:|.|...||::.|.||..||
plant   798 TAVSVFYPREDMVDQGYTTFGYMKMQMVVAHGGRCAERVVFG-DNVTDGGKDDLEKITKIAREMV 861

  Fly   654 RDWGMSDKVGLRTIEASKGLGTGD----------------------TLGPNTIEAVDAEIKRILS 696
            .. ..|.::||  .:..|.:|..|                      .:.....|....|:.|.:.
plant   862 IS-PQSARLGL--TQLVKKIGMVDLPDNPDGELIKYRWDHPHVMPAEMSVEVSELFTRELTRYIE 923

  Fly   697 DSYERAKAILR--KH-----TRE 712
            ::.|.|...||  :|     |||
plant   924 ETEELAMNALRANRHILDLITRE 946

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
YME1L	NP_001246473.1	FtsH_fam	254..736	CDD:273520	144/535 (27%)
FTSH12	NP_565212.1	FtsH_fam	429..963	CDD:273520	142/527 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0465
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR43655
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910