DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment YME1L and ftsh10

DIOPT Version :9

Sequence 1:	NP_001246473.1	Gene:	YME1L / 37636	FlyBaseID:	FBgn0034792	Length:	740	Species:	Drosophila melanogaster
Sequence 2:	NP_172231.2	Gene:	ftsh10 / 837265	AraportID:	AT1G07510	Length:	813	Species:	Arabidopsis thaliana

Alignment Length:	452	Identity:	199/452 - (44%)
Similarity:	279/452 - (61%)	Gaps:	27/452 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   301 VTFEDVKGCDEAKQELKEVVEFLKSPEKFSNLGGKLPKGVLLVGPPGTGKTLLARAVAGEAKVPF 365
            :.|:||.||:|||||:.|.|.||::|:|:.:||.|:|||.||||||||||||||:|.|||:.|||
plant   324 IYFKDVAGCEEAKQEIMEFVHFLQNPKKYEDLGAKIPKGALLVGPPGTGKTLLAKATAGESAVPF 388

  Fly   366 FHAAGPEFDEVLVGQGARRVRDLFKAAKARAPCVIFIDEIDSVGAKRTN---SVLHPYANQTINQ 427
            ...:|.:|.|:.||.|..|||:||:.|:..||.:|||||||::|..|..   |..:.....|:||
plant   389 LSISGSDFMEMFVGVGPSRVRNLFQEARQCAPSIIFIDEIDAIGRARGRGGFSGGNDERESTLNQ 453

  Fly   428 LLSEMDGFHQNAGVIVLGATNRRDDLDQALLRPGRFDVEVMVSTPDFTGRKEILSLYLTKILHDE 492
            ||.|||||...|||:||..|||.|.||:|||||||||.::.:..||..||.:|..:||.||   :
plant   454 LLVEMDGFGTTAGVVVLAGTNRPDILDKALLRPGRFDRQITIDKPDIKGRDQIFQIYLKKI---K 515

  Fly   493 IDLD------MLARGTSGFTGADLENMINQAALRAAIDGAETVSMKHLETARDKVLMGPERKARL 551
            :|.:      .||..|.||.|||:.|:.|:|||.||.....||:|.|.::|.|:|:.|.|:|.|:
plant   516 LDHEPSYYSQRLAALTPGFAGADIANVCNEAALIAARHEGATVTMAHFDSAIDRVIGGLEKKNRV 580

  Fly   552 PDEEANTITAYHEGGHAIVAFYTKESHPLHKVTIMPRG-PSLGHTAYIPEKERYHVTKAQLLAMM 615
            ..:......||||.|||:..::.:.:.||.||||:||| .:||...|:| .|...:||.||..|.
plant   581 ISKLERRTVAYHESGHAVAGWFLEHAEPLLKVTIVPRGTAALGFAQYVP-NENLLMTKEQLFDMT 644

  Fly   616 DTMMGGRAAEELVFGTDKITSGASSDLKQATSIATHMVRDWGMSDKVGL-----RTIEASKGLGT 675
            ...:||||||:::.|  :|::||.:||::.|.:....|..:|.|||:||     |..|.||....
plant   645 CMTLGGRAAEQVLIG--RISTGAQNDLEKVTKMTYAQVAVYGFSDKIGLLSFPQREDEFSKPYSN 707

  Fly   676 GDTLGPNTIEAVDAEIKRILSDSYERAKAILRKHTREHKALAEALLKYETLDADDIKAILNE 737
                  .|...:|.|::..:..:|:|...::.:|..:...:||.||:.|.|..||:..:|.|
plant   708 ------RTGAMIDEEVREWVGKAYKRTVELIEEHKEQVAQIAELLLEKEVLHQDDLTKVLGE 763

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
YME1L	NP_001246473.1	FtsH_fam	254..736	CDD:273520	197/449 (44%)
ftsh10	NP_172231.2	FtsH_ext	139..254	CDD:284011
		FtsH_fam	263..762	CDD:273520	197/449 (44%)
		P-loop_NTPase	311..>414	CDD:304359	54/89 (61%)
		AAA	364..496	CDD:278434	75/131 (57%)
		Peptidase_M41	579..760	CDD:279742	65/189 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0465
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D217929at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR43655
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.920