DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment YME1L and FTSH8

DIOPT Version :9

Sequence 1:	NP_001246473.1	Gene:	YME1L / 37636	FlyBaseID:	FBgn0034792	Length:	740	Species:	Drosophila melanogaster
Sequence 2:	NP_001321589.1	Gene:	FTSH8 / 837154	AraportID:	AT1G06430	Length:	685	Species:	Arabidopsis thaliana

Alignment Length:	565	Identity:	227/565 - (40%)
Similarity:	333/565 - (58%)	Gaps:	42/565 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   192 LANSPQRLDGDTP-LQAEKLRRLLAKSEEHGFNKAESLKIAFAEGYLAAANSEDSPKSGKTMKYL 255
            |.|..||:....| |..|.|::|.||:.:                 .||.|:::...|    ..|
plant   120 LGNRIQRVRVQLPGLSQELLQKLRAKNID-----------------FAAHNAQEDQGS----PIL 163

  Fly   256 KTLQTIVVIVVFL-GIFLSFFTTSN-----GSVFRSIQLGN---QVEVDPEEINVTFEDVKGCDE 311
            ..:..:...|:.: |:||....:|.     |.....:|:|.   :.:::| ...|||:||.|.||
plant   164 NLIGNLAFPVILIGGLFLLSRRSSGGMGGPGGPGFPLQIGQSKAKFQMEP-NTGVTFDDVAGVDE 227

  Fly   312 AKQELKEVVEFLKSPEKFSNLGGKLPKGVLLVGPPGTGKTLLARAVAGEAKVPFFHAAGPEFDEV 376
            |||:..|||||||.||:|:.:|.::||||||||||||||||||:|:||||.||||..:|.||.|:
plant   228 AKQDFMEVVEFLKKPERFTAVGARIPKGVLLVGPPGTGKTLLAKAIAGEAGVPFFSISGSEFVEM 292

  Fly   377 LVGQGARRVRDLFKAAKARAPCVIFIDEIDSVGAKRTNSV--LHPYANQTINQLLSEMDGFHQNA 439
            .||.||.|||||||.||..|||::|:||||:||.:|...:  .:....||:||||:|||||..|.
plant   293 FVGVGASRVRDLFKKAKENAPCIVFVDEIDAVGRQRGTGIGGGNDEREQTLNQLLTEMDGFEGNT 357

  Fly   440 GVIVLGATNRRDDLDQALLRPGRFDVEVMVSTPDFTGRKEILSLYL-TKILHDEIDLDMLARGTS 503
            ||||:.||||.|.||.|||||||||.:|.|..||..||.:||.::. .|.....:.|:::|..|.
plant   358 GVIVVAATNRADILDSALLRPGRFDRQVSVDVPDVKGRTDILKVHSGNKKFESGVSLEVIAMRTP 422

  Fly   504 GFTGADLENMINQAALRAAIDGAETVSMKHLETARDKVLMGPERKARLPDEEANTITAYHEGGHA 568
            ||:||||.|::|:||:.|...|...:|.|.::.:.|:::.|.|... :.|.::.::.||||.|||
plant   423 GFSGADLANLLNEAAILAGRRGKTAISSKEIDDSIDRIVAGMEGTV-MTDGKSKSLVAYHEVGHA 486

  Fly   569 IVAFYTKESHPLHKVTIMPRGPSLGHTAYIPEKERYHVTKAQLLAMMDTMMGGRAAEELVFGTDK 633
            |....|.....:.|||::|||.:.|.|.:||..:...::|.||.|.:...:|||||||::||..:
plant   487 ICGTLTPGHDAVQKVTLIPRGQARGLTWFIPSDDPTLISKQQLFARIVGGLGGRAAEEVIFGESE 551

  Fly   634 ITSGASSDLKQATSIATHMVRDWGMSDKVGLRTIEASK------GLGTGDTLGPNTIEAVDAEIK 692
            :|:||.|||:|.|.:|..||..:|||:......:::|:      .:...:::.......:|..:|
plant   552 VTTGAVSDLQQITGLAKQMVTTFGMSEIGPWSLMDSSEQSDVIMRMMARNSMSEKLANDIDTAVK 616

  Fly   693 RILSDSYERAKAILRKHTREHKALAEALLKYETLDADDIKAILNE 737
            .:...:||.|.:.:|.:......:.|.||:.||:..|:.:|||:|
plant   617 TLSDKAYEIALSQIRNNREAMDKIVEILLEKETMSGDEFRAILSE 661

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
YME1L	NP_001246473.1	FtsH_fam	254..736	CDD:273520	210/499 (42%)
FTSH8	NP_001321589.1	ftsH	77..669	CDD:214386	227/565 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0465
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D217929at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820